STRINGSTRING
SHC1 SHC1 FRS3 FRS3 FGF8 FGF8 FGF17 FGF17 FGF18 FGF18 SOS1 SOS1 FGF1 FGF1 CSDE1 CSDE1 NRAS NRAS A306_00006107 A306_00006107 GRB2 GRB2 PTPN11 PTPN11 FGF16 FGF16 PIK3CA PIK3CA FGF9 FGF9 FGF7 FGF7 FGFR2 FGFR2 FGF5 FGF5 GAB1 GAB1 HRAS HRAS FGF4 FGF4 FGF3 FGF3 FGF6 FGF6 KRAS KRAS FGF23 FGF23 FGF20 FGF20 FRS2 FRS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
FRS3Fibroblast growth factor receptor substrate 3. (469 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SOS1Uncharacterized protein. (1323 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (796 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
A306_00006107Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
GRB2Growth factor receptor-bound protein 2. (250 aa)
PTPN11Protein tyrosine phosphatase, non-receptor type 11. (587 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (123 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR2Fibroblast growth factor receptor. (843 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
GAB1GRB2-associated binding protein 1. (718 aa)
HRASUncharacterized protein. (189 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (157 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
KRASUncharacterized protein. (197 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (254 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (122 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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