39 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	A306_00000187	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (549 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (469 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	MKNK2	MAP kinase interacting serine/threonine kinase 2. (246 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	A306_00011441	Fibronectin type-III domain-containing protein 3a-like, transcript variant X1. (1189 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	SOS1	Uncharacterized protein. (1323 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase. (909 aa)
	MKNK1	MAP kinase interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (438 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (796 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	A306_00006107	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	GRB2	Growth factor receptor-bound protein 2. (250 aa)
	PTPN11	Protein tyrosine phosphatase, non-receptor type 11. (587 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	SPRED2	Sprouty-related, EVH1 domain containing 2. (409 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (649 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (313 aa)
	FNDC3A	Fibronectin type III domain containing 3A, transcript variant X1. (1199 aa)
	FLRT2	Fibronectin leucine rich transmembrane protein 2. (662 aa)
	SPRED1	Sprouty-related, EVH1 domain containing 1, transcript variant X1. (414 aa)
	FGFRL1	Fibroblast growth factor receptor-like 1. (525 aa)
	ANOS1	Anosmin 1. (437 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (254 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase, transcript variant X1. (754 aa)
	KRAS	Uncharacterized protein. (197 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (157 aa)
	HRAS	Uncharacterized protein. (189 aa)
	GAB1	GRB2-associated binding protein 1. (718 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	FNDC3B	Uncharacterized protein. (1154 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000187	A306_00006107	A0A2I0LH72	A0A2I0M3D4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.437
A306_00000187	ANOS1	A0A2I0LH72	A0A2I0MKY6	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Anosmin 1.	0.836
A306_00000187	CBL	A0A2I0LH72	A0A2I0LVE4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.426
A306_00000187	FGF1	A0A2I0LH72	A0A2I0LTA7	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.937
A306_00000187	FGF17	A0A2I0LH72	A0A2I0LR08	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.578
A306_00000187	FGF18	A0A2I0LH72	A0A2I0LSP8	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.710
A306_00000187	FGF23	A0A2I0LH72	A0A2I0MKG9	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.854
A306_00000187	FGF3	A0A2I0LH72	A0A2I0MI44	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.677
A306_00000187	FGF4	A0A2I0LH72	A0A2I0MI38	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.715
A306_00000187	FGF5	A0A2I0LH72	A0A2I0MH20	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.710
A306_00000187	FGF6	A0A2I0LH72	A0A2I0MKD0	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.670
A306_00000187	FGF8	A0A2I0LH72	A0A2I0LP43	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.869
A306_00000187	FGF9	A0A2I0LH72	A0A2I0MCY0	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.737
A306_00000187	FLRT2	A0A2I0LH72	A0A2I0MP77	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibronectin leucine rich transmembrane protein 2.	0.516
A306_00000187	FLRT3	A0A2I0LH72	A0A2I0M9J1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibronectin leucine rich transmembrane protein 3.	0.495
A306_00000187	FRS2	A0A2I0LH72	R7VVB2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor receptor substrate 2.	0.851
A306_00000187	FRS3	A0A2I0LH72	A0A2I0LMM4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor receptor substrate 3.	0.678
A306_00000187	GAB1	A0A2I0LH72	A0A2I0MH30	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GRB2-associated binding protein 1.	0.473
A306_00000187	GRB2	A0A2I0LH72	A0A2I0M7L1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Growth factor receptor-bound protein 2.	0.622
A306_00000187	PIK3CA	A0A2I0LH72	A0A2I0MBJ9	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.552