STRINGSTRING
gcvH gcvH gpsA gpsA AFG36584.1 AFG36584.1 AFG36641.1 AFG36641.1 AFG36702.1 AFG36702.1 AFG37197.1 AFG37197.1 AFG37579.1 AFG37579.1 guaB guaB AFG37807.1 AFG37807.1 AFG37809.1 AFG37809.1 AFG37858.1 AFG37858.1 AFG37943.1 AFG37943.1 guaC guaC AFG38359.1 AFG38359.1 AFG38360.1 AFG38360.1 AFG38436.1 AFG38436.1 AFG38439.1 AFG38439.1 AFG38440.1 AFG38440.1 AFG38718.1 AFG38718.1 AFG38746.1 AFG38746.1 AFG38849.1 AFG38849.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (353 aa)
AFG36584.1Glycine dehydrogenase, decarboxylating; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; Glycine cleavage system P-protein; TIGRFAM: glycine dehydrogenase (decarboxylating); glycine cleavage system T protein; Belongs to the GcvT family. (1340 aa)
AFG36641.1Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: Domain of unknown function; domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. (1066 aa)
AFG36702.1TM2 domain-containing protein; PFAM: TM2 domain. (178 aa)
AFG37197.1Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains. (495 aa)
AFG37579.1PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (195 aa)
guaBInosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (480 aa)
AFG37807.1Hydrogenase, Fe-only; PFAM: Iron only hydrogenase large subunit, C-terminal domain; 2Fe-2S iron-sulfur cluster binding domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Iron hydrogenase small subunit; TIGRFAM: [FeFe] hydrogenase, group A. (594 aa)
AFG37809.1PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit. (193 aa)
AFG37858.1PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form. (459 aa)
AFG37943.1PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. (487 aa)
guaCIMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (367 aa)
AFG38359.1Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains. (523 aa)
AFG38360.1Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains. (534 aa)
AFG38436.1PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit. (164 aa)
AFG38439.1NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4Fe-4S binding domain; Respiratory-chain NADH dehydrogenase 24 Kd subunit; Respiratory-chain NADH dehydrogenase 51 Kd subunit; SLBB domain. (598 aa)
AFG38440.1Hydrogenase, Fe-only; PFAM: Iron only hydrogenase large subunit, C-terminal domain; 2Fe-2S iron-sulfur cluster binding domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Iron hydrogenase small subunit; TIGRFAM: [FeFe] hydrogenase, group A. (582 aa)
AFG38718.1Alkyl hydroperoxide reductase, F subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: alkyl hydroperoxide reductase, F subunit. (565 aa)
AFG38746.1Lactate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (320 aa)
AFG38849.1NADPH-dependent glutamate synthase, homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase (NADPH), homotetrameric. (509 aa)
Your Current Organism:
Spirochaeta africana
NCBI taxonomy Id: 889378
Other names: S. africana DSM 8902, Spirochaeta africana DSM 8902, Spirochaeta africana Z-7692, Spirochaeta africana str. DSM 8902, Spirochaeta africana strain DSM 8902
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