64 items (Columba livia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A306_00014977	Signal transducer and activator of transcription 5B. (703 aa)
	RPS6KB2	Ribosomal protein S6 kinase, 70kDa, polypeptide 2; Belongs to the protein kinase superfamily. (234 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (128 aa)
	CAMK2B	Calcium/calmodulin-dependent protein kinase II beta. (334 aa)
	ERBB2	Receptor protein-tyrosine kinase. (929 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
	BTC	Betacellulin. (213 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4. (725 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	PAK3	Non-specific serine/threonine protein kinase. (543 aa)
	SOS2	Uncharacterized protein. (1183 aa)
	SOS1	Uncharacterized protein. (1323 aa)
	TGFA	Transforming growth factor, alpha. (154 aa)
	PAK2	Non-specific serine/threonine protein kinase. (525 aa)
	CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase. (909 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	PRKCB	Protein kinase C, beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (634 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
	CRKL	V-crk avian sarcoma virus CT10 oncogene homolog-like. (369 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1A (p21, Cip1). (150 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1245 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
	CRK	V-crk avian sarcoma virus CT10 oncogene homolog. (306 aa)
	PLCG1	Phosphoinositide phospholipase C. (1215 aa)
	SRC	SRC proto-oncogene, non-receptor tyrosine kinase. (320 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	MTOR	Serine/threonine-protein kinase TOR. (1875 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase. (448 aa)
	EGFR	Receptor protein-tyrosine kinase. (1164 aa)
	NRG1	Neuregulin 1, transcript variant X1. (685 aa)
	NRG4	Neuregulin 4, transcript variant X1. (116 aa)
	PRKCA	Protein kinase C, alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (615 aa)
	GRB2	Growth factor receptor-bound protein 2. (250 aa)
	MAPK1	Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
	EGF	Epidermal growth factor. (1254 aa)
	PAK7	Non-specific serine/threonine protein kinase. (720 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase II alpha, transcript variant X1; Belongs to the protein kinase superfamily. (489 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	JUN	Jun proto-oncogene; Belongs to the bZIP family. (338 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	SHC4	SHC (Src homology 2 domain containing) family, member 4. (621 aa)
	NRG3	Neuregulin 3. (377 aa)
	CAMK2G	Calcium/calmodulin-dependent protein kinase II gamma. (510 aa)
	SHC3	SHC (Src homology 2 domain containing) transforming protein 3. (632 aa)
	AREG	Amphiregulin. (312 aa)
	MAPK10	Mitogen-activated protein kinase. (484 aa)
	GAB1	GRB2-associated binding protein 1. (718 aa)
	HRAS	Uncharacterized protein. (189 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1323 aa)
	KRAS	Uncharacterized protein. (197 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B (p27, Kip1). (198 aa)
	GSK3B	Glycogen synthase kinase 3 beta, transcript variant X1; Belongs to the protein kinase superfamily. (433 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	A306_00003000	E3 ubiquitin-protein ligase CBL-B. (733 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PTK2	Protein tyrosine kinase 2, transcript variant X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (757 aa)
	A306_00001163	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1300 aa)
	PAK6	Non-specific serine/threonine protein kinase. (667 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00001163	A306_00003000	A0A2I0MXY9	A0A2I0MSW8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	E3 ubiquitin-protein ligase CBL-B.	0.430
A306_00001163	AKT3	A0A2I0MXY9	A0A2I0MTK2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.424
A306_00001163	BTC	A0A2I0MXY9	A0A2I0LMD4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Betacellulin.	0.421
A306_00001163	CAMK2A	A0A2I0MXY9	A0A2I0M9X4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Calcium/calmodulin-dependent protein kinase II alpha, transcript variant X1; Belongs to the protein kinase superfamily.	0.901
A306_00001163	CAMK2B	A0A2I0MXY9	A0A2I0LJN9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Calcium/calmodulin-dependent protein kinase II beta.	0.901
A306_00001163	CAMK2G	A0A2I0MXY9	A0A2I0MFJ8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Calcium/calmodulin-dependent protein kinase II gamma.	0.901
A306_00001163	CBL	A0A2I0MXY9	A0A2I0LVE4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.430
A306_00001163	EGF	A0A2I0MXY9	A0A2I0M930	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Epidermal growth factor.	0.453
A306_00001163	EGFR	A0A2I0MXY9	A0A2I0M4T2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Receptor protein-tyrosine kinase.	0.955
A306_00001163	ERBB2	A0A2I0MXY9	A0A2I0LL36	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Receptor protein-tyrosine kinase.	0.955
A306_00001163	ERBB4	A0A2I0MXY9	A0A2I0MIN8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Receptor protein-tyrosine kinase.	0.955
A306_00001163	GRB2	A0A2I0MXY9	A0A2I0M7L1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Growth factor receptor-bound protein 2.	0.850
A306_00001163	NCK2	A0A2I0MXY9	A0A2I0MSQ7	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Cytoplasmic protein.	0.401
A306_00001163	PAK2	A0A2I0MXY9	A0A2I0LUS9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Non-specific serine/threonine protein kinase.	0.443
A306_00001163	PIK3CA	A0A2I0MXY9	A0A2I0MBJ9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.741
A306_00001163	PIK3CB	A0A2I0MXY9	A0A2I0LW23	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.741
A306_00001163	PIK3CD	A0A2I0MXY9	A0A2I0M316	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.741
A306_00001163	PIK3R1	A0A2I0MXY9	A0A2I0M199	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1.	0.729
A306_00001163	PIK3R2	A0A2I0MXY9	A0A2I0LQ03	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta).	0.729
A306_00001163	PIK3R3	A0A2I0MXY9	A0A2I0LYZ1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1.	0.729