STRINGSTRING
ACOT8 ACOT8 PPARD PPARD PPARA PPARA SQLE SQLE LPIN2 LPIN2 KLF10 KLF10 ENPP2 ENPP2 NDRG1 NDRG1 CDH2 CDH2 SIRT5 SIRT5 FBXO9 FBXO9 LPIN1 LPIN1 FOXO3 FOXO3 ME1 ME1 GGPS1 GGPS1 ELOVL5 ELOVL5 ESR1 ESR1 BMP5 BMP5 APOB APOB FABP7 FABP7 A306_00000942 A306_00000942 KLF11 KLF11 KLF12 KLF12 FOXO1 FOXO1 ZBTB20 ZBTB20 PROZ PROZ INSIG1 INSIG1 RPL14 RPL14 KAT2B KAT2B MASTL MASTL PDK4 PDK4 KLF6 KLF6 HSD17B12 HSD17B12 GSTZ1 GSTZ1 ST3GAL5 ST3GAL5 PPARGC1A PPARGC1A KLF3 KLF3 ACSL1 ACSL1 RGN RGN PROS1 PROS1 VWF VWF ADIPOR2 ADIPOR2 FGF23 FGF23 FBLN1 FBLN1 AKR1D1 AKR1D1 SREBF2 SREBF2 GGA1 GGA1 A306_00005021 A306_00005021 TFPI TFPI CPT1A CPT1A LAMB1 LAMB1 EREG EREG NTRK2 NTRK2 CDK1 CDK1 HELLS HELLS SIRT1 SIRT1 GPAM GPAM HMGCS2 HMGCS2 ATF6 ATF6 DUT DUT PEX11A PEX11A PPAP2B PPAP2B ELOVL1 ELOVL1 SOAT1 SOAT1 MOGAT1 MOGAT1 ACOX2 ACOX2 SERTAD2 SERTAD2 ELOVL6 ELOVL6 MANBA MANBA STARD4 STARD4 AACS AACS COMT COMT RORA RORA LIPC LIPC KLF13 KLF13 PCK1 PCK1 GPX8 GPX8 ESRRG ESRRG IGFBP1 IGFBP1 EGFR EGFR GARNL3 GARNL3 AGPAT2 AGPAT2 SLC27A4 SLC27A4 MTOR MTOR TNFRSF1B TNFRSF1B E2F1 E2F1 HMGCR HMGCR PCF11 PCF11 LAMB3 LAMB3 NCOR1 NCOR1 ACACA ACACA CXCL12 CXCL12 FGA FGA IDH1 IDH1 IGFALS IGFALS PRL PRL MSMO1 MSMO1 MST1 MST1 ADIPOQ ADIPOQ SOX7 SOX7 SLC6A6 SLC6A6 KLF15 KLF15 FBLN2 FBLN2 PPARG PPARG SOX8 SOX8 EGR1 EGR1 PLIN2 PLIN2 MFSD2A MFSD2A E2F4 E2F4 LCAT LCAT CETP CETP KLF2 KLF2 NFYC NFYC COL1A1 COL1A1 FZD2 FZD2 BRCA1 BRCA1 FASN FASN PER3 PER3 FDPS FDPS RARA RARA NR1I3 NR1I3 HADHB HADHB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACOT8Uncharacterized protein. (218 aa)
PPARDPeroxisome proliferator-activated receptor delta, transcript variant X1. (443 aa)
PPARAPeroxisome proliferator-activated receptor alpha, transcript variant X1. (468 aa)
SQLESqualene epoxidase. (572 aa)
LPIN2Lipin 2. (920 aa)
KLF10Kruppel-like factor 10. (452 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2, transcript variant X1. (860 aa)
NDRG1N-myc downstream regulated 1. (402 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (878 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (465 aa)
FBXO9F-box protein 9, transcript variant X1. (404 aa)
LPIN1Lipin 1, transcript variant X2. (939 aa)
FOXO3Forkhead box O3. (535 aa)
ME1Malic enzyme 1, NADP(+)-dependent, cytosolic. (257 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (299 aa)
ELOVL5Elongation of very long chain fatty acids protein. (279 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
BMP5Bone morphogenetic protein 5. (453 aa)
APOBApolipoprotein B. (2608 aa)
FABP7Fatty acid binding protein 7, brain; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (120 aa)
A306_00000942Nuclear receptor subfamily 0 group B member 2. (271 aa)
KLF11Kruppel-like factor 11. (616 aa)
KLF12Kruppel-like factor 12, transcript variant X1. (396 aa)
FOXO1Forkhead box O1. (420 aa)
ZBTB20Zinc finger and BTB domain containing 20. (736 aa)
PROZProtein Z, vitamin K-dependent plasma glycoprotein; Belongs to the peptidase S1 family. (363 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (265 aa)
RPL14Ribosomal protein L14. (203 aa)
KAT2BK(Lysine) acetyltransferase 2B. (674 aa)
MASTLMicrotubule associated serine/threonine kinase-like. (983 aa)
PDK4Protein-serine/threonine kinase. (373 aa)
KLF6Kruppel-like factor 6. (283 aa)
HSD17B12Hydroxysteroid (17-beta) dehydrogenase 12, transcript variant X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (268 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (218 aa)
ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5, transcript variant X1; Belongs to the glycosyltransferase 29 family. (392 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (831 aa)
KLF3Kruppel-like factor 3 (Basic), transcript variant X1. (348 aa)
ACSL1Acyl-CoA synthetase long-chain family member 1. (698 aa)
RGNRegucalcin. (300 aa)
PROS1Protein S (Alpha). (619 aa)
VWFVon Willebrand factor. (2805 aa)
ADIPOR2Adiponectin receptor 2, transcript variant X1. (386 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (254 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (701 aa)
AKR1D1Aldo-keto reductase family 1, member D1. (204 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (448 aa)
GGA1Golgi-associated, gamma adaptin ear containing, ARF binding protein 1, transcript variant X1. (552 aa)
A306_00005021Prolactin. (189 aa)
TFPITissue factor pathway inhibitor isoform X1. (338 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver), transcript variant X1. (860 aa)
LAMB1Laminin, beta 1. (1718 aa)
EREGEpiregulin. (118 aa)
NTRK2Tyrosine-protein kinase receptor. (746 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
HELLSHelicase, lymphoid-specific. (1012 aa)
SIRT1Sirtuin 1, transcript variant X1. (606 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (796 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (403 aa)
ATF6Activating transcription factor 6. (477 aa)
DUTDeoxyuridine triphosphatase. (166 aa)
PEX11APeroxisomal biogenesis factor 11 alpha. (220 aa)
PPAP2BPhosphatidic acid phosphatase type 2B. (288 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (290 aa)
SOAT1O-acyltransferase. (549 aa)
MOGAT1Monoacylglycerol O-acyltransferase 1. (334 aa)
ACOX2Acyl-CoA oxidase 2, branched chain. (717 aa)
SERTAD2SERTA domain containing 2. (314 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (300 aa)
MANBAMannosidase, beta A, lysosomal, transcript variant X2. (811 aa)
STARD4StAR-related lipid transfer (START) domain containing 4. (172 aa)
AACSAcetoacetyl-CoA synthetase. (667 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (263 aa)
RORARAR-related orphan receptor A, transcript variant X1. (486 aa)
LIPCLipase, hepatic. (496 aa)
KLF13Kruppel-like factor 13. (273 aa)
PCK1Phosphoenolpyruvate carboxykinase 1 (Soluble). (669 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
ESRRGEstrogen-related receptor gamma. (435 aa)
IGFBP1Insulin-like growth factor binding protein 1. (231 aa)
EGFRReceptor protein-tyrosine kinase. (1164 aa)
GARNL3GTPase activating Rap/RanGAP domain-like 3. (981 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (248 aa)
SLC27A4Solute carrier family 27 (Fatty acid transporter), member 4. (650 aa)
MTORSerine/threonine-protein kinase TOR. (1875 aa)
TNFRSF1BTumor necrosis factor receptor superfamily, member 1B. (475 aa)
E2F1E2F transcription factor 1. (348 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
PCF11PCF11 cleavage and polyadenylation factor subunit. (1664 aa)
LAMB3Laminin, beta 3. (1144 aa)
NCOR1Nuclear receptor corepressor 1. (2480 aa)
ACACAAcetyl-CoA carboxylase alpha. (1676 aa)
CXCL12Chemokine (C-X-C motif) ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (147 aa)
FGAFibrinogen alpha chain. (766 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa)
IGFALSInsulin-like growth factor binding protein, acid labile subunit. (601 aa)
PRLProlactin. (229 aa)
MSMO1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (297 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. (482 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
SOX7SRY (Sex determining region Y)-box 7. (250 aa)
SLC6A6Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (687 aa)
KLF15Kruppel-like factor 15, transcript variant X1. (441 aa)
FBLN2Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (705 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
SOX8SRY (Sex determining region Y)-box 8. (445 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (480 aa)
PLIN2Perilipin; Belongs to the perilipin family. (446 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (435 aa)
E2F4E2F transcription factor 4, p107/p130-binding. (132 aa)
LCATLecithin-cholesterol acyltransferase. (454 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (499 aa)
KLF2Kruppel-like factor 2. (374 aa)
NFYCNuclear transcription factor Y, gamma. (465 aa)
COL1A1Collagen, type I, alpha 1. (1286 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (630 aa)
BRCA1Breast cancer 1, early onset. (1734 aa)
FASNFatty acid synthase. (2513 aa)
PER3Period circadian clock 3. (598 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (304 aa)
RARARetinoic acid receptor, alpha. (249 aa)
NR1I3Nuclear receptor subfamily 1, group I, member 3. (404 aa)
HADHBLOW QUALITY PROTEIN: trifunctional enzyme subunit beta, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (339 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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