25 items (Columba livia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	GRAP2	GRB2-related adaptor protein 2, transcript variant X1. (296 aa)
	A306_00015346	Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family. (177 aa)
	VAV1	Vav 1 guanine nucleotide exchange factor. (690 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	SOS1	Uncharacterized protein. (1323 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	A306_00010002	Natural killer cells antigen CD94. (233 aa)
	A306_00010010	Killer cell lectin-like receptor subfamily G member 1. (189 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (796 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1245 aa)
	SIGLEC15	Sialic acid binding Ig-like lectin 15. (281 aa)
	SPNS3	MFS domain-containing protein. (498 aa)
	VAV2	Vav 2 guanine nucleotide exchange factor. (878 aa)
	SYK	Tyrosine-protein kinase. (617 aa)
	GRB2	Growth factor receptor-bound protein 2. (250 aa)
	A306_00006360	CMRF35-like molecule 6. (319 aa)
	LCP2	Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa). (354 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	VAV3	Vav 3 guanine nucleotide exchange factor. (834 aa)
	HRAS	Uncharacterized protein. (189 aa)
	KRAS	Uncharacterized protein. (197 aa)
	A306_00001163	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1300 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00001163	GRAP2	A0A2I0MXY9	A0A2I0MJS2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	GRB2-related adaptor protein 2, transcript variant X1.	0.764
A306_00001163	GRB2	A0A2I0MXY9	A0A2I0M7L1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Growth factor receptor-bound protein 2.	0.850
A306_00001163	LCP2	A0A2I0MXY9	A0A2I0M9Z1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa).	0.772
A306_00001163	PIK3CA	A0A2I0MXY9	A0A2I0MBJ9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.741
A306_00001163	PIK3CB	A0A2I0MXY9	A0A2I0LW23	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.741
A306_00001163	PIK3R2	A0A2I0MXY9	A0A2I0LQ03	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta).	0.729
A306_00001163	PLCG2	A0A2I0MXY9	A0A2I0M0A9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.902
A306_00001163	SHC1	A0A2I0MXY9	A0A2I0LM13	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	SHC (Src homology 2 domain containing) transforming protein 1.	0.586
A306_00001163	SOS1	A0A2I0MXY9	A0A2I0LT24	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Uncharacterized protein.	0.515
A306_00001163	SYK	A0A2I0MXY9	A0A2I0M6D0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.804
A306_00001163	VAV1	A0A2I0MXY9	A0A2I0LI76	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Vav 1 guanine nucleotide exchange factor.	0.495
A306_00001163	VAV2	A0A2I0MXY9	A0A2I0M3R7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Vav 2 guanine nucleotide exchange factor.	0.495
A306_00001163	VAV3	A0A2I0MXY9	A0A2I0ME16	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Vav 3 guanine nucleotide exchange factor.	0.495
A306_00010002	LCP2	A0A2I0LXW3	A0A2I0M9Z1	Natural killer cells antigen CD94.	Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa).	0.491
A306_00010002	SYK	A0A2I0LXW3	A0A2I0M6D0	Natural killer cells antigen CD94.	Tyrosine-protein kinase.	0.536
A306_00010010	A306_00015346	A0A2I0LXZ4	A0A2I0LGH3	Killer cell lectin-like receptor subfamily G member 1.	Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family.	0.485
A306_00010010	B2M	A0A2I0LXZ4	A0A2I0LLQ4	Killer cell lectin-like receptor subfamily G member 1.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.448
A306_00015346	A306_00010010	A0A2I0LGH3	A0A2I0LXZ4	Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family.	Killer cell lectin-like receptor subfamily G member 1.	0.485
A306_00015346	B2M	A0A2I0LGH3	A0A2I0LLQ4	Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.991
B2M	A306_00010010	A0A2I0LLQ4	A0A2I0LXZ4	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin-like receptor subfamily G member 1.	0.448