STRINGSTRING
CCNB3 CCNB3 IKBKB IKBKB STK11 STK11 STAT3 STAT3 PRKAG3 PRKAG3 GADD45B GADD45B A306_00014013 A306_00014013 G6PC G6PC PLK3 PLK3 INSR INSR KLF2 KLF2 MAP2K2 MAP2K2 S1PR4 S1PR4 HOMER3 HOMER3 PIK3R2 PIK3R2 CCNG2 CCNG2 SKP2 SKP2 IL7R IL7R SMAD4 SMAD4 A306_00012651 A306_00012651 SOS2 SOS2 SOS1 SOS1 PRKAA1 PRKAA1 BCL6 BCL6 PIK3CB PIK3CB PDPK1 PDPK1 PLK1 PLK1 CHUK CHUK PTEN PTEN MAPK8 MAPK8 NLK NLK PIK3R3 PIK3R3 PRKAB1 PRKAB1 CDKN1A CDKN1A IL10 IL10 NRAS NRAS PIK3R1 PIK3R1 HOMER1 HOMER1 STK4 STK4 SGK2 SGK2 GABARAPL2 GABARAPL2 RBL2 RBL2 PIK3CD PIK3CD USP7 USP7 CREBBP CREBBP FOXO4 FOXO4 EGFR EGFR TGFBR1 TGFBR1 TGFB2 TGFB2 PLK2 PLK2 PCK1 PCK1 CCNB2 CCNB2 GRB2 GRB2 MAPK1 MAPK1 ATG12 ATG12 EGF EGF MAPK9 MAPK9 A306_00007560 A306_00007560 PIK3CA PIK3CA IRS1 IRS1 PRKAB2 PRKAB2 PRKAA2 PRKAA2 FASLG FASLG ATM ATM HOMER2 HOMER2 IGF1R IGF1R MAP2K1 MAP2K1 SMAD3 SMAD3 S1PR1 S1PR1 BNIP3 BNIP3 SIRT1 SIRT1 GADD45G GADD45G A306_00006656 A306_00006656 MAPK10 MAPK10 SETD7 SETD7 PLK4 PLK4 MAPK12 MAPK12 A306_00007180 A306_00007180 INS INS CAT CAT HRAS HRAS CCND1 CCND1 G6PC2 G6PC2 EP300 EP300 CSNK1E CSNK1E IGF1 IGF1 KRAS KRAS CDKN1B CDKN1B CCND2 CCND2 MDM2 MDM2 FOXG1 FOXG1 RAG1 RAG1 RAG2 RAG2 TGFB3 TGFB3 IL6 IL6 PRKAG2 PRKAG2 TGFBR2 TGFBR2 FOXO1 FOXO1 AKT3 AKT3 SGK1 SGK1 FBXO25 FBXO25 GRM1 GRM1 SOD2 SOD2 FOXO3 FOXO3 FBXO32 FBXO32 A306_00001428 A306_00001428 GABARAPL1 GABARAPL1 A306_00014012 A306_00014012
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNB3Cyclin B3; Belongs to the cyclin family. (405 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (453 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
PRKAG3Protein kinase, AMP-activated, gamma 3 non-catalytic subunit, transcript variant X1. (534 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (111 aa)
A306_00014013Mitogen-activated protein kinase. (182 aa)
G6PCGlucose-6-phosphatase, catalytic subunit. (358 aa)
PLK3Polo-like kinase 3. (582 aa)
INSRTyrosine-protein kinase receptor. (1345 aa)
KLF2Kruppel-like factor 2. (374 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
S1PR4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (405 aa)
HOMER3Homer scaffolding protein 3. (353 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (338 aa)
SKP2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (370 aa)
IL7RInterleukin 7 receptor. (462 aa)
SMAD4Mothers against decapentaplegic homolog. (470 aa)
A306_00012651Forkhead box protein O3-like. (443 aa)
SOS2Uncharacterized protein. (1183 aa)
SOS1Uncharacterized protein. (1323 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
BCL6B-cell CLL/lymphoma 6. (709 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (524 aa)
PLK1Polo-like kinase 1. (418 aa)
CHUKConserved helix-loop-helix ubiquitous kinase. (681 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (505 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit, transcript variant X1. (286 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1). (150 aa)
IL10Interleukin 10. (176 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
HOMER1Homer scaffolding protein 1. (356 aa)
STK4Serine/threonine kinase 4. (452 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
GABARAPL2GABA(A) receptor-associated protein like 2. (122 aa)
RBL2Retinoblastoma-like 2. (952 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
USP7Ubiquitin specific peptidase 7 (Herpes virus-associated); Belongs to the peptidase C19 family. (1055 aa)
CREBBPCREB binding protein. (2195 aa)
FOXO4Forkhead box O4. (380 aa)
EGFRReceptor protein-tyrosine kinase. (1164 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PLK2Polo-like kinase 2, transcript variant X2. (517 aa)
PCK1Phosphoenolpyruvate carboxykinase 1 (Soluble). (669 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (400 aa)
GRB2Growth factor receptor-bound protein 2. (250 aa)
MAPK1Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (160 aa)
EGFEpidermal growth factor. (1254 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
A306_00007560Insulin receptor substrate 2-B-like. (1035 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
IRS1Insulin receptor substrate 1. (557 aa)
PRKAB2AMPK1_CBM domain-containing protein. (180 aa)
PRKAA2Non-specific serine/threonine protein kinase. (480 aa)
FASLGFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (295 aa)
ATMNon-specific serine/threonine protein kinase. (3056 aa)
HOMER2Homer scaffolding protein 2. (411 aa)
IGF1RTyrosine-protein kinase receptor. (1332 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
SMAD3Mothers against decapentaplegic homolog. (321 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3. (202 aa)
SIRT1Sirtuin 1, transcript variant X1. (606 aa)
GADD45GGrowth arrest and DNA-damage-inducible, gamma. (110 aa)
A306_00006656TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
MAPK10Mitogen-activated protein kinase. (484 aa)
SETD7SET domain containing (Lysine methyltransferase) 7. (462 aa)
PLK4Polo-like kinase 4. (1027 aa)
MAPK12Mitogen-activated protein kinase. (352 aa)
A306_00007180Mitogen-activated protein kinase. (221 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
HRASUncharacterized protein. (189 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
EP300E1A binding protein p300. (2044 aa)
CSNK1ECasein kinase I isoform epsilon; Belongs to the protein kinase superfamily. (429 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C), transcript variant X1. (153 aa)
KRASUncharacterized protein. (197 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (p27, Kip1). (198 aa)
CCND2Cyclin D2; Belongs to the cyclin family. (285 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
FOXG1Forkhead box G1. (348 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1034 aa)
RAG2Recombination activating protein 2. (535 aa)
TGFB3Transforming growth factor, beta 3. (456 aa)
IL6Interleukin 6. (150 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (305 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (633 aa)
FOXO1Forkhead box O1. (420 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SGK1Non-specific serine/threonine protein kinase. (517 aa)
FBXO25F-box protein 25, transcript variant X1. (370 aa)
GRM1Glutamate receptor, metabotropic 1, transcript variant X1. (1187 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
FOXO3Forkhead box O3. (535 aa)
FBXO32F-box protein 32. (370 aa)
A306_00001428Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
A306_00014012Mitogen-activated protein kinase. (365 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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