74 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CC	Serine/threonine-protein phosphatase. (504 aa)
	IKBKB	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
	A306_00014013	Mitogen-activated protein kinase. (182 aa)
	MALT1	MALT1 paracaspase. (474 aa)
	A306_00012971	Hepatic lectin, transcript variant X1. (217 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor, type 3. (2664 aa)
	A306_00013357	Caspase-1; Belongs to the peptidase C14A family. (394 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (601 aa)
	A306_00013655	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like. (514 aa)
	PLK3	Polo-like kinase 3. (582 aa)
	CCL17	C-C motif chemokine. (94 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	A306_00011847	Caspase-8, transcript variant X2; Belongs to the peptidase C14A family. (464 aa)
	A306_00011848	Caspase-8, transcript variant X1; Belongs to the peptidase C14A family. (455 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (571 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12. (1149 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, transcript variant X1. (811 aa)
	IRF1	Interferon regulatory factor. (312 aa)
	EGR3	Early growth response 3. (341 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	RHOA	Ras homolog family member A. (193 aa)
	CHUK	Conserved helix-loop-helix ubiquitous kinase. (681 aa)
	A306_00011314	Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	KSR1	Kinase suppressor of ras 1. (534 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
	IL10	Interleukin 10. (176 aa)
	MAPKAPK2	Mitogen-activated protein kinase-activated protein kinase 2. (309 aa)
	NRAS	Neuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
	IKBKE	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (722 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1245 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
	SRC	SRC proto-oncogene, non-receptor tyrosine kinase. (320 aa)
	CYLD	Cylindromatosis (Turban tumor syndrome); Belongs to the peptidase C19 family. (949 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	A306_00006107	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	CARD9	Caspase recruitment domain family, member 9. (541 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. (507 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (999 aa)
	MAPK1	Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
	PTPN11	Protein tyrosine phosphatase, non-receptor type 11. (587 aa)
	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (959 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (460 aa)
	PPP3R1	Protein phosphatase 3, regulatory subunit B, alpha. (160 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor, type 1. (1897 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	A306_00008766	Calmodulin; Belongs to the calmodulin family. (149 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	JUN	Jun proto-oncogene; Belongs to the bZIP family. (338 aa)
	CALML4	Calmodulin-like 4. (153 aa)
	BCL10	B-cell CLL/lymphoma 10. (214 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (439 aa)
	MRAS	Muscle RAS oncogene homolog, transcript variant X1. (208 aa)
	A306_00007027	Interleukin; Belongs to the IL-15/IL-21 family. (137 aa)
	MAPK10	Mitogen-activated protein kinase. (484 aa)
	MAPK12	Mitogen-activated protein kinase. (352 aa)
	A306_00007180	Mitogen-activated protein kinase. (221 aa)
	LSP1	Lymphocyte-specific protein 1, transcript variant X1. (362 aa)
	HRAS	Uncharacterized protein. (189 aa)
	RRAS2	Uncharacterized protein. (275 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor, type 2. (2638 aa)
	KRAS	Uncharacterized protein. (197 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (484 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (333 aa)
	IL6	Interleukin 6. (150 aa)
	A306_00003000	E3 ubiquitin-protein ligase CBL-B. (733 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	A306_00001162	Ubiquitin carboxyl-terminal hydrolase CYLD. (823 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (269 aa)
	A306_00014012	Mitogen-activated protein kinase. (365 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00001162	A306_00011847	A0A2I0MXZ0	A0A2I0LQ88	Ubiquitin carboxyl-terminal hydrolase CYLD.	Caspase-8, transcript variant X2; Belongs to the peptidase C14A family.	0.914
A306_00001162	A306_00011848	A0A2I0MXZ0	A0A2I0LQ91	Ubiquitin carboxyl-terminal hydrolase CYLD.	Caspase-8, transcript variant X1; Belongs to the peptidase C14A family.	0.914
A306_00001162	CHUK	A0A2I0MXZ0	A0A2I0LX57	Ubiquitin carboxyl-terminal hydrolase CYLD.	Conserved helix-loop-helix ubiquitous kinase.	0.712
A306_00001162	CYLD	A0A2I0MXZ0	A0A2I0M2H6	Ubiquitin carboxyl-terminal hydrolase CYLD.	Cylindromatosis (Turban tumor syndrome); Belongs to the peptidase C19 family.	0.903
A306_00001162	IKBKB	A0A2I0MXZ0	A0A2I0LJJ4	Ubiquitin carboxyl-terminal hydrolase CYLD.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.676
A306_00001162	IKBKE	A0A2I0MXZ0	A0A2I0M078	Ubiquitin carboxyl-terminal hydrolase CYLD.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.	0.958
A306_00001162	LSP1	A0A2I0MXZ0	A0A2I0MHW6	Ubiquitin carboxyl-terminal hydrolase CYLD.	Lymphocyte-specific protein 1, transcript variant X1.	0.906
A306_00003000	A306_00006107	A0A2I0MSW8	A0A2I0M3D4	E3 ubiquitin-protein ligase CBL-B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.545
A306_00003000	AKT3	A0A2I0MSW8	A0A2I0MTK2	E3 ubiquitin-protein ligase CBL-B.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.420
A306_00003000	IL6	A0A2I0MSW8	A0A2I0MQA2	E3 ubiquitin-protein ligase CBL-B.	Interleukin 6.	0.464
A306_00003000	PIK3CA	A0A2I0MSW8	A0A2I0MBJ9	E3 ubiquitin-protein ligase CBL-B.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.518
A306_00003000	PIK3CB	A0A2I0MSW8	A0A2I0LW23	E3 ubiquitin-protein ligase CBL-B.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.518
A306_00003000	PIK3CD	A0A2I0MSW8	A0A2I0M316	E3 ubiquitin-protein ligase CBL-B.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.493
A306_00003000	PIK3R1	A0A2I0MSW8	A0A2I0M199	E3 ubiquitin-protein ligase CBL-B.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1.	0.680
A306_00003000	PIK3R2	A0A2I0MSW8	A0A2I0LQ03	E3 ubiquitin-protein ligase CBL-B.	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta).	0.680
A306_00003000	PIK3R3	A0A2I0MSW8	A0A2I0LYZ1	E3 ubiquitin-protein ligase CBL-B.	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1.	0.680
A306_00003000	PLCG2	A0A2I0MSW8	A0A2I0M0A9	E3 ubiquitin-protein ligase CBL-B.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.452
A306_00003000	PTPN11	A0A2I0MSW8	A0A2I0M8A8	E3 ubiquitin-protein ligase CBL-B.	Protein tyrosine phosphatase, non-receptor type 11.	0.545
A306_00003000	SRC	A0A2I0MSW8	A0A2I0M2A8	E3 ubiquitin-protein ligase CBL-B.	SRC proto-oncogene, non-receptor tyrosine kinase.	0.670
A306_00006107	A306_00003000	A0A2I0M3D4	A0A2I0MSW8	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	E3 ubiquitin-protein ligase CBL-B.	0.545