STRINGSTRING
PTEN PTEN CDK6 CDK6 AKT2 AKT2 FN1 FN1 SECISBP2 SECISBP2 TRAF1 TRAF1 GADD45G GADD45G BIRC2 BIRC2 LAMA5 LAMA5 ITGA2 ITGA2 ITGB1 ITGB1 LAMC2 LAMC2 CDKN1B CDKN1B ZBTB17 ZBTB17 PIK3R1 PIK3R1 IKBKG IKBKG PIK3CA PIK3CA LAMB3 LAMB3 Pik3r2 Pik3r2 Mff Mff BAK1 BAK1 ENSFDAP00000018414 ENSFDAP00000018414 RXRG RXRG NOS2 NOS2 XIAP XIAP PTK2 PTK2 NFKB1 NFKB1 LAMB2 LAMB2 DDB2 DDB2 RARB RARB C7orf31 C7orf31 LAMC1 LAMC1 BCL2L1 BCL2L1 Chuk Chuk LOC104870857 LOC104870857 NFKBIA NFKBIA TRAF6 TRAF6 CKS1B CKS1B LOC104864952 LOC104864952 CASP9 CASP9 ENSFDAP00000013841 ENSFDAP00000013841 LAMA3 LAMA3 PIK3CD PIK3CD ITGA6 ITGA6 TP53 TP53 H920_05040 H920_05040 LOC104861153 LOC104861153 AKT3 AKT3 APAF1 APAF1 ENSFDAP00000010877 ENSFDAP00000010877 ITGA3 ITGA3 LAMA1 LAMA1 Casp3 Casp3 LOC104858517 LOC104858517 CKS2 CKS2 E2F3 E2F3 COL4A6 COL4A6 Pik3r3 Pik3r3 SKP2 SKP2 ITGAV ITGAV CCNE1 CCNE1 RXRA RXRA TRAF4 TRAF4 RXRB RXRB RELA RELA LAMC3 LAMC3 COL4A1 COL4A1 LAMA4 LAMA4 CDKN2B CDKN2B AKT1 AKT1 BIRC3 BIRC3 PTGS2 PTGS2 CDK2 CDK2 H920_14510 H920_14510 E2F1 E2F1 ENSFDAP00000002828 ENSFDAP00000002828 IKBKB IKBKB CDKN1A CDKN1A ENSFDAP00000002251 ENSFDAP00000002251 ENSFDAP00000001943 ENSFDAP00000001943 TRAF3 TRAF3 PIK3CB PIK3CB E2F2 E2F2 CDK4 CDK4 CCND1 CCND1 BAX BAX TRAF2 TRAF2 POLK POLK RB1 RB1 CCNE2 CCNE2 TRAF5 TRAF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTENPhosphatase and tensin homolog. (403 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
FN1Fibronectin. (2477 aa)
SECISBP2Selenocysteine insertion sequence-binding protein 2. (880 aa)
TRAF1TNF receptor-associated factor. (415 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
LAMA5Laminin subunit alpha-5. (3409 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (803 aa)
LAMC2Laminin subunit gamma-2. (1187 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17. (459 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LAMB3Laminin subunit beta-3. (1169 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
MffMitochondrial fission factor. (316 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
ENSFDAP00000018414annotation not available (666 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1149 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
LAMB2Laminin subunit beta-2. (1801 aa)
DDB2DNA damage-binding protein 2. (296 aa)
RARBRetinoic acid receptor beta. (448 aa)
C7orf31Uncharacterized protein. (590 aa)
LAMC1Laminin subunit gamma-1. (1576 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
LOC104870857Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (486 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC104864952Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
ENSFDAP00000013841annotation not available (257 aa)
LAMA3Laminin subunit alpha-3. (2791 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ITGA6Integrin alpha-6; Belongs to the integrin alpha chain family. (1063 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
H920_05040Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (97 aa)
LOC104861153Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
APAF1Apoptotic protease-activating factor 1. (1249 aa)
ENSFDAP00000010877annotation not available (140 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1000 aa)
LAMA1Laminin subunit alpha-1. (2977 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
LOC104858517Laminin subunit alpha-2. (1355 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (79 aa)
E2F3Transcription factor E2F3. (334 aa)
COL4A6Collagen alpha-2(IV) chain. (1685 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SKP2S-phase kinase-associated protein 2. (424 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (996 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (405 aa)
RXRARetinoid X receptor alpha. (464 aa)
TRAF4TNF receptor-associated factor. (465 aa)
RXRBRetinoic acid receptor RXR-beta. (486 aa)
RELATranscription factor p65. (545 aa)
LAMC3Laminin subunit gamma-3. (1248 aa)
COL4A1Collagen alpha-1(IV) chain. (1490 aa)
LAMA4Laminin subunit alpha-4. (1464 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (644 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (601 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
H920_14510Protein max. (163 aa)
E2F1Transcription factor E2F1. (377 aa)
ENSFDAP00000002828annotation not available (86 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
ENSFDAP00000002251annotation not available (88 aa)
ENSFDAP00000001943annotation not available (152 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
E2F2Transcription factor E2F2. (391 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BAXApoptosis regulator BAX. (180 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
POLKDNA polymerase kappa. (862 aa)
RB1Retinoblastoma-associated protein. (882 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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