(45 nodes) Spliceosomal snRNP complex network (Columba livia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SF3B5	Splicing factor 3b, subunit 5, 10kDa. (127 aa)
	SF3B6	Splicing factor 3b, subunit 6, 14kDa. (125 aa)
	TXNL4B	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
	A306_00004855	Putative RNA-binding protein Luc7-like 2. (250 aa)
	PHF5A	PHD finger protein 5A. (99 aa)
	SNU13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (272 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (107 aa)
	PRPF18	Pre-mRNA processing factor 18. (302 aa)
	LSM6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
	PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A, transcript variant X1. (870 aa)
	SNRPA1	Small nuclear ribonucleoprotein polypeptide A. (232 aa)
	SART3	Squamous cell carcinoma antigen recognized by T cells 3. (886 aa)
	LUC7L3	LUC7-like 3 pre-mRNA splicing factor. (498 aa)
	PRPF6	Pre-mRNA processing factor 6. (942 aa)
	HTATSF1	HIV-1 Tat specific factor 1. (435 aa)
	LUC7L	LUC7-like. (385 aa)
	A306_00008984	Small nuclear ribonucleoprotein-associated protein B'-like. (166 aa)
	PRPF8	Pre-mRNA processing factor 8. (2311 aa)
	SF3B3	Splicing factor 3b, subunit 3, 130kDa. (1217 aa)
	LSM5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3. (126 aa)
	SF3B1	Splicing factor 3b, subunit 1, 155kDa, transcript variant X3. (1301 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (109 aa)
	SNRPF	Small nuclear ribonucleoprotein polypeptide F. (143 aa)
	PRPF39	Pre-mRNA processing factor 39, transcript variant X1. (682 aa)
	SNRPG	Small nuclear ribonucleoprotein G. (64 aa)
	PRPF4	Pre-mRNA processing factor 4. (572 aa)
	TXNL4A	Thioredoxin-like 4A. (163 aa)
	SNRNP40	Small nuclear ribonucleoprotein 40kDa (U5). (348 aa)
	SF3A3	Splicing factor 3a, subunit 3, 60kDa. (399 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (112 aa)
	ZMAT2	Zinc finger, matrin-type 2. (208 aa)
	SF3A2	Splicing factor 3a, subunit 2, 66kDa. (211 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (207 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (148 aa)
	PRPF3	Pre-mRNA processing factor 3. (697 aa)
	DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Belongs to the DEAD box helicase family. (769 aa)
	SNRPC	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (266 aa)
	SNRNP200	Small nuclear ribonucleoprotein 200kDa (U5). (2105 aa)
	USP39	Ubiquitin specific peptidase 39. (394 aa)
	SF3A1	Splicing factor 3a, subunit 1, 120kDa. (810 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2. (63 aa)
	EFTUD2	116 kDa U5 small nuclear ribonucleoprotein component. (972 aa)
	SNRPB2	Small nuclear ribonucleoprotein polypeptide B. (226 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00004855	DDX23	A0A2I0MJX8	A0A2I0LKJ5	Putative RNA-binding protein Luc7-like 2.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Belongs to the DEAD box helicase family.	0.755
A306_00004855	EFTUD2	A0A2I0MJX8	R7VWQ8	Putative RNA-binding protein Luc7-like 2.	116 kDa U5 small nuclear ribonucleoprotein component.	0.462
A306_00004855	HTATSF1	A0A2I0MJX8	A0A2I0M4M3	Putative RNA-binding protein Luc7-like 2.	HIV-1 Tat specific factor 1.	0.518
A306_00004855	LUC7L3	A0A2I0MJX8	A0A2I0M719	Putative RNA-binding protein Luc7-like 2.	LUC7-like 3 pre-mRNA splicing factor.	0.505
A306_00004855	PHF5A	A0A2I0MJX8	A0A2I0MJL9	Putative RNA-binding protein Luc7-like 2.	PHD finger protein 5A.	0.603
A306_00004855	PRPF39	A0A2I0MJX8	A0A2I0LTP0	Putative RNA-binding protein Luc7-like 2.	Pre-mRNA processing factor 39, transcript variant X1.	0.810
A306_00004855	PRPF40A	A0A2I0MJX8	A0A2I0MG68	Putative RNA-binding protein Luc7-like 2.	PRP40 pre-mRNA processing factor 40 homolog A, transcript variant X1.	0.427
A306_00004855	SF3A1	A0A2I0MJX8	A0A2I0LI19	Putative RNA-binding protein Luc7-like 2.	Splicing factor 3a, subunit 1, 120kDa.	0.504
A306_00004855	SF3A2	A0A2I0MJX8	A0A2I0LQL0	Putative RNA-binding protein Luc7-like 2.	Splicing factor 3a, subunit 2, 66kDa.	0.491
A306_00004855	SF3A3	A0A2I0MJX8	A0A2I0LRT5	Putative RNA-binding protein Luc7-like 2.	Splicing factor 3a, subunit 3, 60kDa.	0.510
A306_00004855	SF3B1	A0A2I0MJX8	A0A2I0LXK2	Putative RNA-binding protein Luc7-like 2.	Splicing factor 3b, subunit 1, 155kDa, transcript variant X3.	0.746
A306_00004855	SF3B3	A0A2I0MJX8	A0A2I0M0G2	Putative RNA-binding protein Luc7-like 2.	Splicing factor 3b, subunit 3, 130kDa.	0.834
A306_00004855	SF3B5	A0A2I0MJX8	A0A2I0MV88	Putative RNA-binding protein Luc7-like 2.	Splicing factor 3b, subunit 5, 10kDa.	0.510
A306_00004855	SNRPA1	A0A2I0MJX8	A0A2I0MDH9	Putative RNA-binding protein Luc7-like 2.	Small nuclear ribonucleoprotein polypeptide A.	0.862
A306_00004855	SNRPB2	A0A2I0MJX8	R7VT62	Putative RNA-binding protein Luc7-like 2.	Small nuclear ribonucleoprotein polypeptide B.	0.633
A306_00004855	SNRPC	A0A2I0MJX8	A0A2I0LK23	Putative RNA-binding protein Luc7-like 2.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	0.924
A306_00004855	SNRPD1	A0A2I0MJX8	A0A2I0LRD2	Putative RNA-binding protein Luc7-like 2.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.828
A306_00004855	SNRPD2	A0A2I0MJX8	A0A2I0LFZ5	Putative RNA-binding protein Luc7-like 2.	Small nuclear ribonucleoprotein Sm D2.	0.834
A306_00004855	SNRPD3	A0A2I0MJX8	A0A2I0LZC7	Putative RNA-binding protein Luc7-like 2.	Small nuclear ribonucleoprotein Sm D3.	0.745
A306_00004855	SNRPE	A0A2I0MJX8	A0A2I0LMK8	Putative RNA-binding protein Luc7-like 2.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.872