STRINGSTRING
INSIG2 INSIG2 HMGCS2 HMGCS2 HSD17B7 HSD17B7 PRKAA2 PRKAA2 DHCR24 DHCR24 NSDHL NSDHL MVK MVK LBR LBR INSIG1 INSIG1 A306_00002566 A306_00002566 A306_00002460 A306_00002460 CFTR CFTR HMGCR HMGCR LSS LSS FDFT1 FDFT1 PRKAA1 PRKAA1 SC5D SC5D HMGCS1 HMGCS1 APOA1 APOA1 FDPS FDPS MVD MVD DHCR7 DHCR7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (403 aa)
HSD17B7Hydroxysteroid (17-beta) dehydrogenase 7. (306 aa)
PRKAA2Non-specific serine/threonine protein kinase. (480 aa)
DHCR2424-dehydrocholesterol reductase. (427 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (346 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
LBRLamin B receptor. (608 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (265 aa)
A306_00002566Lanosterol 14-alpha demethylase. (274 aa)
A306_00002460Isopentenyl-diphosphate Delta-isomerase 1. (227 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (634 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (390 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (289 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (522 aa)
APOA1Apolipoprotein A-I. (264 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (304 aa)
MVDDiphosphomevalonate decarboxylase. (356 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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