STRINGSTRING
SMAD1 SMAD1 SMAD6 SMAD6 JUN JUN A306_00007614 A306_00007614 TGFB2 TGFB2 PRL PRL IL10 IL10 EGR1 EGR1 GNL3 GNL3 SMAD4 SMAD4 WT1 WT1 PDGFB PDGFB MKL1 MKL1 SREBF2 SREBF2 KLF5 KLF5 TERT TERT SREBF1 SREBF1 MKL2 MKL2 MYOCD MYOCD NGFR NGFR GATA2 GATA2 GATA3 GATA3 SRF SRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD1SMAD family member 1. (243 aa)
SMAD6Mothers against decapentaplegic homolog. (263 aa)
JUNJun proto-oncogene; Belongs to the bZIP family. (338 aa)
A306_00007614Krueppel-like factor 5. (435 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PRLProlactin. (229 aa)
IL10Interleukin 10. (176 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (480 aa)
GNL3Guanine nucleotide binding protein-like 3 (Nucleolar). (585 aa)
SMAD4Mothers against decapentaplegic homolog. (470 aa)
WT1Wilms tumor 1. (487 aa)
PDGFBPlatelet-derived growth factor beta polypeptide; Belongs to the PDGF/VEGF growth factor family. (256 aa)
MKL1Megakaryoblastic leukemia (Translocation) 1. (1187 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (448 aa)
KLF5Kruppel-like factor 5 (Intestinal). (365 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1257 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1025 aa)
MKL2MKL/myocardin-like 2. (1095 aa)
MYOCDMyocardin. (910 aa)
NGFRNerve growth factor receptor. (276 aa)
GATA2GATA binding protein 2. (433 aa)
GATA3GATA binding protein 3, transcript variant X1. (444 aa)
SRFSerum response factor isoform X2. (404 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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