STRINGSTRING
BCL2L1 BCL2L1 CRKL CRKL TGFB3 TGFB3 Chuk Chuk ARAF ARAF DDB2 DDB2 NFKB1 NFKB1 ENSFDAP00000018414 ENSFDAP00000018414 BAK1 BAK1 CRK CRK MAPK3 MAPK3 Pik3r2 Pik3r2 PIK3CA PIK3CA MAPK1 MAPK1 IKBKG IKBKG HDAC1 HDAC1 ENSFDAP00000020777 ENSFDAP00000020777 SMAD4 SMAD4 SHC1 SHC1 PIK3R1 PIK3R1 TGFB1 TGFB1 Mdm2 Mdm2 CSDE1 CSDE1 CTBP1 CTBP1 CDKN1B CDKN1B SHC3 SHC3 GADD45G GADD45G AKT2 AKT2 MECOM MECOM NRAS NRAS CDK6 CDK6 KRAS KRAS TGFBR1 TGFBR1 Stat5b Stat5b PIK3CD PIK3CD HRAS HRAS BCR BCR HDAC2 HDAC2 ENSFDAP00000011804 ENSFDAP00000011804 TP53 TP53 AKT3 AKT3 Shc2 Shc2 PPP1R14B PPP1R14B E2F3 E2F3 SOS2 SOS2 Pik3r3 Pik3r3 SOS1 SOS1 RELA RELA MAP2K1 MAP2K1 BAD BAD GAB2 GAB2 SMAD3 SMAD3 GRB2 GRB2 AKT1 AKT1 CBL CBL Map2k2 Map2k2 E2F1 E2F1 Ctbp2 Ctbp2 TGFB2 TGFB2 TGFBR2 TGFBR2 RAF1 RAF1 IKBKB IKBKB CDKN1A CDKN1A ABL1 ABL1 PIK3CB PIK3CB E2F2 E2F2 CDK4 CDK4 BRAF BRAF CCND1 CCND1 BAX BAX PTPN11 PTPN11 POLK POLK RB1 RB1 ENSFDAP00000013747 ENSFDAP00000013747 NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1Bcl-2-like protein 1. (233 aa)
CRKLCrk-like protein. (303 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
DDB2DNA damage-binding protein 2. (296 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
ENSFDAP00000018414annotation not available (666 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
CRKCRK proto-oncogene, adaptor protein. (247 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
ENSFDAP00000020777annotation not available (90 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SHC1SHC-transforming protein 1. (583 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
CTBP1C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (438 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
SHC3SHC-transforming protein 3. (443 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
MECOMUncharacterized protein. (1051 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
KRASGTPase HRas. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (470 aa)
Stat5bSignal transducer and activator of transcription 5B. (736 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
BCRBreakpoint cluster region protein. (1221 aa)
HDAC2Histone deacetylase 2. (484 aa)
ENSFDAP00000011804annotation not available (202 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
Shc2SHC-transforming protein 2. (421 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
E2F3Transcription factor E2F3. (334 aa)
SOS2Son of sevenless like protein 2. (1310 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
RELATranscription factor p65. (545 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
BADBcl2 antagonist of cell death. (162 aa)
GAB2GRB2-associated-binding protein 2. (636 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CBLE3 ubiquitin-protein ligase CBL. (851 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
E2F1Transcription factor E2F1. (377 aa)
Ctbp2C-terminal-binding protein 2. (445 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
ABL1Tyrosine-protein kinase. (1012 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
E2F2Transcription factor E2F2. (391 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BAXApoptosis regulator BAX. (180 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (600 aa)
POLKDNA polymerase kappa. (862 aa)
RB1Retinoblastoma-associated protein. (882 aa)
ENSFDAP00000013747annotation not available (346 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.