61 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A306_00015172	F-box/WD repeat-containing protein 7. (357 aa)
	A306_00014960	RanBP-type and C3HC4-type zinc finger-containing protein 1-like. (681 aa)
	PPP2R1A	Protein phosphatase 2, regulatory subunit A, alpha. (503 aa)
	HTRA2	HtrA serine peptidase 2. (253 aa)
	PEA15	Phosphoprotein enriched in astrocytes 15. (158 aa)
	PLAGL2	Pleiomorphic adenoma gene-like 2. (493 aa)
	LCK	Tyrosine-protein kinase. (501 aa)
	PIAS4	Protein inhibitor of activated STAT, 4. (485 aa)
	NGFR	Nerve growth factor receptor. (276 aa)
	TRAF7	TNF receptor-associated factor 7, E3 ubiquitin protein ligase. (670 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	PAK2	Non-specific serine/threonine protein kinase. (525 aa)
	ITM2C	Integral membrane protein 2C, transcript variant X1. (217 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (197 aa)
	FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase. (487 aa)
	FAS	Fas cell surface death receptor. (399 aa)
	FAF1	Fas (TNFRSF6) associated factor 1. (733 aa)
	INHBA	Inhibin, beta A. (424 aa)
	G0S2	G0/G1 switch 2. (99 aa)
	FLCN	Folliculin. (579 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	CTSC	Cathepsin C; Belongs to the peptidase C1 family. (475 aa)
	STYXL1	Serine/threonine/tyrosine interacting-like 1. (335 aa)
	CYLD	Cylindromatosis (Turban tumor syndrome); Belongs to the peptidase C19 family. (949 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	AGTR2	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	SRPX	Sushi-repeat containing protein, X-linked. (494 aa)
	A306_00006775	Protein PML. (586 aa)
	A306_00006777	Protein PML. (739 aa)
	PDIA3	Protein disulfide-isomerase. (463 aa)
	PLEKHF1	Pleckstrin homology domain containing, family F (With FYVE domain) member 1. (273 aa)
	WWOX	WW domain containing oxidoreductase. (338 aa)
	BMPR1B	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	ATF3	Activating transcription factor 3, transcript variant X1. (218 aa)
	SKIL	SKI-like proto-oncogene. (690 aa)
	TNFSF10	Tumor necrosis factor (Ligand) superfamily, member 10; Belongs to the tumor necrosis factor family. (194 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (259 aa)
	BCL10	B-cell CLL/lymphoma 10. (214 aa)
	PTPRC	Protein tyrosine phosphatase, receptor type, C, transcript variant X1. (1247 aa)
	SIRT1	Sirtuin 1, transcript variant X1. (606 aa)
	INHBB	Inhibin, beta B. (305 aa)
	FADD	Fas (TNFRSF6)-associated via death domain. (195 aa)
	ZSWIM2	Zinc finger, SWIM-type containing 2. (566 aa)
	DNM1L	Dynamin 1-like, transcript variant X3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (700 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (212 aa)
	BCL2L14	BCL2-like 14 (Apoptosis facilitator). (380 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (191 aa)
	CASP2	Caspase 2, apoptosis-related cysteine peptidase, transcript variant X1; Belongs to the peptidase C14A family. (426 aa)
	MSX1	Msh homeobox 1. (210 aa)
	THBS1	Thrombospondin 1. (997 aa)
	DFNA5	Deafness, autosomal dominant 5. (366 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	IL20RA	Interleukin 20 receptor, alpha. (550 aa)
	BCLAF1	BCL2-associated transcription factor 1, transcript variant X1. (920 aa)
	TPD52L1	Tumor protein D52-like 1, transcript variant X2. (181 aa)
	AGT	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family. (463 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (408 aa)
	RIPK1	Receptor (TNFRSF)-interacting serine-threonine kinase 1. (685 aa)
	A306_00001162	Ubiquitin carboxyl-terminal hydrolase CYLD. (823 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00001162	A306_00014960	A0A2I0MXZ0	A0A2I0LHY1	Ubiquitin carboxyl-terminal hydrolase CYLD.	RanBP-type and C3HC4-type zinc finger-containing protein 1-like.	0.578
A306_00001162	CYLD	A0A2I0MXZ0	A0A2I0M2H6	Ubiquitin carboxyl-terminal hydrolase CYLD.	Cylindromatosis (Turban tumor syndrome); Belongs to the peptidase C19 family.	0.903
A306_00001162	FADD	A0A2I0MXZ0	A0A2I0MI45	Ubiquitin carboxyl-terminal hydrolase CYLD.	Fas (TNFRSF6)-associated via death domain.	0.600
A306_00001162	RIPK1	A0A2I0MXZ0	A0A2I0MXV2	Ubiquitin carboxyl-terminal hydrolase CYLD.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.985
A306_00001162	TRAF7	A0A2I0MXZ0	A0A2I0LTK0	Ubiquitin carboxyl-terminal hydrolase CYLD.	TNF receptor-associated factor 7, E3 ubiquitin protein ligase.	0.444
A306_00006775	A306_00006777	A0A2I0M6J2	A0A2I0M6J3	Protein PML.	Protein PML.	0.903
A306_00006777	A306_00006775	A0A2I0M6J3	A0A2I0M6J2	Protein PML.	Protein PML.	0.903
A306_00014960	A306_00001162	A0A2I0LHY1	A0A2I0MXZ0	RanBP-type and C3HC4-type zinc finger-containing protein 1-like.	Ubiquitin carboxyl-terminal hydrolase CYLD.	0.578
A306_00014960	CYLD	A0A2I0LHY1	A0A2I0M2H6	RanBP-type and C3HC4-type zinc finger-containing protein 1-like.	Cylindromatosis (Turban tumor syndrome); Belongs to the peptidase C19 family.	0.578
A306_00014960	RIPK1	A0A2I0LHY1	A0A2I0MXV2	RanBP-type and C3HC4-type zinc finger-containing protein 1-like.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.738
AGT	AGTR2	A0A2I0MTU8	A0A2I0M4I9	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family.	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family.	0.999
AGT	CTSC	A0A2I0MTU8	A0A2I0M133	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family.	Cathepsin C; Belongs to the peptidase C1 family.	0.578
AGT	CTSH	A0A2I0MTU8	A0A2I0MDM6	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family.	Cathepsin H; Belongs to the peptidase C1 family.	0.430
AGT	GPER1	A0A2I0MTU8	A0A2I0M0W3	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family.	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.661
AGTR2	AGT	A0A2I0M4I9	A0A2I0MTU8	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family.	Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family.	0.999
AGTR2	TIMP3	A0A2I0M4I9	A0A2I0MK81	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family.	TIMP metallopeptidase inhibitor 3.	0.406
APAF1	BCL2L14	A0A2I0LUL5	A0A2I0MKP1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2-like 14 (Apoptosis facilitator).	0.648
APAF1	CASP2	A0A2I0LUL5	A0A2I0MLS1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2, apoptosis-related cysteine peptidase, transcript variant X1; Belongs to the peptidase C14A family.	0.864
APAF1	FADD	A0A2I0LUL5	A0A2I0MI45	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas (TNFRSF6)-associated via death domain.	0.549
APAF1	HTRA2	A0A2I0LUL5	A0A2I0LJL6	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HtrA serine peptidase 2.	0.470