STRINGSTRING
A306_00015346 A306_00015346 CCNB3 CCNB3 PPP1CA PPP1CA RAD9A RAD9A PPP3CC PPP3CC EIF4EBP1 EIF4EBP1 VDAC3 VDAC3 GADD45B GADD45B A306_00014013 A306_00014013 CCND3 CCND3 RBL1 RBL1 RBBP4 RBBP4 ITPR3 ITPR3 E2F2 E2F2 BTRC BTRC CDC25A CDC25A MAP2K2 MAP2K2 PIK3R2 PIK3R2 RAD1 RAD1 CHEK1 CHEK1 FBXW11 FBXW11 NFATC1 NFATC1 RAD50 RAD50 TSC2 TSC2 PPID PPID ETS1 ETS1 MRE11A MRE11A GATA4 GATA4 PIK3CB PIK3CB E2F3 E2F3 PTEN PTEN A306_00011314 A306_00011314 FOXM1 FOXM1 PIK3R3 PIK3R3 HIPK1 HIPK1 CDKN1A CDKN1A RASSF5 RASSF5 MAPKAPK2 MAPKAPK2 NRAS NRAS SMAD2 SMAD2 MAP2K3 MAP2K3 PIK3R1 PIK3R1 E2F1 E2F1 MYBL2 MYBL2 RBL2 RBL2 MTOR MTOR PIK3CD PIK3CD TSC1 TSC1 IGFBP3 IGFBP3 HUS1 HUS1 TGFBR1 TGFBR1 CAPN2 CAPN2 TGFB2 TGFB2 LIN9 LIN9 NFATC2 NFATC2 CCNB2 CCNB2 MAP2K6 MAP2K6 CCNE1 CCNE1 NFATC3 NFATC3 MAPK1 MAPK1 PPP1CC PPP1CC TRPV4 TRPV4 CHEK2 CHEK2 RAD9B RAD9B NFKB1 NFKB1 PPP3CA PPP3CA PPP3R1 PPP3R1 CACNA1D CACNA1D ITPR1 ITPR1 VDAC1 VDAC1 SQSTM1 SQSTM1 PPP1CB PPP1CB A306_00008766 A306_00008766 SLC25A5 SLC25A5 ATR ATR PIK3CA PIK3CA ATM ATM CCNA1 CCNA1 MAP2K1 MAP2K1 SMAD3 SMAD3 TRPM7 TRPM7 CALML4 CALML4 SIRT1 SIRT1 PPP3CB PPP3CB VDAC2 VDAC2 CDK1 CDK1 GADD45G GADD45G A306_00006656 A306_00006656 MRAS MRAS CCNA2 CCNA2 LIN54 LIN54 IL-8 IL-8 CXCL8-3 CXCL8-3 MAPK12 MAPK12 A306_00007180 A306_00007180 HIPK3 HIPK3 HRAS HRAS CCND1 CCND1 RRAS2 RRAS2 HIPK2 HIPK2 ITPR2 ITPR2 KRAS KRAS CCND2 CCND2 MDM2 MDM2 SLC25A6 SLC25A6 SLC25A4 SLC25A4 ZFP36L1 ZFP36L1 TGFB3 TGFB3 IL6 IL6 CDK6 CDK6 TGFBR2 TGFBR2 RB1 RB1 FOXO1 FOXO1 AKT3 AKT3 TRAF3IP2 TRAF3IP2 FOXO3 FOXO3 CCNE2 CCNE2 E2F5 E2F5 NBN NBN A306_00014012 A306_00014012
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A306_00015346Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family. (177 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (405 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
RAD9ARAD9 checkpoint clamp component A. (300 aa)
PPP3CCSerine/threonine-protein phosphatase. (504 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (128 aa)
VDAC3Voltage-dependent anion channel 3, transcript variant X1. (297 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (111 aa)
A306_00014013Mitogen-activated protein kinase. (182 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (280 aa)
RBL1Retinoblastoma-like 1. (977 aa)
RBBP4Retinoblastoma binding protein 4. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor, type 3. (2664 aa)
E2F2E2F transcription factor 2. (368 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase, transcript variant X1. (633 aa)
CDC25ACell division cycle 25A. (459 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
RAD1RAD1 checkpoint DNA exonuclease. (265 aa)
CHEK1Checkpoint kinase 1. (310 aa)
FBXW11F-box and WD repeat domain containing 11, transcript variant X3. (531 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, transcript variant X1. (811 aa)
RAD50RAD50 homolog, double strand break repair protein. (1312 aa)
TSC2Tuberous sclerosis 2. (1142 aa)
PPIDPeptidylprolyl isomerase D. (382 aa)
ETS1V-ets avian erythroblastosis virus E26 oncogene homolog 1. (271 aa)
MRE11AMRE11 homolog A, double strand break repair nuclease; Belongs to the MRE11/RAD32 family. (743 aa)
GATA4GATA binding protein 4. (219 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
E2F3E2F transcription factor 3, transcript variant X1. (337 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
A306_00011314Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
FOXM1Forkhead box M1. (673 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
HIPK1Homeodomain interacting protein kinase 1, transcript variant X2. (1207 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1). (150 aa)
RASSF5Ras association (RalGDS/AF-6) domain family member 5. (279 aa)
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2. (309 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (348 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
E2F1E2F transcription factor 1. (348 aa)
MYBL2V-myb avian myeloblastosis viral oncogene homolog-like 2. (676 aa)
RBL2Retinoblastoma-like 2. (952 aa)
MTORSerine/threonine-protein kinase TOR. (1875 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
TSC1Tuberous sclerosis 1, transcript variant X1. (1157 aa)
IGFBP3Insulin-like growth factor binding protein 3. (183 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CAPN2Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. (693 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LIN9Lin-9 DREAM MuvB core complex component, transcript variant X1. (491 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. (507 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (400 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (316 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (407 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (999 aa)
MAPK1Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
TRPV4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (863 aa)
CHEK2Checkpoint kinase 2, transcript variant X1. (522 aa)
RAD9BRAD9 checkpoint clamp component B. (392 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (959 aa)
PPP3CASerine/threonine-protein phosphatase. (460 aa)
PPP3R1Protein phosphatase 3, regulatory subunit B, alpha. (160 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor, type 1. (1897 aa)
VDAC1Voltage-dependent anion channel 1. (283 aa)
SQSTM1Sequestosome 1, transcript variant X1. (398 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
A306_00008766Calmodulin; Belongs to the calmodulin family. (149 aa)
SLC25A5Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (271 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2780 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
ATMNon-specific serine/threonine protein kinase. (3056 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (469 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
SMAD3Mothers against decapentaplegic homolog. (321 aa)
TRPM7Transient receptor potential cation channel, subfamily M, member 7. (1875 aa)
CALML4Calmodulin-like 4. (153 aa)
SIRT1Sirtuin 1, transcript variant X1. (606 aa)
PPP3CBSerine/threonine-protein phosphatase. (439 aa)
VDAC2Voltage-dependent anion channel 2. (283 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
GADD45GGrowth arrest and DNA-damage-inducible, gamma. (110 aa)
A306_00006656TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
MRASMuscle RAS oncogene homolog, transcript variant X1. (208 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (288 aa)
LIN54Lin-54 DREAM MuvB core complex component, transcript variant X1. (805 aa)
IL-8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
CXCL8-3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (156 aa)
MAPK12Mitogen-activated protein kinase. (352 aa)
A306_00007180Mitogen-activated protein kinase. (221 aa)
HIPK3Homeodomain interacting protein kinase 3, transcript variant X1. (1193 aa)
HRASUncharacterized protein. (189 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
RRAS2Uncharacterized protein. (275 aa)
HIPK2Homeodomain interacting protein kinase 2. (872 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2638 aa)
KRASUncharacterized protein. (197 aa)
CCND2Cyclin D2; Belongs to the cyclin family. (285 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
SLC25A6Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (281 aa)
SLC25A4Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (278 aa)
ZFP36L1ZFP36 ring finger protein-like 1. (203 aa)
TGFB3Transforming growth factor, beta 3. (456 aa)
IL6Interleukin 6. (150 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (633 aa)
RB1Retinoblastoma 1. (901 aa)
FOXO1Forkhead box O1. (420 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRAF3IP2TRAF3 interacting protein 2. (540 aa)
FOXO3Forkhead box O3. (535 aa)
CCNE2Cyclin E2, transcript variant X3; Belongs to the cyclin family. (403 aa)
E2F5E2F transcription factor 5, p130-binding. (335 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (766 aa)
A306_00014012Mitogen-activated protein kinase. (365 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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