63 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OPRM1	Opioid receptor, mu 1; Belongs to the G-protein coupled receptor 1 family. (327 aa)
	PDE4C-2	cAMP-specific 3',5'-cyclic phosphodiesterase 4D; Belongs to the cyclic nucleotide phosphodiesterase family. (233 aa)
	PDE1B	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (268 aa)
	GNAI2	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (303 aa)
	CDK5	Cyclin-dependent kinase 5. (196 aa)
	PPP2R1A	Protein phosphatase 2, regulatory subunit A, alpha. (503 aa)
	PDE4A	Phosphodiesterase. (614 aa)
	A306_00014120	Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (333 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
	PPP1R1B	Protein phosphatase 1, regulatory (Inhibitor) subunit 1B. (120 aa)
	GNA11	Guanine nucleotide-binding protein subunit alpha-11. (390 aa)
	PDE4C	Phosphodiesterase. (692 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1210 aa)
	PLA2G4A	Phospholipase A2. (749 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
	GNG13	Guanine nucleotide binding protein (G protein), gamma 13. (67 aa)
	SNX19	Sorting nexin 19. (937 aa)
	ADCY3	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (840 aa)
	POMC	Proopiomelanocortin. (220 aa)
	GNAI3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (343 aa)
	GNAO1	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O. (322 aa)
	PRKAR1B	Protein kinase, cAMP-dependent, regulatory, type I, beta. (381 aa)
	CAMKK1	Calcium/calmodulin-dependent protein kinase kinase 1, alpha, transcript variant X1. (553 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
	GNB1	Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1346 aa)
	PDE1C	Phosphodiesterase. (673 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1020 aa)
	PDE4D	Phosphodiesterase. (665 aa)
	PDYN	Prodynorphin. (283 aa)
	PRKAR1A	Protein kinase, cAMP-dependent, regulatory, type I, alpha, transcript variant X1. (382 aa)
	PRKCA	Protein kinase C, alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (615 aa)
	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2, beta, transcript variant X1. (521 aa)
	CAMK4	Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. (346 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1243 aa)
	PRKAR2A	Protein kinase, cAMP-dependent, regulatory, type II, alpha. (378 aa)
	GNB4	Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	PDE4B	Phosphodiesterase. (659 aa)
	NBEA	Neurobeachin. (1671 aa)
	DCLK1	Doublecortin-like kinase 1, transcript variant X1. (729 aa)
	GNB5	Guanine nucleotide binding protein (G protein), beta 5. (388 aa)
	PRKACB	Protein kinase, cAMP-dependent, catalytic, beta, transcript variant X1; Belongs to the protein kinase superfamily. (398 aa)
	A306_00007955	Guanine nucleotide-binding protein G(Q) subunit alpha. (287 aa)
	A306_00007954	Guanine nucleotide-binding protein subunit alpha-14. (301 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1216 aa)
	LRBA	LPS-responsive vesicle trafficking, beach and anchor containing. (2146 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa)
	PRKAR2B	Protein kinase, cAMP-dependent, regulatory, type II, beta. (324 aa)
	GNAI1	Guanine nucleotide-binding protein G(I) subunit alpha-1. (302 aa)
	PDE1A	Phosphodiesterase. (661 aa)
	PRKX	Protein kinase, X-linked. (321 aa)
	GNB3	Guanine nucleotide binding protein (G protein), beta polypeptide 3. (340 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	A306_00002580	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	GNAL	LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha. (320 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1184 aa)
	ADCY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1055 aa)
	THAP1	THAP domain containing, apoptosis associated protein 1. (238 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00002580	A306_00007954	A0A2I0MQA5	A0A2I0MFX9	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit alpha-14.	0.594
A306_00002580	A306_00007955	A0A2I0MQA5	A0A2I0MFX1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.594
A306_00002580	ADCY1	A0A2I0MQA5	A0A2I0M4U6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.859
A306_00002580	ADCY2	A0A2I0MQA5	A0A2I0MXG6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.769
A306_00002580	ADCY3	A0A2I0MQA5	A0A2I0LVT8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.839
A306_00002580	ADCY5	A0A2I0MQA5	A0A2I0MGJ7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.801
A306_00002580	ADCY6	A0A2I0MQA5	A0A2I0LKK0	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.801
A306_00002580	ADCY7	A0A2I0MQA5	A0A2I0M2G7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.769
A306_00002580	ADCY8	A0A2I0MQA5	A0A2I0MW10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.560
A306_00002580	ADCY9	A0A2I0MQA5	A0A2I0M495	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.841
A306_00002580	GNA11	A0A2I0MQA5	A0A2I0LPS8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit alpha-11.	0.594
A306_00002580	GNAI1	A0A2I0MQA5	A0A2I0MHJ3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I) subunit alpha-1.	0.705
A306_00002580	GNAI2	A0A2I0MQA5	A0A2I0LHY4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.705
A306_00002580	GNAI3	A0A2I0MQA5	A0A2I0LZU9	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.705
A306_00002580	GNAL	A0A2I0MQA5	A0A2I0MVV9	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha.	0.634
A306_00002580	GNAO1	A0A2I0MQA5	A0A2I0M0I5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O.	0.705
A306_00002580	GNB1	A0A2I0MQA5	A0A2I0M2Z5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.928
A306_00002580	GNB3	A0A2I0MQA5	A0A2I0MLQ6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta polypeptide 3.	0.888
A306_00002580	GNB4	A0A2I0MQA5	A0A2I0MBA5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta polypeptide 4.	0.928
A306_00002580	GNB5	A0A2I0MQA5	A0A2I0MDM8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta 5.	0.864