75 items (Columba livia) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	POLR2K	Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa. (58 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (313 aa)
	GTF2F2	General transcription factor IIF, polypeptide 2, 30kDa, transcript variant X2. (322 aa)
	FNDC3A	Fibronectin type III domain containing 3A, transcript variant X1. (1199 aa)
	FLRT2	Fibronectin leucine rich transmembrane protein 2. (662 aa)
	SPRED1	Sprouty-related, EVH1 domain containing 1, transcript variant X1. (414 aa)
	FGFBP1	Fibroblast growth factor binding protein 1. (238 aa)
	FGFBP2	Fibroblast growth factor binding protein 2. (208 aa)
	FGFRL1	Fibroblast growth factor receptor-like 1. (525 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (122 aa)
	FGFR3	Fibroblast growth factor receptor. (782 aa)
	KLB	Klotho beta. (987 aa)
	ANOS1	Anosmin 1. (437 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (254 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase, transcript variant X1. (754 aa)
	KRAS	Uncharacterized protein. (197 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	RBFOX2	RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (384 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (157 aa)
	HRAS	Uncharacterized protein. (189 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	POLR2L	Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa. (67 aa)
	GAB1	GRB2-associated binding protein 1. (718 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
	TIAL1	TIA1 cytotoxic granule-associated RNA binding protein-like 1, transcript variant X1. (384 aa)
	FGFR2	Fibroblast growth factor receptor. (843 aa)
	PTBP2	Polypyrimidine tract binding protein 2. (349 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	KL	Klotho. (955 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	A306_00007698	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (161 aa)
	FNDC3B	Uncharacterized protein. (1154 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (123 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	SPRED2	Sprouty-related, EVH1 domain containing 2. (409 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	PTPN11	Protein tyrosine phosphatase, non-receptor type 11. (587 aa)
	ESRP2	Epithelial splicing regulatory protein 2, transcript variant X1. (729 aa)
	GRB2	Growth factor receptor-bound protein 2. (250 aa)
	PTBP3	Polypyrimidine tract binding protein 3. (197 aa)
	NCBP1	Nuclear cap binding protein subunit 1, 80kDa. (772 aa)
	A306_00009263	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (138 aa)
	A306_00006107	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	POLR2J	Polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa. (148 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (796 aa)
	STIL	SCL/TAL1 interrupting locus protein. (294 aa)
	MKNK1	MAP kinase interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (438 aa)
	POLR2B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1167 aa)
	CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase. (909 aa)
	POLR2D	Polymerase (RNA) II (DNA directed) polypeptide D. (161 aa)
	TIA1	TIA1 cytotoxic granule-associated RNA binding protein. (401 aa)
	SOS1	Uncharacterized protein. (1323 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	A306_00011441	Fibronectin type-III domain-containing protein 3a-like, transcript variant X1. (1189 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	POLR2C	Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa. (244 aa)
	MKNK2	MAP kinase interacting serine/threonine kinase 2. (246 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (469 aa)
	HNRNPM	Heterogeneous nuclear ribonucleoprotein M. (593 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	POLR2I	Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa. (90 aa)
	GTF2F1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (214 aa)
	A306_00000187	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (549 aa)
	POLR2H	Polymerase (RNA) II (DNA directed) polypeptide H. (114 aa)
	A306_00015223	Putative LOC102091525. (404 aa)
	PTBP1	Polypyrimidine tract binding protein 1. (574 aa)
	FGFR4	Fibroblast growth factor receptor. (822 aa)
	POLR2E	Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa. (139 aa)
	ESRP1	Epithelial splicing regulatory protein 1. (404 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000187	A306_00006107	A0A2I0LH72	A0A2I0M3D4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.437
A306_00000187	ANOS1	A0A2I0LH72	A0A2I0MKY6	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Anosmin 1.	0.836
A306_00000187	CBL	A0A2I0LH72	A0A2I0LVE4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.426
A306_00000187	FGF1	A0A2I0LH72	A0A2I0LTA7	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.937
A306_00000187	FGF16	A0A2I0LH72	A0A2I0MB00	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.657
A306_00000187	FGF17	A0A2I0LH72	A0A2I0LR08	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
A306_00000187	FGF18	A0A2I0LH72	A0A2I0LSP8	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.710
A306_00000187	FGF19	A0A2I0LH72	A0A2I0MHQ5	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.808
A306_00000187	FGF20	A0A2I0LH72	A0A2I0MMT3	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.657
A306_00000187	FGF23	A0A2I0LH72	A0A2I0MKG9	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.854
A306_00000187	FGF3	A0A2I0LH72	A0A2I0MI44	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.677
A306_00000187	FGF4	A0A2I0LH72	A0A2I0MI38	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.715
A306_00000187	FGF5	A0A2I0LH72	A0A2I0MH20	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.710
A306_00000187	FGF6	A0A2I0LH72	A0A2I0MKD0	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.670
A306_00000187	FGF7	A0A2I0LH72	A0A2I0MDN6	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.744
A306_00000187	FGF8	A0A2I0LH72	A0A2I0LP43	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.869
A306_00000187	FGF9	A0A2I0LH72	A0A2I0MCY0	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.737
A306_00000187	FGFR3	A0A2I0LH72	A0A2I0MMC5	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor receptor.	0.483
A306_00000187	FGFR4	A0A2I0LH72	A0A2I0LK09	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor receptor.	0.528
A306_00000187	FLRT2	A0A2I0LH72	A0A2I0MP77	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibronectin leucine rich transmembrane protein 2.	0.516