STRINGSTRING
RELA RELA PPP3CB PPP3CB MAP3K3 MAP3K3 TLR4 TLR4 MAP2K6 MAP2K6 TIRAP TIRAP Pik3r3 Pik3r3 LTK LTK MYD88 MYD88 Csnk2a1 Csnk2a1 RASGRP1 RASGRP1 JUN JUN NFATC2 NFATC2 CD3G CD3G MAPK11 MAPK11 AKT3 AKT3 PPP3CA PPP3CA PTPN6 PTPN6 HRAS HRAS PIK3CD PIK3CD KRAS KRAS ZAP70 ZAP70 MAPK12 MAPK12 NRAS NRAS AKT2 AKT2 CD247 CD247 HIF1A HIF1A IFNGR2 IFNGR2 EML4 EML4 BATF BATF NFATC3 NFATC3 Pik3r2 Pik3r2 BATF2 BATF2 PIK3CA PIK3CA MAPK1 MAPK1 PLCG1 PLCG1 CSNK2B CSNK2B IKBKG IKBKG PRKCQ PRKCQ MAP2K3 MAP2K3 PIK3R1 PIK3R1 FOS FOS Ly6g5b Ly6g5b CSDE1 CSDE1 PDCD1 PDCD1 Rps6kb1 Rps6kb1 TRAF6 TRAF6 ALK ALK ENSFDAP00000016017 ENSFDAP00000016017 NFKBIA NFKBIA LOC104870857 LOC104870857 PTEN PTEN LOC104863125 LOC104863125 MTOR MTOR Chuk Chuk TRBV19 TRBV19 STAT3 STAT3 TRBV6-4 TRBV6-4 ENSFDAP00000017754 ENSFDAP00000017754 NFKB1 NFKB1 JAK2 JAK2 PPP3R1 PPP3R1 JAK1 JAK1 ENSFDAP00000018414 ENSFDAP00000018414 TRAV22 TRAV22 MAPK3 MAPK3 NFKBIB NFKBIB LOC104855315 LOC104855315 EGF EGF PTPN11 PTPN11 IFNG IFNG RPS6KB2 RPS6KB2 STAT1 STAT1 NFKBIE NFKBIE PIK3CB PIK3CB PPP3CC PPP3CC CD274 CD274 CD28 CD28 MAPK13 MAPK13 IKBKB IKBKB RAF1 RAF1 CD3D CD3D ENSFDAP00000002977 ENSFDAP00000002977 Map2k2 Map2k2 TLR2 TLR2 CD3E CD3E EGFR EGFR AKT1 AKT1 BATF3 BATF3 MAPK14 MAPK14 LCK LCK CSNK2A2 CSNK2A2 MAP2K1 MAP2K1 NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELATranscription factor p65. (545 aa)
PPP3CBSerine/threonine-protein phosphatase. (499 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (616 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (209 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LTKLeukocyte tyrosine kinase receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. (766 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Csnk2a1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
RASGRP1RAS guanyl-releasing protein 1. (796 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (850 aa)
CD3GCD3g molecule. (182 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
KRASGTPase HRas. (189 aa)
ZAP70Tyrosine-protein kinase. (576 aa)
MAPK12Mitogen-activated protein kinase 12. (316 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (164 aa)
HIF1AHypoxia-inducible factor 1-alpha. (815 aa)
IFNGR2Interferon gamma receptor 2. (319 aa)
EML4Echinoderm microtubule-associated protein-like 4. (997 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1043 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
BATF2BZIP domain-containing protein. (257 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (183 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
FOSProto-oncogene c-Fos. (380 aa)
Ly6g5bUncharacterized protein. (193 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
PDCD1Programmed cell death protein 1. (284 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
ALKALK receptor tyrosine kinase. (1068 aa)
ENSFDAP00000016017annotation not available (223 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
LOC104870857Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (486 aa)
PTENPhosphatase and tensin homolog. (403 aa)
LOC104863125Toll-like receptor 9. (1029 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
STAT3Signal transducer and activator of transcription. (758 aa)
TRBV6-4T cell receptor beta variable 6-4. (101 aa)
ENSFDAP00000017754annotation not available (143 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PPP3R1Calcineurin subunit B type 1. (164 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
ENSFDAP00000018414annotation not available (666 aa)
TRAV22T cell receptor alpha variable 22. (123 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
NFKBIBNF-kappa-B inhibitor beta. (358 aa)
LOC104855315TIR domain-containing adapter molecule 2; Belongs to the EMP24/GP25L family. (235 aa)
EGFPro-epidermal growth factor. (1155 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (600 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
NFKBIENF-kappa-B inhibitor epsilon. (305 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPP3CCSerine/threonine-protein phosphatase. (493 aa)
CD274Programmed cell death 1 ligand 1. (322 aa)
CD28T-cell-specific surface glycoprotein CD28. (255 aa)
MAPK13Mitogen-activated protein kinase 13. (323 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (166 aa)
ENSFDAP00000002977annotation not available (131 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
TLR2Toll-like receptor 2. (718 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (169 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (96 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
LCKTyrosine-protein kinase. (506 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (315 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (783 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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