STRINGSTRING
CDCP2 CDCP2 A306_00000295 A306_00000295 GBA2 GBA2 MVD MVD STAR STAR A306_00011604 A306_00011604 FDPS FDPS A306_00011602 A306_00011602 A306_00011603 A306_00011603 HDLBP HDLBP A306_00000138 A306_00000138 A306_00013140 A306_00013140 CETP CETP LCAT LCAT LDLRAP1 LDLRAP1 APOA1 APOA1 ERLIN2 ERLIN2 HMGCS1 HMGCS1 SC5D SC5D NFE2L1 NFE2L1 SREBF1 SREBF1 PRKAA1 PRKAA1 FDFT1 FDFT1 ERLIN1 ERLIN1 VLDLR VLDLR LSS LSS CH25H CH25H MBTPS1 MBTPS1 TMEM130 TMEM130 HMGCR HMGCR PTCHD2 PTCHD2 LBR LBR LIPC LIPC A306_00006782 A306_00006782 SCARB1 SCARB1 MVK MVK NSDHL NSDHL ANGPTL3 ANGPTL3 DHCR24 DHCR24 LEPR LEPR PRKAA2 PRKAA2 PCSK9 PCSK9 FDX1 FDX1 CLN6 CLN6 HSD17B7 HSD17B7 HMGCS2 HMGCS2 A306_00006559 A306_00006559 INSIG2 INSIG2 DHCR7 DHCR7 CAT CAT LRP5 LRP5 XIRP2 XIRP2 CFTR CFTR SREBF2 SREBF2 MBTPS2 MBTPS2 NPC2 NPC2 A306_00002247 A306_00002247 A306_00002460 A306_00002460 A306_00002566 A306_00002566 CUBN CUBN INSIG1 INSIG1 APP APP CLN8 CLN8 ARV1 ARV1 APOB APOB A306_00001123 A306_00001123 A306_00001464 A306_00001464 A306_00001477 A306_00001477 NPC1 NPC1 SQLE SQLE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDCP2CUB domain containing protein 2. (538 aa)
A306_00000295SSD domain-containing protein. (741 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (820 aa)
MVDDiphosphomevalonate decarboxylase. (356 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (262 aa)
A306_00011604Glucosylceramidase. (500 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (304 aa)
A306_00011602Glucosylceramidase. (524 aa)
A306_00011603Glucosylceramidase. (407 aa)
HDLBPHigh density lipoprotein binding protein. (1265 aa)
A306_00000138Uncharacterized protein. (1075 aa)
A306_00013140LIM domain and actin-binding protein 1. (624 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (499 aa)
LCATLecithin-cholesterol acyltransferase. (454 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (260 aa)
APOA1Apolipoprotein A-I. (264 aa)
ERLIN2ER lipid raft associated 2. (416 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (522 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (289 aa)
NFE2L1Nuclear factor, erythroid 2-like 1. (471 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1025 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (390 aa)
ERLIN1ER lipid raft associated 1. (294 aa)
VLDLRVery low density lipoprotein receptor. (575 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (634 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (274 aa)
MBTPS1Membrane-bound transcription factor peptidase, site 1. (1061 aa)
TMEM130Transmembrane protein 130. (410 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
PTCHD2Patched domain containing 2. (1329 aa)
LBRLamin B receptor. (608 aa)
LIPCLipase, hepatic. (496 aa)
A306_00006782Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (503 aa)
SCARB1Scavenger receptor class B, member 1; Belongs to the CD36 family. (457 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (346 aa)
ANGPTL3Angiopoietin-like 3. (471 aa)
DHCR2424-dehydrocholesterol reductase. (427 aa)
LEPRLeptin receptor. (889 aa)
PRKAA2Non-specific serine/threonine protein kinase. (480 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (545 aa)
FDX1Ferredoxin 1. (125 aa)
CLN6Ceroid-lipofuscinosis, neuronal 6, late infantile, variant. (324 aa)
HSD17B7Hydroxysteroid (17-beta) dehydrogenase 7. (306 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (403 aa)
A306_00006559Deleted in malignant brain tumors 1 protein. (1081 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
LRP5Low density lipoprotein receptor-related protein 5, transcript variant X2. (1591 aa)
XIRP2Xin actin binding repeat containing 2. (606 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (448 aa)
MBTPS2Membrane-bound transcription factor peptidase, site 2. (481 aa)
NPC2Niemann-Pick disease, type C2. (146 aa)
A306_00002247Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (513 aa)
A306_00002460Isopentenyl-diphosphate Delta-isomerase 1. (227 aa)
A306_00002566Lanosterol 14-alpha demethylase. (274 aa)
CUBNCubilin (Intrinsic factor-cobalamin receptor). (3121 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (265 aa)
APPAmyloid beta (A4) protein. (716 aa)
CLN8Ceroid-lipofuscinosis, neuronal 8. (285 aa)
ARV1ARV1 homolog, fatty acid homeostatsis modulator. (199 aa)
APOBApolipoprotein B. (2608 aa)
A306_0000112324-hydroxycholesterol 7-alpha-hydroxylase, transcript variant X1; Belongs to the cytochrome P450 family. (466 aa)
A306_0000146425-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (493 aa)
A306_00001477Cholesterol 7-alpha-monooxygenase. (514 aa)
NPC1Niemann-Pick disease, type C1. (1266 aa)
SQLESqualene epoxidase. (572 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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