69 items (Columba livia) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	ENPP4	Ectonucleotide pyrophosphatase/phosphodiesterase 4 (Putative), transcript variant X2. (452 aa)
	A306_00000316	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (534 aa)
	PEAR1	Platelet endothelial aggregation receptor 1. (288 aa)
	ENTPD2	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (418 aa)
	A306_00015335	Proteinase-activated receptor 3; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	SERPING1	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. (342 aa)
	A306_00014605	Platelet glycoprotein Ib alpha chain-like, transcript variant X1. (740 aa)
	HPS6	Hermansky-Pudlak syndrome 6. (774 aa)
	F2RL3	Coagulation factor II (Thrombin) receptor-like 3; Belongs to the G-protein coupled receptor 1 family. (438 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (620 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (781 aa)
	PROC	Protein C (Inactivator of coagulation factors Va and VIIIa), transcript variant X1. (433 aa)
	A306_00010588	Venom prothrombin activator porpharin-D-like. (618 aa)
	GP9	Glycoprotein IX (Platelet), transcript variant X1. (194 aa)
	PROCR	Protein C receptor, endothelial. (223 aa)
	SRF	Serum response factor isoform X2. (404 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	FGA	Fibrinogen alpha chain. (766 aa)
	FGB	Fibrinogen beta chain. (480 aa)
	FGG	Fibrinogen gamma chain. (436 aa)
	F2RL2	Coagulation factor II (Thrombin) receptor-like 2. (381 aa)
	P2RY12	Purinergic receptor P2Y, G-protein coupled, 12. (376 aa)
	P2RX1	Purinergic receptor P2X, ligand gated ion channel, 1. (315 aa)
	F9	Coagulation factor IX. (463 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (276 aa)
	GNA13	Guanine nucleotide binding protein (G protein), alpha 13. (371 aa)
	APOH	Apolipoprotein H (Beta-2-glycoprotein I). (348 aa)
	GP1BB	Glycoprotein Ib (Platelet), beta polypeptide. (204 aa)
	SERPIND1	Serpin peptidase inhibitor, clade D (Heparin cofactor), member 1; Belongs to the serpin family. (304 aa)
	MMRN1	Multimerin 1. (1189 aa)
	THBD	Thrombomodulin. (204 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (926 aa)
	F8	Coagulation factor VIII, procoagulant component, transcript variant X1; Belongs to the multicopper oxidase family. (2231 aa)
	A306_00000007	Uncharacterized protein. (289 aa)
	SERPINE2	Glia-derived nexin isoform X2; Belongs to the serpin family. (436 aa)
	MPL	MPL proto-oncogene, thrombopoietin receptor. (542 aa)
	BLOC1S6	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (179 aa)
	A306_00005714	Coagulation factor XIII B chain. (1158 aa)
	F3	Coagulation factor III (Thromboplastin, tissue factor). (272 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	SERPINC1	Serpin peptidase inhibitor, clade C (Antithrombin), member 1; Belongs to the serpin family. (502 aa)
	HABP2	Hyaluronan binding protein 2, transcript variant X1. (562 aa)
	ADRA2A	Adrenoceptor alpha 2A. (444 aa)
	SLC7A11	Solute carrier family 7 (Anionic amino acid transporter light chain, xc-system), member 11. (503 aa)
	TSPAN32	Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (259 aa)
	HPS5	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1135 aa)
	TFPI	Tissue factor pathway inhibitor isoform X1. (338 aa)
	ANO6	Anoctamin. (603 aa)
	A306_00004513	Cystine/glutamate transporter, transcript variant X1. (474 aa)
	PROS1	Protein S (Alpha). (619 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	P2RY8	Purinergic receptor P2Y, G-protein coupled, 8; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	ADRA2C	Adrenoceptor alpha 2C. (444 aa)
	HGFAC	HGF activator. (587 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (609 aa)
	TYRO3	TYRO3 protein tyrosine kinase. (842 aa)
	SERPINA10	Protein Z-dependent protease inhibitor isoform X1; Belongs to the serpin family. (461 aa)
	TFPI2	Tissue factor pathway inhibitor 2. (207 aa)
	F10	Coagulation factor X; Belongs to the peptidase S1 family. (462 aa)
	F7	Coagulation factor VII (Serum prothrombin conversion accelerator). (425 aa)
	PROZ	Protein Z, vitamin K-dependent plasma glycoprotein; Belongs to the peptidase S1 family. (363 aa)
	F5	Coagulation factor V (Proaccelerin, labile factor); Belongs to the multicopper oxidase family. (1931 aa)
	GAS6	Growth arrest-specific 6. (677 aa)
	CPB2	Carboxypeptidase B2 (Plasma). (422 aa)
	A306_00000619	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (802 aa)
	A306_00000618	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (817 aa)
	DTNBP1	Dystrobrevin binding protein 1. (330 aa)
	BLOC1S4	Biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino. (115 aa)
	PLEK	Pleckstrin, transcript variant X1. (353 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000007	A306_00000618	A0A2I0MBK5	A0A2I0MV53	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.916
A306_00000007	A306_00000619	A0A2I0MBK5	A0A2I0MV52	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.916
A306_00000007	A306_00005714	A0A2I0MBK5	A0A2I0MDQ0	Uncharacterized protein.	Coagulation factor XIII B chain.	0.718
A306_00000007	APOH	A0A2I0MBK5	A0A2I0M741	Uncharacterized protein.	Apolipoprotein H (Beta-2-glycoprotein I).	0.648
A306_00000007	CPB2	A0A2I0MBK5	A0A2I0MSW2	Uncharacterized protein.	Carboxypeptidase B2 (Plasma).	0.484
A306_00000007	F2	A0A2I0MBK5	A0A2I0MNE5	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.609
A306_00000007	FGA	A0A2I0MBK5	A0A2I0LXU7	Uncharacterized protein.	Fibrinogen alpha chain.	0.694
A306_00000007	FGB	A0A2I0MBK5	A0A2I0LXU9	Uncharacterized protein.	Fibrinogen beta chain.	0.548
A306_00000007	FGG	A0A2I0MBK5	A0A2I0LXV0	Uncharacterized protein.	Fibrinogen gamma chain.	0.605
A306_00000007	HABP2	A0A2I0MBK5	A0A2I0MEU6	Uncharacterized protein.	Hyaluronan binding protein 2, transcript variant X1.	0.457
A306_00000007	HGFAC	A0A2I0MBK5	A0A2I0MN06	Uncharacterized protein.	HGF activator.	0.556
A306_00000007	PROC	A0A2I0MBK5	A0A2I0LTQ6	Uncharacterized protein.	Protein C (Inactivator of coagulation factors Va and VIIIa), transcript variant X1.	0.543
A306_00000007	SERPINC1	A0A2I0MBK5	A0A2I0MED6	Uncharacterized protein.	Serpin peptidase inhibitor, clade C (Antithrombin), member 1; Belongs to the serpin family.	0.599
A306_00000007	SERPIND1	A0A2I0MBK5	A0A2I0M850	Uncharacterized protein.	Serpin peptidase inhibitor, clade D (Heparin cofactor), member 1; Belongs to the serpin family.	0.555
A306_00000618	A306_00000007	A0A2I0MV53	A0A2I0MBK5	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Uncharacterized protein.	0.916
A306_00000618	A306_00000619	A0A2I0MV53	A0A2I0MV52	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.901
A306_00000618	A306_00005714	A0A2I0MV53	A0A2I0MDQ0	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Coagulation factor XIII B chain.	0.427
A306_00000618	APOH	A0A2I0MV53	A0A2I0M741	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Apolipoprotein H (Beta-2-glycoprotein I).	0.632
A306_00000618	CPB2	A0A2I0MV53	A0A2I0MSW2	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Carboxypeptidase B2 (Plasma).	0.545
A306_00000618	F2	A0A2I0MV53	A0A2I0MNE5	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.728