STRINGSTRING
TNFSF10 TNFSF10 TXNDC12 TXNDC12 PDX1 PDX1 MAP2K5 MAP2K5 VIMP VIMP CTSH CTSH BCL10 BCL10 PTPRC PTPRC GCLM GCLM ITPRIP ITPRIP SIRT1 SIRT1 GHITM GHITM HELLS HELLS ACVR1 ACVR1 MARCH7 MARCH7 FAIM FAIM INHBB INHBB HGF HGF LRRK2 LRRK2 USP47 USP47 FADD FADD ACKR3 ACKR3 ZSWIM2 ZSWIM2 NFE2L2 NFE2L2 DNM1L DNM1L IGF1 IGF1 TIMP3 TIMP3 BCL2L14 BCL2L14 BID BID SLC25A6 SLC25A6 CASP2 CASP2 SLC25A4 SLC25A4 HTT HTT ING2 ING2 EIF2AK3 EIF2AK3 WFS1 WFS1 MSX1 MSX1 HMGB2 HMGB2 MADD MADD MAPK8IP1 MAPK8IP1 BAG5 BAG5 PSEN1 PSEN1 NDUFS3 NDUFS3 CREB3L1 CREB3L1 PTPMT1 PTPMT1 THBS1 THBS1 BDKRB2 BDKRB2 A306_00002562 A306_00002562 ZMYND11 ZMYND11 DFNA5 DFNA5 TPT1 TPT1 NCK2 NCK2 IL20RA IL20RA BCLAF1 BCLAF1 TPD52L1 TPD52L1 AGT AGT EYA4 EYA4 TNFAIP3 TNFAIP3 TMEM14A TMEM14A PRKN PRKN A306_00000615 A306_00000615 SOD2 SOD2 GCLC GCLC GFRAL GFRAL BCL2 BCL2 A306_00000010 A306_00000010 DEPTOR DEPTOR SNAI2 SNAI2 TERT TERT EYA1 EYA1 PTPN2 PTPN2 CLUL1 CLUL1 RIPK1 RIPK1 A306_00001428 A306_00001428 A306_00001162 A306_00001162 IL1B IL1B UNC5B UNC5B FAM167A FAM167A RB1CC1 RB1CC1 BAK1 BAK1 LCK LCK BRCA1 BRCA1 BCL2L1 BCL2L1 PLAGL2 PLAGL2 FAIM2 FAIM2 MCL1 MCL1 MUC1 MUC1 PEA15 PEA15 FXN FXN TMBIM6 TMBIM6 HYOU1 HYOU1 EYA3 EYA3 PRELID1 PRELID1 HTRA2 HTRA2 A306_00000308 A306_00000308 TRAF2 TRAF2 PPP2R1A PPP2R1A TMBIM1 TMBIM1 A306_00015004 A306_00015004 A306_00014960 A306_00014960 CREB3 CREB3 A306_00015172 A306_00015172 A306_00000452 A306_00000452 SLC35F6 SLC35F6 A306_00015231 A306_00015231 MPV17L MPV17L IVNS1ABP IVNS1ABP CTNNB1 CTNNB1 KDM1A KDM1A OPA1 OPA1 HERPUD1 HERPUD1 PIAS4 PIAS4 NDUFA13 NDUFA13 TMEM161A TMEM161A YJEFN3 YJEFN3 CFLAR CFLAR SH3RF1 SH3RF1 AR AR NGFR NGFR TRAF7 TRAF7 PARL PARL GDNF GDNF TP63 TP63 LGALS3 LGALS3 APAF1 APAF1 PTTG1IP PTTG1IP PAK2 PAK2 ITM2C ITM2C PIK3CB PIK3CB TRIM32 TRIM32 CRADD CRADD ZC3HC1 ZC3HC1 FBXW7 FBXW7 FGG FGG FAS FAS BIRC6 BIRC6 MNT MNT NLE1 NLE1 FAF1 FAF1 INHBA INHBA A306_00000071 A306_00000071 G0S2 G0S2 ACAA2 ACAA2 FLCN FLCN GPER1 GPER1 CTSC CTSC DDIAS DDIAS SIAH2 SIAH2 RFFL RFFL STYXL1 STYXL1 HSPB1 HSPB1 EYA2 EYA2 SNAI1 SNAI1 SRC SRC MMP9 MMP9 CYLD CYLD SIAH1 SIAH1 RPS3 RPS3 NOC2L NOC2L PINK1 PINK1 TRAF1 TRAF1 DBH DBH TRAP1 TRAP1 AGTR2 AGTR2 TGFBR1 TGFBR1 CAAP1 CAAP1 SRPX SRPX A306_00008277 A306_00008277 A306_00006775 A306_00006775 A306_00006777 A306_00006777 PDIA3 PDIA3 NOG NOG ATAD5 ATAD5 PLEKHF1 PLEKHF1 WWOX WWOX URI1 URI1 XBP1 XBP1 RNF34 RNF34 BMPR1B BMPR1B QARS QARS CD74 CD74 NME5 NME5 ATF3 ATF3 SLC25A5 SLC25A5 PSMD10 PSMD10 SKIL SKIL SCG2 SCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFSF10Tumor necrosis factor (Ligand) superfamily, member 10; Belongs to the tumor necrosis factor family. (194 aa)
TXNDC12Thioredoxin domain containing 12 (Endoplasmic reticulum). (115 aa)
PDX1Pancreatic and duodenal homeobox 1. (358 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (437 aa)
VIMPVCP-interacting membrane selenoprotein. (119 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (259 aa)
BCL10B-cell CLL/lymphoma 10. (214 aa)
PTPRCProtein tyrosine phosphatase, receptor type, C, transcript variant X1. (1247 aa)
GCLMGlutamate-cysteine ligase, modifier subunit. (312 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (457 aa)
SIRT1Sirtuin 1, transcript variant X1. (606 aa)
GHITMGrowth hormone inducible transmembrane protein; Belongs to the BI1 family. (346 aa)
HELLSHelicase, lymphoid-specific. (1012 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
MARCH7Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase, transcript variant X1. (800 aa)
FAIMFas apoptotic inhibitory molecule. (179 aa)
INHBBInhibin, beta B. (305 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
LRRK2Leucine-rich repeat kinase 2. (2447 aa)
USP47Ubiquitin specific peptidase 47, transcript variant X1; Belongs to the peptidase C19 family. (1361 aa)
FADDFas (TNFRSF6)-associated via death domain. (195 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ZSWIM2Zinc finger, SWIM-type containing 2. (566 aa)
NFE2L2Nuclear factor, erythroid 2-like 2. (582 aa)
DNM1LDynamin 1-like, transcript variant X3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (700 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C), transcript variant X1. (153 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (212 aa)
BCL2L14BCL2-like 14 (Apoptosis facilitator). (380 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (191 aa)
SLC25A6Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (281 aa)
CASP2Caspase 2, apoptosis-related cysteine peptidase, transcript variant X1; Belongs to the peptidase C14A family. (426 aa)
SLC25A4Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (278 aa)
HTTHuntingtin. (3078 aa)
ING2Inhibitor of growth protein. (288 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1004 aa)
WFS1Wolfram syndrome 1 (Wolframin). (293 aa)
MSX1Msh homeobox 1. (210 aa)
HMGB2High mobility group box 2. (207 aa)
MADDMAP-kinase activating death domain. (1357 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1, transcript variant X1. (489 aa)
BAG5BCL2-associated athanogene 5. (434 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
NDUFS3NADH dehydrogenase (Ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); Belongs to the complex I 30 kDa subunit family. (262 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (458 aa)
PTPMT1Protein tyrosine phosphatase, mitochondrial 1. (106 aa)
THBS1Thrombospondin 1. (997 aa)
BDKRB2Bradykinin receptor B2, transcript variant X1; Belongs to the G-protein coupled receptor 1 family. (410 aa)
A306_00002562Pituitary tumor-transforming gene 1 protein-interacting protein, transcript variant X1. (100 aa)
ZMYND11Zinc finger, MYND-type containing 11, transcript variant X1. (617 aa)
DFNA5Deafness, autosomal dominant 5. (366 aa)
TPT1Tumor protein, translationally-controlled 1; Belongs to the TCTP family. (138 aa)
NCK2Cytoplasmic protein. (380 aa)
IL20RAInterleukin 20 receptor, alpha. (550 aa)
BCLAF1BCL2-associated transcription factor 1, transcript variant X1. (920 aa)
TPD52L1Tumor protein D52-like 1, transcript variant X2. (181 aa)
AGTAngiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family. (463 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (616 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (809 aa)
TMEM14ATransmembrane protein 14A. (101 aa)
PRKNE3 ubiquitin-protein ligase parkin. (292 aa)
A306_00000615RBR-type E3 ubiquitin transferase. (233 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
GCLCGlutamate-cysteine ligase, catalytic subunit. (587 aa)
GFRALGDNF family receptor alpha like. (552 aa)
BCL2B-cell CLL/lymphoma 2. (138 aa)
A306_00000010Uncharacterized protein. (153 aa)
DEPTORDEP domain containing MTOR-interacting protein, transcript variant X1. (412 aa)
SNAI2Snail family zinc finger 2. (333 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1257 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (628 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (408 aa)
CLUL1Clusterin; Belongs to the clusterin family. (461 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (685 aa)
A306_00001428Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
A306_00001162Ubiquitin carboxyl-terminal hydrolase CYLD. (823 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (269 aa)
UNC5BUnc-5 netrin receptor B. (927 aa)
FAM167AFamily with sequence similarity 167, member A. (212 aa)
RB1CC1RB1-inducible coiled-coil protein 1. (1598 aa)
BAK1BCL2-antagonist/killer 1. (217 aa)
LCKTyrosine-protein kinase. (501 aa)
BRCA1Breast cancer 1, early onset. (1734 aa)
BCL2L1BCL2-like 1. (230 aa)
PLAGL2Pleiomorphic adenoma gene-like 2. (493 aa)
FAIM2Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (250 aa)
MCL1Myeloid cell leukemia 1. (224 aa)
MUC1Mucin 1, cell surface associated. (511 aa)
PEA15Phosphoprotein enriched in astrocytes 15. (158 aa)
FXNFrataxin, transcript variant X1. (136 aa)
TMBIM6Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (201 aa)
HYOU1Hypoxia up-regulated 1. (591 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (328 aa)
PRELID1PRELI domain containing 1. (192 aa)
HTRA2HtrA serine peptidase 2. (253 aa)
A306_00000308CLb domain-containing protein. (210 aa)
TRAF2TNF receptor-associated factor 2. (350 aa)
PPP2R1AProtein phosphatase 2, regulatory subunit A, alpha. (503 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (247 aa)
A306_00015004Pro-resilin. (653 aa)
A306_00014960RanBP-type and C3HC4-type zinc finger-containing protein 1-like. (681 aa)
CREB3cAMP responsive element binding protein 3. (438 aa)
A306_00015172F-box/WD repeat-containing protein 7. (357 aa)
A306_00000452Uncharacterized protein. (155 aa)
SLC35F6Uncharacterized protein. (93 aa)
A306_00015231Lysine-specific histone demethylase 1A-like. (151 aa)
MPV17LMPV17 mitochondrial membrane protein-like; Belongs to the peroxisomal membrane protein PXMP2/4 family. (92 aa)
IVNS1ABPInfluenza virus NS1A binding protein, transcript variant X1. (641 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (814 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (788 aa)
OPA1Optic atrophy 1 (Autosomal dominant); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1016 aa)
HERPUD1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1. (382 aa)
PIAS4Protein inhibitor of activated STAT, 4. (485 aa)
NDUFA13NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, 13. (109 aa)
TMEM161ATransmembrane protein 161A. (480 aa)
YJEFN3YjeF N-terminal domain containing 3. (189 aa)
CFLARCASP8 and FADD-like apoptosis regulator, transcript variant X1; Belongs to the peptidase C14A family. (487 aa)
SH3RF1SH3 domain containing ring finger 1. (768 aa)
ARAndrogen receptor. (458 aa)
NGFRNerve growth factor receptor. (276 aa)
TRAF7TNF receptor-associated factor 7, E3 ubiquitin protein ligase. (670 aa)
PARLPresenilin associated, rhomboid-like, transcript variant X2. (193 aa)
GDNFGlial cell derived neurotrophic factor, transcript variant X1. (218 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LGALS3Galectin. (246 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
PTTG1IPPituitary tumor-transforming 1 interacting protein. (153 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
ITM2CIntegral membrane protein 2C, transcript variant X1. (217 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
TRIM32Tripartite motif containing 32, transcript variant X1. (693 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (197 aa)
ZC3HC1Zinc finger, C3HC-type containing 1. (434 aa)
FBXW7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase. (487 aa)
FGGFibrinogen gamma chain. (436 aa)
FASFas cell surface death receptor. (399 aa)
BIRC6Baculoviral IAP repeat containing 6. (4774 aa)
MNTMAX network transcriptional repressor. (514 aa)
NLE1WD_REPEATS_REGION domain-containing protein. (478 aa)
FAF1Fas (TNFRSF6) associated factor 1. (733 aa)
INHBAInhibin, beta A. (424 aa)
A306_00000071Uncharacterized protein. (393 aa)
G0S2G0/G1 switch 2. (99 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
FLCNFolliculin. (579 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (475 aa)
DDIASDNA damage-induced apoptosis suppressor. (979 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (252 aa)
RFFLRing finger and FYVE-like domain containing E3 ubiquitin protein ligase, transcript variant X1. (393 aa)
STYXL1Serine/threonine/tyrosine interacting-like 1. (335 aa)
HSPB1Heat shock 27kDa protein 1; Belongs to the small heat shock protein (HSP20) family. (189 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (531 aa)
SNAI1Snail family zinc finger 1. (247 aa)
SRCSRC proto-oncogene, non-receptor tyrosine kinase. (320 aa)
MMP9Matrix metallopeptidase 9. (734 aa)
CYLDCylindromatosis (Turban tumor syndrome); Belongs to the peptidase C19 family. (949 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (306 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NOC2LNOC2-like nucleolar associated transcriptional repressor. (779 aa)
PINK1PTEN induced putative kinase 1. (521 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
DBHDopamine beta-hydroxylase (Dopamine beta-monooxygenase). (516 aa)
TRAP1TNF receptor-associated protein 1. (677 aa)
AGTR2Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CAAP1Caspase activity and apoptosis inhibitor 1. (215 aa)
SRPXSushi-repeat containing protein, X-linked. (494 aa)
A306_00008277DEP domain-containing mTOR-interacting protein. (440 aa)
A306_00006775Protein PML. (586 aa)
A306_00006777Protein PML. (739 aa)
PDIA3Protein disulfide-isomerase. (463 aa)
NOGNoggin. (216 aa)
ATAD5ATPase family, AAA domain containing 5. (1851 aa)
PLEKHF1Pleckstrin homology domain containing, family F (With FYVE domain) member 1. (273 aa)
WWOXWW domain containing oxidoreductase. (338 aa)
URI1URI1, prefoldin-like chaperone. (523 aa)
XBP1X-box binding protein 1. (197 aa)
RNF34Ring finger protein 34, E3 ubiquitin protein ligase. (235 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
QARSGlutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (733 aa)
CD74CD74 molecule, major histocompatibility complex, class II invariant chain, transcript variant X1. (278 aa)
NME5NME/NM23 family member 5, transcript variant X2; Belongs to the NDK family. (213 aa)
ATF3Activating transcription factor 3, transcript variant X1. (218 aa)
SLC25A5Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (271 aa)
PSMD10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (217 aa)
SKILSKI-like proto-oncogene. (690 aa)
SCG2Secretogranin II. (626 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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