(54 nodes) Semaphorin interactions network (Columba livia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A306_00000415	Uncharacterized protein. (288 aa)
	A306_00015368	Dihydropyrimidinase-related protein 5-like. (140 aa)
	A306_00000380	Uncharacterized protein. (242 aa)
	A306_00000329	Protein kinase domain-containing protein. (305 aa)
	A306_00015183	Rho guanine nucleotide exchange factor 12-like. (197 aa)
	SEMA6B	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6B; Belongs to the semaphorin family. (728 aa)
	LIMK1	Uncharacterized protein. (351 aa)
	A306_00014845	B-cell differentiation antigen CD72. (296 aa)
	A306_00014846	B-cell differentiation antigen CD72-like. (223 aa)
	A306_00000404	Uncharacterized protein. (281 aa)
	TLN1	FERM domain-containing protein. (488 aa)
	CDK5	Cyclin-dependent kinase 5. (196 aa)
	ARHGAP35	Rho GTPase activating protein 35. (630 aa)
	A306_00000382	Amidohydro-rel domain-containing protein. (194 aa)
	A306_00014449	Rho guanine nucleotide exchange factor 11. (1318 aa)
	SEMA6C	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6C. (468 aa)
	A306_00014369	Dual specificity testis-specific protein kinase 1. (283 aa)
	FARP2	FERM, RhoGEF and pleckstrin domain protein 2. (526 aa)
	PAK3	Non-specific serine/threonine protein kinase. (543 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12. (1149 aa)
	DPYSL3	Dihydropyrimidinase-like 3. (534 aa)
	DPYSL2	Dihydropyrimidinase-like 2. (536 aa)
	PLXND1	Plexin D1. (1535 aa)
	PAK2	Non-specific serine/threonine protein kinase. (525 aa)
	DSTN	Destrin (Actin depolymerizing factor), transcript variant X1; Belongs to the actin-binding proteins ADF family. (165 aa)
	PLXNA1	Plexin A1. (1877 aa)
	PLXNB1	Plexin B1. (2203 aa)
	RHOA	Ras homolog family member A. (193 aa)
	PLXNC1	Plexin C1, transcript variant X1. (1271 aa)
	PLXNA4	Plexin-A4. (1892 aa)
	LIMK2	LIM domain kinase 2. (588 aa)
	RHOC	Ras homolog family member C. (196 aa)
	PLXNA2	Plexin A2. (1345 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	SEMA7A	Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group), transcript variant X1; Belongs to the semaphorin family. (633 aa)
	TLN2	Talin 2. (1700 aa)
	SEMA6A	Semaphorin-6A isoform X2; Belongs to the semaphorin family. (1027 aa)
	HSP90AB1	Heat shock protein 90kDa alpha (Cytosolic), class B member 1. (94 aa)
	SEMA6D	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (Semaphorin) 6D. (1141 aa)
	PTPRC	Protein tyrosine phosphatase, receptor type, C, transcript variant X1. (1247 aa)
	DPYSL4	Dihydropyrimidinase-like 4. (586 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1382 aa)
	GSK3B	Glycogen synthase kinase 3 beta, transcript variant X1; Belongs to the protein kinase superfamily. (433 aa)
	CRMP1	Collapsin response mediator protein 1. (613 aa)
	CFL2	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (149 aa)
	HSP90AA1	Heat shock protein 90kDa alpha (Cytosolic), class A member 1. (728 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (855 aa)
	RHOB	Ras homolog family member B. (197 aa)
	ROCK2	Rho-associated, coiled-coil containing protein kinase 2, transcript variant X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1356 aa)
	PKHD1	Polycystic kidney and hepatic disease 1 (Autosomal recessive). (3788 aa)
	ROCK1	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1408 aa)
	DPYS	Dihydropyrimidinase. (507 aa)
	MESDC1	Mesoderm development candidate 1. (355 aa)
	PLXNB2	Plexin B2, transcript variant X1. (1841 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000329	CFL2	A0A2I0LGJ9	A0A2I0MNF3	Protein kinase domain-containing protein.	Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family.	0.659
A306_00000329	DSTN	A0A2I0LGJ9	A0A2I0LV82	Protein kinase domain-containing protein.	Destrin (Actin depolymerizing factor), transcript variant X1; Belongs to the actin-binding proteins ADF family.	0.659
A306_00000329	HSP90AA1	A0A2I0LGJ9	A0A2I0MNU1	Protein kinase domain-containing protein.	Heat shock protein 90kDa alpha (Cytosolic), class A member 1.	0.555
A306_00000329	HSP90AB1	A0A2I0LGJ9	A0A2I0MAK6	Protein kinase domain-containing protein.	Heat shock protein 90kDa alpha (Cytosolic), class B member 1.	0.555
A306_00000329	LIMK1	A0A2I0LGJ9	A0A2I0LHD0	Protein kinase domain-containing protein.	Uncharacterized protein.	0.900
A306_00000329	NRP1	A0A2I0LGJ9	A0A2I0MQZ2	Protein kinase domain-containing protein.	Neuropilin; Belongs to the neuropilin family.	0.405
A306_00000329	PAK1	A0A2I0LGJ9	A0A2I0M2P1	Protein kinase domain-containing protein.	Non-specific serine/threonine protein kinase.	0.519
A306_00000329	PAK2	A0A2I0LGJ9	A0A2I0LUS9	Protein kinase domain-containing protein.	Non-specific serine/threonine protein kinase.	0.522
A306_00000329	PAK3	A0A2I0LGJ9	A0A2I0LS69	Protein kinase domain-containing protein.	Non-specific serine/threonine protein kinase.	0.524
A306_00000380	A306_00000382	A0A2I0LGI4	A0A2I0LJD6	Uncharacterized protein.	Amidohydro-rel domain-containing protein.	0.951
A306_00000380	A306_00015368	A0A2I0LGI4	A0A2I0LGC2	Uncharacterized protein.	Dihydropyrimidinase-related protein 5-like.	0.951
A306_00000380	CDK5	A0A2I0LGI4	A0A2I0LI52	Uncharacterized protein.	Cyclin-dependent kinase 5.	0.451
A306_00000380	CRMP1	A0A2I0LGI4	A0A2I0MN08	Uncharacterized protein.	Collapsin response mediator protein 1.	0.425
A306_00000380	MET	A0A2I0LGI4	A0A2I0MJ90	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.436
A306_00000382	A306_00000380	A0A2I0LJD6	A0A2I0LGI4	Amidohydro-rel domain-containing protein.	Uncharacterized protein.	0.951
A306_00000382	A306_00015368	A0A2I0LJD6	A0A2I0LGC2	Amidohydro-rel domain-containing protein.	Dihydropyrimidinase-related protein 5-like.	0.951
A306_00000382	CDK5	A0A2I0LJD6	A0A2I0LI52	Amidohydro-rel domain-containing protein.	Cyclin-dependent kinase 5.	0.451
A306_00000382	MET	A0A2I0LJD6	A0A2I0MJ90	Amidohydro-rel domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.436
A306_00000415	FARP2	A0A2I0LGB5	A0A2I0LMF9	Uncharacterized protein.	FERM, RhoGEF and pleckstrin domain protein 2.	0.419
A306_00000415	MET	A0A2I0LGB5	A0A2I0MJ90	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.565