73 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A306_00014953	Chromodomain-helicase-DNA-binding protein 3-like. (524 aa)
	NTRK1	Neurotrophic tyrosine kinase, receptor, type 1. (272 aa)
	PPP2R1A	Protein phosphatase 2, regulatory subunit A, alpha. (503 aa)
	FNBP4	WW domain-containing protein. (479 aa)
	CHD5	Chromodomain helicase DNA binding protein 5. (1014 aa)
	SHC2	SHC (Src homology 2 domain containing) transforming protein 2. (403 aa)
	MAPK15	Mitogen-activated protein kinase. (524 aa)
	A306_00014013	Mitogen-activated protein kinase. (182 aa)
	RPS6KA1	Ribosomal protein S6 kinase, 90kDa, polypeptide 1. (773 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	RIT1	Ras-like without CAAX 1, transcript variant X1. (206 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
	ID3	Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (97 aa)
	ATF1	Activating transcription factor 1. (314 aa)
	AP2M1	Adaptor-related protein complex 2, mu 1 subunit; Belongs to the adaptor complexes medium subunit family. (433 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	MAPKAPK3	Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (387 aa)
	DUSP7	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (317 aa)
	SOS1	Uncharacterized protein. (1323 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (480 aa)
	EGR3	Early growth response 3. (341 aa)
	RALA	V-ral simian leukemia viral oncogene homolog A (Ras related), transcript variant X1. (206 aa)
	SRF	Serum response factor isoform X2. (404 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (353 aa)
	VRK3	Vaccinia related kinase 3. (332 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1651 aa)
	CRKL	V-crk avian sarcoma virus CT10 oncogene homolog-like. (369 aa)
	MAPKAPK2	Mitogen-activated protein kinase-activated protein kinase 2. (309 aa)
	NGF	Nerve growth factor (Beta polypeptide); Belongs to the NGF-beta family. (267 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (796 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	RIT2	Ras-like without CAAX 2. (217 aa)
	CRK	V-crk avian sarcoma virus CT10 oncogene homolog. (306 aa)
	YWHAB	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta; Belongs to the 14-3-3 family. (244 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1. (1032 aa)
	A306_00008325	Serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (551 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (244 aa)
	GRB2	Growth factor receptor-bound protein 2. (250 aa)
	RRAD	Ras-related associated with diabetes. (285 aa)
	MAPK1	Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	MAP2K5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (437 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	SHC4	SHC (Src homology 2 domain containing) family, member 4. (621 aa)
	SH3GL2	SH3-domain GRB2-like 2. (317 aa)
	SHC3	SHC (Src homology 2 domain containing) transforming protein 3. (632 aa)
	RALB	V-ral simian leukemia viral oncogene homolog B, transcript variant X1. (206 aa)
	A306_00007179	Mitogen-activated protein kinase 11. (75 aa)
	A306_00007180	Mitogen-activated protein kinase. (221 aa)
	HRAS	Uncharacterized protein. (189 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (960 aa)
	NAB1	NGFI-A binding protein 1 (EGR1 binding protein 1). (208 aa)
	DNAL4	Dynein light chain. (106 aa)
	KRAS	Uncharacterized protein. (197 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase, transcript variant X1. (754 aa)
	CHD4	Chromodomain helicase DNA binding protein 4, transcript variant X1. (1939 aa)
	RPS6KA3	Non-specific serine/threonine protein kinase. (707 aa)
	EGR4	Early growth response 4. (392 aa)
	PPP4R4	Protein phosphatase 4, regulatory subunit 4. (875 aa)
	RPS6KA5	Ribosomal protein S6 kinase, 90kDa, polypeptide 5. (765 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (733 aa)
	SGK1	Non-specific serine/threonine protein kinase. (517 aa)
	TRIB2	Tribbles pseudokinase 2. (343 aa)
	KIDINS220	Kinase D-interacting substrate, 220kDa, transcript variant X1. (1782 aa)
	ID2	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, transcript variant X1. (134 aa)
	PPP4R1	Protein phosphatase 4, regulatory subunit 1. (935 aa)
	TRIB1	Tribbles pseudokinase 1. (253 aa)
	A306_00001775	KIAA1468 ortholog. (1071 aa)
	ARC	Activity-regulated cytoskeleton-associated protein. (404 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	A306_00014015	Mitogen-activated protein kinase. (167 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00007179	AP2M1	A0A2I0MHA4	A0A2I0LPH6	Mitogen-activated protein kinase 11.	Adaptor-related protein complex 2, mu 1 subunit; Belongs to the adaptor complexes medium subunit family.	0.421
A306_00007179	BRAF	A0A2I0MHA4	A0A2I0MKF7	Mitogen-activated protein kinase 11.	B-Raf proto-oncogene, serine/threonine kinase, transcript variant X1.	0.436
A306_00007179	DUSP6	A0A2I0MHA4	A0A2I0LWD7	Mitogen-activated protein kinase 11.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.526
A306_00007179	DUSP7	A0A2I0MHA4	A0A2I0LSN7	Mitogen-activated protein kinase 11.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.526
A306_00007179	MAP2K1	A0A2I0MHA4	A0A2I0MD87	Mitogen-activated protein kinase 11.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.630
A306_00007179	MAP2K5	A0A2I0MHA4	A0A2I0MD82	Mitogen-activated protein kinase 11.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.630
A306_00007179	MAPK1	A0A2I0MHA4	A0A2I0M868	Mitogen-activated protein kinase 11.	Mitogen-activated protein kinase 1, transcript variant X2.	0.453
A306_00007179	MAPKAPK2	A0A2I0MHA4	A0A2I0LZX9	Mitogen-activated protein kinase 11.	Mitogen-activated protein kinase-activated protein kinase 2.	0.795
A306_00007179	MAPKAPK3	A0A2I0MHA4	A0A2I0LRA9	Mitogen-activated protein kinase 11.	Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily.	0.785
A306_00007179	RPS6KA5	A0A2I0MHA4	A0A2I0MQ34	Mitogen-activated protein kinase 11.	Ribosomal protein S6 kinase, 90kDa, polypeptide 5.	0.631
A306_00007180	AP2M1	A0A2I0MHJ1	A0A2I0LPH6	Mitogen-activated protein kinase.	Adaptor-related protein complex 2, mu 1 subunit; Belongs to the adaptor complexes medium subunit family.	0.421
A306_00007180	BRAF	A0A2I0MHJ1	A0A2I0MKF7	Mitogen-activated protein kinase.	B-Raf proto-oncogene, serine/threonine kinase, transcript variant X1.	0.436
A306_00007180	DUSP3	A0A2I0MHJ1	A0A2I0LNC1	Mitogen-activated protein kinase.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.933
A306_00007180	DUSP6	A0A2I0MHJ1	A0A2I0LWD7	Mitogen-activated protein kinase.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.526
A306_00007180	DUSP7	A0A2I0MHJ1	A0A2I0LSN7	Mitogen-activated protein kinase.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.827
A306_00007180	MAP2K1	A0A2I0MHJ1	A0A2I0MD87	Mitogen-activated protein kinase.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.651
A306_00007180	MAP2K5	A0A2I0MHJ1	A0A2I0MD82	Mitogen-activated protein kinase.	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.651
A306_00007180	MAPK1	A0A2I0MHJ1	A0A2I0M868	Mitogen-activated protein kinase.	Mitogen-activated protein kinase 1, transcript variant X2.	0.944
A306_00007180	MAPKAPK2	A0A2I0MHJ1	A0A2I0LZX9	Mitogen-activated protein kinase.	Mitogen-activated protein kinase-activated protein kinase 2.	0.980
A306_00007180	MAPKAPK3	A0A2I0MHJ1	A0A2I0LRA9	Mitogen-activated protein kinase.	Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily.	0.979