STRINGSTRING
R3HDM4 R3HDM4 FDPS FDPS APOA1 APOA1 HMGCS1 HMGCS1 SC5D SC5D PRKAA1 PRKAA1 FDFT1 FDFT1 MSMO1 MSMO1 LSS LSS CH25H CH25H HMGCR HMGCR LBR LBR MVK MVK NSDHL NSDHL DHCR24 DHCR24 PRKAA2 PRKAA2 HSD17B7 HSD17B7 HMGCS2 HMGCS2 INSIG2 INSIG2 A306_00004710 A306_00004710 DHCR7 DHCR7 MVD MVD CFTR CFTR A306_00004355 A306_00004355 CUNH14orf1 CUNH14orf1 A306_00002460 A306_00002460 A306_00002566 A306_00002566 INSIG1 INSIG1 SQLE SQLE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
R3HDM4R3H domain containing 4. (234 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (304 aa)
APOA1Apolipoprotein A-I. (264 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (522 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (289 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (390 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (297 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (634 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (274 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
LBRLamin B receptor. (608 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (346 aa)
DHCR2424-dehydrocholesterol reductase. (427 aa)
PRKAA2Non-specific serine/threonine protein kinase. (480 aa)
HSD17B7Hydroxysteroid (17-beta) dehydrogenase 7. (306 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (403 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
A306_00004710NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (293 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
MVDDiphosphomevalonate decarboxylase. (356 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
A306_00004355NADH-cytochrome b5 reductase 3. (402 aa)
CUNH14orf1Uncharacterized protein. (104 aa)
A306_00002460Isopentenyl-diphosphate Delta-isomerase 1. (227 aa)
A306_00002566Lanosterol 14-alpha demethylase. (274 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (265 aa)
SQLESqualene epoxidase. (572 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.