(63 nodes) Cortical cytoskeleton network (Columba livia)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP1R9A	Protein phosphatase 1, regulatory subunit 9A, transcript variant X1. (1345 aa)
	A306_00000182	Uncharacterized protein. (826 aa)
	A306_00000398	Calponin-homology (CH) domain-containing protein. (115 aa)
	A306_00000178	Uncharacterized protein. (433 aa)
	A306_00000216	HP domain-containing protein. (448 aa)
	A306_00015009	Spectrin beta chain, non-erythrocytic 4. (933 aa)
	MTSS1L	Metastasis suppressor 1-like. (827 aa)
	A306_00000103	Uncharacterized protein. (409 aa)
	A306_00014837	Alpha-actinin-4-like. (847 aa)
	MYO1A	Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (299 aa)
	DBNL	Drebrin-like. (537 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (2021 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (975 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
	SLC2A1	Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (484 aa)
	CDH15	Cadherin-15. (530 aa)
	NF2	Neurofibromin 2 (Merlin). (592 aa)
	A306_00014192	Hematopoietic lineage cell-specific protein. (331 aa)
	MAPRE1	Microtubule-associated protein, RP/EB family, member 1. (263 aa)
	MYADM	Myeloid-associated differentiation marker. (299 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (310 aa)
	SHROOM3	Shroom family member 3. (1810 aa)
	CAPZA3	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (291 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (532 aa)
	SHROOM1	Shroom family member 1. (1267 aa)
	LLGL1	Uncharacterized protein. (779 aa)
	MYRIP	Myosin VIIA and Rab interacting protein. (875 aa)
	CDK5RAP2	CDK5 regulatory subunit associated protein 2. (1905 aa)
	CALD1	Caldesmon 1, transcript variant X1. (769 aa)
	NOS2	Nitric oxide synthase 2, inducible. (944 aa)
	ANLN	Anillin actin binding protein. (1096 aa)
	COTL1	Coactosin-like F-actin binding protein 1. (142 aa)
	A306_00008521	Merlin. (647 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
	SPTAN1	Spectrin, alpha, non-erythrocytic 1, transcript variant X1. (2533 aa)
	CIB2	Calcium and integrin binding family member 2, transcript variant X1. (229 aa)
	LLGL2	WD_REPEATS_REGION domain-containing protein. (1026 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (273 aa)
	SPTBN1	Spectrin, beta, non-erythrocytic 1. (936 aa)
	ACTR2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (381 aa)
	ERC2	ELKS/RAB6-interacting/CAST family member 2. (342 aa)
	A306_00009072	ERC protein 2. (433 aa)
	PLEKHH2	Pleckstrin homology domain containing, family H (With MyTH4 domain) member 2. (1499 aa)
	MPP1	Membrane protein, palmitoylated 1, 55kDa; Belongs to the MAGUK family. (425 aa)
	VCL	Vinculin. (1119 aa)
	CLASP1	Cytoplasmic linker associated protein 1, transcript variant X1. (1496 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (3482 aa)
	A306_00003949	Neurabin-1-like. (537 aa)
	MLPH	Melanophilin. (276 aa)
	A306_00003948	Neurabin-1-like. (250 aa)
	MYO1B	Myosin IB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1119 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1, transcript variant X4. (1117 aa)
	MAEA	Macrophage erythroblast attacher, transcript variant X1. (386 aa)
	WDR1	WD repeat domain 1. (620 aa)
	ACTN1	Actinin, alpha 1, transcript variant X6. (864 aa)
	SPTBN5	Spectrin, beta, non-erythrocytic 5. (3874 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1413 aa)
	CDH2	Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (878 aa)
	BASP1	Brain abundant, membrane attached signal protein 1. (244 aa)
	COBL	Cordon-bleu WH2 repeat protein, transcript variant X1. (1363 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1116 aa)
	DFNB59	Deafness, autosomal recessive 59. (357 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000103	A306_00000182	A0A2I0LIG4	A0A2I0LGR9	Uncharacterized protein.	Uncharacterized protein.	0.915
A306_00000103	A306_00000398	A0A2I0LIG4	A0A2I0LH03	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.900
A306_00000103	A306_00014837	A0A2I0LIG4	A0A2I0LIT4	Uncharacterized protein.	Alpha-actinin-4-like.	0.904
A306_00000103	A306_00015009	A0A2I0LIG4	A0A2I0LHF9	Uncharacterized protein.	Spectrin beta chain, non-erythrocytic 4.	0.908
A306_00000103	ACTN1	A0A2I0LIG4	A0A2I0MNV2	Uncharacterized protein.	Actinin, alpha 1, transcript variant X6.	0.903
A306_00000103	SPTAN1	A0A2I0LIG4	A0A2I0M3V0	Uncharacterized protein.	Spectrin, alpha, non-erythrocytic 1, transcript variant X1.	0.844
A306_00000178	A306_00014837	A0A2I0LH55	A0A2I0LIT4	Uncharacterized protein.	Alpha-actinin-4-like.	0.446
A306_00000178	ACTN1	A0A2I0LH55	A0A2I0MNV2	Uncharacterized protein.	Actinin, alpha 1, transcript variant X6.	0.446
A306_00000178	DBNL	A0A2I0LH55	A0A2I0LJM2	Uncharacterized protein.	Drebrin-like.	0.421
A306_00000178	VCL	A0A2I0LH55	A0A2I0MFM6	Uncharacterized protein.	Vinculin.	0.488
A306_00000182	A306_00000103	A0A2I0LGR9	A0A2I0LIG4	Uncharacterized protein.	Uncharacterized protein.	0.915
A306_00000182	A306_00000398	A0A2I0LGR9	A0A2I0LH03	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.814
A306_00000182	SPTAN1	A0A2I0LGR9	A0A2I0M3V0	Uncharacterized protein.	Spectrin, alpha, non-erythrocytic 1, transcript variant X1.	0.844
A306_00000398	A306_00000103	A0A2I0LH03	A0A2I0LIG4	Calponin-homology (CH) domain-containing protein.	Uncharacterized protein.	0.900
A306_00000398	A306_00000182	A0A2I0LH03	A0A2I0LGR9	Calponin-homology (CH) domain-containing protein.	Uncharacterized protein.	0.814
A306_00000398	A306_00014837	A0A2I0LH03	A0A2I0LIT4	Calponin-homology (CH) domain-containing protein.	Alpha-actinin-4-like.	0.857
A306_00000398	A306_00015009	A0A2I0LH03	A0A2I0LHF9	Calponin-homology (CH) domain-containing protein.	Spectrin beta chain, non-erythrocytic 4.	0.900
A306_00000398	ACTN1	A0A2I0LH03	A0A2I0MNV2	Calponin-homology (CH) domain-containing protein.	Actinin, alpha 1, transcript variant X6.	0.572
A306_00000398	SPTAN1	A0A2I0LH03	A0A2I0M3V0	Calponin-homology (CH) domain-containing protein.	Spectrin, alpha, non-erythrocytic 1, transcript variant X1.	0.859
A306_00003948	A306_00003949	A0A2I0MIQ1	A0A2I0MIJ9	Neurabin-1-like.	Neurabin-1-like.	0.816