59 items (Columba livia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNAI1	Guanine nucleotide-binding protein G(I) subunit alpha-1. (302 aa)
	HRAS	Uncharacterized protein. (189 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (231 aa)
	KRAS	Uncharacterized protein. (197 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27, Kip1). (198 aa)
	GNB3	Guanine nucleotide binding protein (G protein), beta polypeptide 3. (340 aa)
	ESR2	Estrogen receptor 2 (ER beta). (451 aa)
	STRN3	Striatin, calmodulin binding protein 3, transcript variant X1. (681 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	A306_00002580	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
	WDR64	WD repeat domain 64. (1045 aa)
	FOXO3	Forkhead box O3. (535 aa)
	PTK2	Protein tyrosine kinase 2, transcript variant X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (757 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	SPHK1	Sphingosine kinase 1. (400 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
	GNB1	Guanine nucleotide binding protein (G protein), beta polypeptide 1. (340 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	MMP9	Matrix metallopeptidase 9. (734 aa)
	SRC	SRC proto-oncogene, non-receptor tyrosine kinase. (320 aa)
	HSPB1	Heat shock 27kDa protein 1; Belongs to the small heat shock protein (HSP20) family. (189 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
	ZDHHC7	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (305 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (796 aa)
	GNAI3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (343 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
	STRN	Striatin, calmodulin binding protein, transcript variant X2. (705 aa)
	PRMT8	Protein arginine methyltransferase 8, transcript variant X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (524 aa)
	GNG13	Guanine nucleotide binding protein (G protein), gamma 13. (67 aa)
	TGFA	Transforming growth factor, alpha. (154 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	ZDHHC3	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (327 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	BTC	Betacellulin. (213 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	GNAI2	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (303 aa)
	EGF	Epidermal growth factor. (1254 aa)
	XPO1	Exportin 1. (1059 aa)
	HBEGF	Heparin-binding EGF-like growth factor. (158 aa)
	GNB4	Guanine nucleotide binding protein (G protein), beta polypeptide 4. (340 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	A306_00007878	Collagenase 3. (472 aa)
	A306_00007880	Stromelysin-1. (478 aa)
	MMP7	Matrilysin. (263 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1332 aa)
	GNB5	Guanine nucleotide binding protein (G protein), beta 5. (388 aa)
	UHMK1	U2AF homology motif (UHM) kinase 1. (288 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (381 aa)
	ZDHHC21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	EREG	Epiregulin. (118 aa)
	EPGN	Epithelial mitogen. (151 aa)
	AREG	Amphiregulin. (312 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00002580	GNAI1	A0A2I0MQA5	A0A2I0MHJ3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I) subunit alpha-1.	0.705
A306_00002580	GNAI2	A0A2I0MQA5	A0A2I0LHY4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.705
A306_00002580	GNAI3	A0A2I0MQA5	A0A2I0LZU9	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.705
A306_00002580	GNB1	A0A2I0MQA5	A0A2I0M2Z5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.928
A306_00002580	GNB3	A0A2I0MQA5	A0A2I0MLQ6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta polypeptide 3.	0.888
A306_00002580	GNB4	A0A2I0MQA5	A0A2I0MBA5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta polypeptide 4.	0.928
A306_00002580	GNB5	A0A2I0MQA5	A0A2I0MDM8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), beta 5.	0.864
A306_00002580	GNG10	A0A2I0MQA5	R7VND5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.781
A306_00002580	GNG12	A0A2I0MQA5	A0A2I0MBU4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.643
A306_00002580	GNG13	A0A2I0MQA5	A0A2I0LTM3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide binding protein (G protein), gamma 13.	0.693
A306_00002580	GNG2	A0A2I0MQA5	A0A2I0MPW8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.663
A306_00002580	GNG4	A0A2I0MQA5	A0A2I0MTP2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.663
A306_00002580	GNGT2	A0A2I0MQA5	A0A2I0LSB6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.596
A306_00002580	HRAS	A0A2I0MQA5	A0A2I0MI00	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Uncharacterized protein.	0.676
A306_00002580	KRAS	A0A2I0MQA5	A0A2I0MKD5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Uncharacterized protein.	0.676
A306_00002580	NRAS	A0A2I0MQA5	A0A2I0LZZ9	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Neuroblastoma RAS viral (V-ras) oncogene homolog.	0.676
A306_00007878	A306_00007880	A0A2I0MCR2	A0A2I0MCS8	Collagenase 3.	Stromelysin-1.	0.548
A306_00007878	MMP2	A0A2I0MCR2	A0A2I0M2G1	Collagenase 3.	Matrix metallopeptidase 2.	0.532
A306_00007878	MMP7	A0A2I0MCR2	A0A2I0MCT1	Collagenase 3.	Matrilysin.	0.616
A306_00007878	MMP9	A0A2I0MCR2	A0A2I0M2C4	Collagenase 3.	Matrix metallopeptidase 9.	0.600