37 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
	GRB2	Growth factor receptor-bound protein 2. (250 aa)
	ADAP2	ArfGAP with dual PH domains 2. (291 aa)
	NEDD4	E3 ubiquitin-protein ligase NEDD4 isoform X2. (1301 aa)
	NRG4	Neuregulin 4, transcript variant X1. (116 aa)
	NRG1	Neuregulin 1, transcript variant X1. (685 aa)
	SRC	SRC proto-oncogene, non-receptor tyrosine kinase. (320 aa)
	ADAP1	ArfGAP with dual PH domains 1. (352 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (796 aa)
	SOS1	Uncharacterized protein. (1323 aa)
	A306_00011441	Fibronectin type-III domain-containing protein 3a-like, transcript variant X1. (1189 aa)
	STMN1	Stathmin; Belongs to the stathmin family. (148 aa)
	BTC	Betacellulin. (213 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	NCSTN	Nicastrin. (703 aa)
	ITCH	E3 ubiquitin-protein ligase. (890 aa)
	A306_00014977	Signal transducer and activator of transcription 5B. (703 aa)
	A306_00000355	Uncharacterized protein. (167 aa)
	A306_00000389	IF rod domain-containing protein; Belongs to the intermediate filament family. (202 aa)
	EGF	Epidermal growth factor. (1254 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	NRG2	Neuregulin 2. (466 aa)
	HBEGF	Heparin-binding EGF-like growth factor. (158 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	FNDC3B	Uncharacterized protein. (1154 aa)
	NRG3	Neuregulin 3. (377 aa)
	EREG	Epiregulin. (118 aa)
	HRAS	Uncharacterized protein. (189 aa)
	KRAS	Uncharacterized protein. (197 aa)
	MXD4	MAX dimerization protein 4. (520 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
	FNDC3A	Fibronectin type III domain containing 3A, transcript variant X1. (1199 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
	WWP1	E3 ubiquitin-protein ligase. (925 aa)
	A306_00004944	Arf-GAP with dual PH domain-containing protein 1. (378 aa)
	WWOX	WW domain containing oxidoreductase. (338 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000355	NCSTN	A0A2I0LH05	A0A2I0LLC9	Uncharacterized protein.	Nicastrin.	0.997
A306_00000355	PSEN1	A0A2I0LH05	A0A2I0MNS4	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.993
A306_00000355	PSEN2	A0A2I0LH05	R7VWX4	Uncharacterized protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.991
A306_00000389	EGF	A0A2I0LGF1	A0A2I0M930	IF rod domain-containing protein; Belongs to the intermediate filament family.	Epidermal growth factor.	0.527
A306_00014977	SRC	A0A2I0LHC5	A0A2I0M2A8	Signal transducer and activator of transcription 5B.	SRC proto-oncogene, non-receptor tyrosine kinase.	0.537
BTC	EGF	A0A2I0LMD4	A0A2I0M930	Betacellulin.	Epidermal growth factor.	0.774
BTC	EREG	A0A2I0LMD4	A0A2I0MGS1	Betacellulin.	Epiregulin.	0.776
BTC	GRB2	A0A2I0LMD4	A0A2I0M7L1	Betacellulin.	Growth factor receptor-bound protein 2.	0.518
BTC	HBEGF	A0A2I0LMD4	A0A2I0MAA3	Betacellulin.	Heparin-binding EGF-like growth factor.	0.754
BTC	NRG1	A0A2I0LMD4	A0A2I0M6D3	Betacellulin.	Neuregulin 1, transcript variant X1.	0.504
BTC	NRG2	A0A2I0LMD4	A0A2I0MA98	Betacellulin.	Neuregulin 2.	0.504
BTC	SRC	A0A2I0LMD4	A0A2I0M2A8	Betacellulin.	SRC proto-oncogene, non-receptor tyrosine kinase.	0.434
CSDE1	EGF	A0A2I0LZZ5	A0A2I0M930	Cold shock domain containing E1, RNA-binding.	Epidermal growth factor.	0.414
CSDE1	GRB2	A0A2I0LZZ5	A0A2I0M7L1	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2.	0.623
CSDE1	PIK3CA	A0A2I0LZZ5	A0A2I0MBJ9	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.695
CSDE1	RPS27A	A0A2I0LZZ5	A0A2I0M9A1	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.454
CSDE1	SOS1	A0A2I0LZZ5	A0A2I0LT24	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.676
CSDE1	SRC	A0A2I0LZZ5	A0A2I0M2A8	Cold shock domain containing E1, RNA-binding.	SRC proto-oncogene, non-receptor tyrosine kinase.	0.415
EGF	A306_00000389	A0A2I0M930	A0A2I0LGF1	Epidermal growth factor.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.527
EGF	BTC	A0A2I0M930	A0A2I0LMD4	Epidermal growth factor.	Betacellulin.	0.774