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gcvH gcvH purL purL AFG36198.1 AFG36198.1 AFG36410.1 AFG36410.1 AFG36414.1 AFG36414.1 AFG36415.1 AFG36415.1 AFG36422.1 AFG36422.1 fhs fhs purC purC purK purK purE purE AFG36584.1 AFG36584.1 AFG36639.1 AFG36639.1 AFG36642.1 AFG36642.1 AFG37031.1 AFG37031.1 AFG37032.1 AFG37032.1 AFG37175.1 AFG37175.1 AFG37278.1 AFG37278.1 AFG37400.1 AFG37400.1 pyrD pyrD AFG37418.1 AFG37418.1 guaA guaA purA purA guaB guaB AFG37669.1 AFG37669.1 AFG37674.1 AFG37674.1 AFG37675.1 AFG37675.1 folD folD AFG37905.1 AFG37905.1 AFG37943.1 AFG37943.1 AFG37944.1 AFG37944.1 carB carB carA carA apt apt AFG37968.1 AFG37968.1 surE surE purF purF purM purM purN purN purD purD AFG38053.1 AFG38053.1 AFG38054.1 AFG38054.1 adk adk AFG38196.1 AFG38196.1 guaC guaC AFG38332.1 AFG38332.1 glyA glyA pyrE pyrE pyrC pyrC thyX thyX AFG38848.1 AFG38848.1 AFG38849.1 AFG38849.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
purLPhosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...] (1017 aa)
AFG36198.1Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain protein; TIGRFAM: phosphoribosylformylglycinamidine synthase I. (262 aa)
AFG36410.15,10-methenyltetrahydrofolate synthetase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (197 aa)
AFG36414.1Glutamine synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] (1275 aa)
AFG36415.1PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (467 aa)
AFG36422.1Aminoacyl-histidine dipeptidase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: Xaa-His dipeptidase. (500 aa)
fhsFormyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (583 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (320 aa)
purKPhosphoribosylaminoimidazole carboxylase (NCAIR synthetase); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (446 aa)
purEPhosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa)
AFG36584.1Glycine dehydrogenase, decarboxylating; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; Glycine cleavage system P-protein; TIGRFAM: glycine dehydrogenase (decarboxylating); glycine cleavage system T protein; Belongs to the GcvT family. (1340 aa)
AFG36639.1Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (324 aa)
AFG36642.1Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (336 aa)
AFG37031.1Gamma-glutamyltransferase; PFAM: Gamma-glutamyltranspeptidase. (683 aa)
AFG37032.1Gamma-glutamyltransferase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase. (821 aa)
AFG37175.1Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (227 aa)
AFG37278.1PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (452 aa)
AFG37400.1PFAM: Permease family; TIGRFAM: uracil-xanthine permease. (445 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (308 aa)
AFG37418.12-polyprenylphenol hydroxylase-like oxidoreductase; PFAM: Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain. (278 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (520 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (411 aa)
guaBInosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (480 aa)
AFG37669.1PFAM: Lyase. (477 aa)
AFG37674.1AICAR transformylase/IMP cyclohydrolase PurH; PFAM: AICARFT/IMPCHase bienzyme. (413 aa)
AFG37675.1AICAR transformylase/IMP cyclohydrolase PurH; PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain. (230 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
AFG37905.1Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1072 aa)
AFG37943.1PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. (487 aa)
AFG37944.1PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1540 aa)
carBCarbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1074 aa)
carAPFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (389 aa)
aptPRPP-binding protein, adenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
AFG37968.1PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Aspartate carbamoyltransferase regulatory chain, metal binding domain; Aspartate carbamoyltransferase regulatory chain, allosteric domain; TIGRFAM: aspartate carbamoyltransferase. (526 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (254 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa)
purMPhosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase. (315 aa)
purNFolate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (194 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (416 aa)
AFG38053.1PFAM: Ammonium Transporter Family; TIGRFAM: ammonium transporter. (448 aa)
AFG38054.1PFAM: Nitrogen regulatory protein P-II. (113 aa)
adkAdenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (210 aa)
AFG38196.1PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
guaCIMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (367 aa)
AFG38332.1GMP synthase family protein; PFAM: Glutamine amidotransferase class-I. (235 aa)
glyAGlycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
pyrEOrotidine 5''-phosphate decarboxylase, subfamily 2; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP); Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. (492 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (341 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (286 aa)
AFG38848.12-polyprenylphenol hydroxylase-like oxidoreductase; PFAM: Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain. (276 aa)
AFG38849.1NADPH-dependent glutamate synthase, homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (509 aa)
Your Current Organism:
Spirochaeta africana
NCBI taxonomy Id: 889378
Other names: S. africana DSM 8902, Spirochaeta africana DSM 8902, Spirochaeta africana Z-7692, Spirochaeta africana str. DSM 8902, Spirochaeta africana strain DSM 8902
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