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EIF4E1B EIF4E1B CASTOR1 CASTOR1 WNT6 WNT6 NPRL2 NPRL2 WDR24 WDR24 ATP6V1B1 ATP6V1B1 A306_00014861 A306_00014861 WNT10A WNT10A RPS6KB2 RPS6KB2 EIF4EBP1 EIF4EBP1 IKBKB IKBKB STK11 STK11 LAMTOR2 LAMTOR2 TTI1 TTI1 LAMTOR1 LAMTOR1 WNT1 WNT1 RPS6KA1 RPS6KA1 EIF4B EIF4B FZD9 FZD9 STRADA STRADA RPTOR RPTOR FZD2 FZD2 WNT9B WNT9B INSR INSR MAP2K2 MAP2K2 PIK3R2 PIK3R2 STRADB STRADB FZD7 FZD7 SLC7A5 SLC7A5 WNT4 WNT4 SKP2 SKP2 A306_00012717 A306_00012717 RPS6 RPS6 RRAGC RRAGC SOS2 SOS2 SOS1 SOS1 TSC2 TSC2 RICTOR RICTOR PRKAA1 PRKAA1 FNIP2 FNIP2 WNT7A WNT7A SEC13 SEC13 FZD3 FZD3 CAB39 CAB39 PIK3CB PIK3CB RHOA RHOA ATP6V1G1 ATP6V1G1 TELO2 TELO2 PRKCB PRKCB PDPK1 PDPK1 MLST8 MLST8 CHUK CHUK PTEN PTEN FZD5 FZD5 WNT8B WNT8B RPS6KB1 RPS6KB1 ULK2 ULK2 PIK3R3 PIK3R3 DEPDC5 DEPDC5 WNT2B WNT2B NRAS NRAS WDR59 WDR59 FLCN FLCN FZD4 FZD4 PIK3R1 PIK3R1 EIF4E2 EIF4E2 CASTOR2 CASTOR2 WNT11 WNT11 MTOR MTOR PIK3CD PIK3CD DVL1 DVL1 TSC1 TSC1 MAPKAP1 MAPKAP1 NPRL3 NPRL3 SLC38A9 SLC38A9 A306_00008277 A306_00008277 PRKCA PRKCA GRB2 GRB2 ULK1 ULK1 MAPK1 MAPK1 FZD10 FZD10 CLIP1 CLIP1 EIF4E EIF4E LAMTOR3 LAMTOR3 WNT5A WNT5A WNT8A WNT8A FNIP1 FNIP1 RPS6KA6 RPS6KA6 A306_00007612 A306_00007612 PIK3CA PIK3CA IRS1 IRS1 PRKAA2 PRKAA2 IGF1R IGF1R MAP2K1 MAP2K1 ATP6V1G3 ATP6V1G3 INS INS HRAS HRAS LRP5 LRP5 WNT16 WNT16 IGF1 IGF1 WNT7B WNT7B KRAS KRAS WNT5B WNT5B LRP6 LRP6 PRR5 PRR5 ATP6V1E1 ATP6V1E1 TNFRSF1A TNFRSF1A A306_00003658 A306_00003658 GSK3B GSK3B ATP6V1A ATP6V1A RPS6KA3 RPS6KA3 ATP6V1D ATP6V1D MIOS MIOS WNT3A WNT3A WNT9A WNT9A CAB39L CAB39L ATP6V1C2 ATP6V1C2 AKT3 AKT3 RPS6KA2 RPS6KA2 RRAGD RRAGD SGK1 SGK1 LPIN1 LPIN1 DEPTOR DEPTOR FZD6 FZD6 ATP6V1C1 ATP6V1C1 LPIN2 LPIN2 SEH1L SEH1L ATP6V1H ATP6V1H RNF152 RNF152 GRB10 GRB10 TBC1D7 TBC1D7 WNT3 WNT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (206 aa)
CASTOR1ACT_7 domain-containing protein. (213 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (301 aa)
NPRL2NPR2-like, GATOR1 complex subunit. (375 aa)
WDR24WD repeat domain 24. (789 aa)
ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1. (239 aa)
A306_00014861V-type proton ATPase catalytic subunit A-like. (393 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
RPS6KB2Ribosomal protein S6 kinase, 70kDa, polypeptide 2; Belongs to the protein kinase superfamily. (234 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (128 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (453 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (170 aa)
TTI1TELO2 interacting protein 1. (972 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (147 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (414 aa)
RPS6KA1Ribosomal protein S6 kinase, 90kDa, polypeptide 1. (773 aa)
EIF4BEukaryotic translation initiation factor 4B. (368 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
STRADASTE20-related kinase adaptor alpha, transcript variant X1. (373 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1345 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (630 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
INSRTyrosine-protein kinase receptor. (1345 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
STRADBSTE20-related kinase adaptor beta, transcript variant X1. (426 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (516 aa)
SLC7A5Solute carrier family 7 (Amino acid transporter light chain, L system), member 5. (512 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SKP2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (370 aa)
A306_00012717Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (297 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (274 aa)
RRAGCRas-related GTP binding C. (315 aa)
SOS2Uncharacterized protein. (1183 aa)
SOS1Uncharacterized protein. (1323 aa)
TSC2Tuberous sclerosis 2. (1142 aa)
RICTORRPTOR independent companion of MTOR, complex 2. (1676 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
FNIP2Folliculin interacting protein 2, transcript variant X1. (1155 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (306 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CAB39Calcium binding protein 39. (341 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
RHOARas homolog family member A. (193 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (98 aa)
TELO2Telomere maintenance 2, transcript variant X1. (723 aa)
PRKCBProtein kinase C, beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (634 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (524 aa)
MLST8MTOR associated protein, LST8 homolog. (271 aa)
CHUKConserved helix-loop-helix ubiquitous kinase. (681 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (611 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1077 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
DEPDC5DEP domain containing 5, transcript variant X1. (1595 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
WDR59WD repeat domain 59. (1003 aa)
FLCNFolliculin. (579 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (433 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (233 aa)
CASTOR2GATS-like protein 1. (326 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MTORSerine/threonine-protein kinase TOR. (1875 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
DVL1Dishevelled segment polarity protein 1. (561 aa)
TSC1Tuberous sclerosis 1, transcript variant X1. (1157 aa)
MAPKAP1Mitogen-activated protein kinase associated protein 1. (486 aa)
NPRL3NPR3-like, GATOR1 complex subunit, transcript variant X1. (537 aa)
SLC38A9Solute carrier family 38, member 9. (542 aa)
A306_00008277DEP domain-containing mTOR-interacting protein. (440 aa)
PRKCAProtein kinase C, alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (615 aa)
GRB2Growth factor receptor-bound protein 2. (250 aa)
ULK1Unc-51 like autophagy activating kinase 1, transcript variant X1. (984 aa)
MAPK1Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (541 aa)
CLIP1CAP-GLY domain containing linker protein 1. (1337 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (134 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
FNIP1Folliculin interacting protein 1, transcript variant X1. (1144 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (714 aa)
A306_00007612Ras-related GTP-binding protein A. (313 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
IRS1Insulin receptor substrate 1. (557 aa)
PRKAA2Non-specific serine/threonine protein kinase. (480 aa)
IGF1RTyrosine-protein kinase receptor. (1332 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
HRASUncharacterized protein. (189 aa)
LRP5Low density lipoprotein receptor-related protein 5, transcript variant X2. (1591 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (193 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C), transcript variant X1. (153 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
KRASUncharacterized protein. (197 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
LRP6Low density lipoprotein receptor-related protein 6. (1586 aa)
PRR5Proline rich 5 (Renal). (335 aa)
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1, transcript variant X1. (226 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (394 aa)
A306_00003658Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
GSK3BGlycogen synthase kinase 3 beta, transcript variant X1; Belongs to the protein kinase superfamily. (433 aa)
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A. (617 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (707 aa)
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D. (229 aa)
MIOSZinc_ribbon_16 domain-containing protein. (877 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (377 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (316 aa)
CAB39LCalcium binding protein 39-like, transcript variant X1. (334 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
RRAGDRas-related GTP binding D. (333 aa)
SGK1Non-specific serine/threonine protein kinase. (517 aa)
LPIN1Lipin 1, transcript variant X2. (939 aa)
DEPTORDEP domain containing MTOR-interacting protein, transcript variant X1. (412 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (670 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
LPIN2Lipin 2. (920 aa)
SEH1LSEH1-like nucleoporin; Belongs to the WD repeat SEC13 family. (325 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
RNF152Ring finger protein 152. (199 aa)
GRB10Growth factor receptor-bound protein 10. (590 aa)
TBC1D7TBC1 domain family, member 7. (293 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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