STRINGSTRING
EIF4E1B EIF4E1B A306_00000181 A306_00000181 PPP1CA PPP1CA RPS6KB2 RPS6KB2 EIF4EBP1 EIF4EBP1 IKBKB IKBKB INPPL1 INPPL1 HK3 HK3 PRKAG3 PRKAG3 FLOT2 FLOT2 A306_00013635 A306_00013635 SHC1 SHC1 PHKA1 PHKA1 FASN FASN A306_00013982 A306_00013982 G6PC G6PC RPTOR RPTOR MKNK2 MKNK2 INSR INSR MAP2K2 MAP2K2 PIK3R2 PIK3R2 RPS6 RPS6 SOS2 SOS2 PYGL PYGL SOS1 SOS1 TSC2 TSC2 PRKAA1 PRKAA1 PYGB PYGB CBL CBL PIK3CB PIK3CB SOCS2 SOCS2 PDPK1 PDPK1 A306_00011314 A306_00011314 PPP1R3B PPP1R3B MAPK8 MAPK8 PPP1R3C PPP1R3C ACACA ACACA RPS6KB1 RPS6KB1 MKNK1 MKNK1 PIK3R3 PIK3R3 PRKAB1 PRKAB1 CRKL CRKL NRAS NRAS PRKAR1B PRKAR1B PIK3R1 PIK3R1 EIF4E2 EIF4E2 PHKG1 PHKG1 CRK CRK SH2B2 SH2B2 PHKB PHKB MTOR MTOR PIK3CD PIK3CD PRKCZ PRKCZ RAPGEF1 RAPGEF1 TSC1 TSC1 SOCS1 SOCS1 PTPN1 PTPN1 PCK1 PCK1 PPP1R3D PPP1R3D PRKAR1A PRKAR1A EXOC7 EXOC7 GRB2 GRB2 MAPK1 MAPK1 PPP1CC PPP1CC ACACB ACACB EIF4E EIF4E PRKAR2A PRKAR2A MAPK9 MAPK9 PPP1CB PPP1CB A306_00008766 A306_00008766 RHOQ RHOQ A306_00007560 A306_00007560 PRKCI PRKCI PIK3CA PIK3CA IRS1 IRS1 PRKAB2 PRKAB2 PTPRF PTPRF PRKAA2 PRKAA2 MAP2K1 MAP2K1 CALML4 CALML4 SHC4 SHC4 PRKACB PRKACB INPP5A INPP5A A306_00005227 A306_00005227 A306_00005228 A306_00005228 SHC3 SHC3 FBP1 FBP1 A306_00007979 A306_00007979 MAPK10 MAPK10 PRKAR2B PRKAR2B INS INS HRAS HRAS PDE3B PDE3B G6PC2 G6PC2 PPP1R3A PPP1R3A KRAS KRAS GYS2 GYS2 PHKA2 PHKA2 GSK3B GSK3B PPARGC1A PPARGC1A PRKAG2 PRKAG2 A306_00003000 A306_00003000 FOXO1 FOXO1 AKT3 AKT3 SOCS4 SOCS4 SOCS3 SOCS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (206 aa)
A306_00000181IPPc domain-containing protein. (633 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
RPS6KB2Ribosomal protein S6 kinase, 70kDa, polypeptide 2; Belongs to the protein kinase superfamily. (234 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (128 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (665 aa)
HK3Hexokinase 3 (White cell). (967 aa)
PRKAG3Protein kinase, AMP-activated, gamma 3 non-catalytic subunit, transcript variant X1. (534 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
A306_00013635Protein phosphatase 1 regulatory subunit. (355 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (345 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1186 aa)
FASNFatty acid synthase. (2513 aa)
A306_00013982Hexokinase-2-like. (925 aa)
G6PCGlucose-6-phosphatase, catalytic subunit. (358 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1345 aa)
MKNK2MAP kinase interacting serine/threonine kinase 2. (246 aa)
INSRTyrosine-protein kinase receptor. (1345 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (274 aa)
SOS2Uncharacterized protein. (1183 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (891 aa)
SOS1Uncharacterized protein. (1323 aa)
TSC2Tuberous sclerosis 2. (1142 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (815 aa)
CBLCbl proto-oncogene, E3 ubiquitin protein ligase. (909 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
SOCS2Suppressor of cytokine signaling 2. (143 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (524 aa)
A306_00011314Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (286 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (314 aa)
ACACAAcetyl-CoA carboxylase alpha. (1676 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
MKNK1MAP kinase interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (438 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
PRKAB1Protein kinase, AMP-activated, beta 1 non-catalytic subunit, transcript variant X1. (286 aa)
CRKLV-crk avian sarcoma virus CT10 oncogene homolog-like. (369 aa)
NRASNeuroblastoma RAS viral (V-ras) oncogene homolog. (123 aa)
PRKAR1BProtein kinase, cAMP-dependent, regulatory, type I, beta. (381 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (233 aa)
PHKG1Phosphorylase kinase, gamma 1 (Muscle); Belongs to the protein kinase superfamily. (388 aa)
CRKV-crk avian sarcoma virus CT10 oncogene homolog. (306 aa)
SH2B2SH2B adaptor protein 2. (629 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1081 aa)
MTORSerine/threonine-protein kinase TOR. (1875 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 1. (1032 aa)
TSC1Tuberous sclerosis 1, transcript variant X1. (1157 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (354 aa)
PCK1Phosphoenolpyruvate carboxykinase 1 (Soluble). (669 aa)
PPP1R3DProtein phosphatase 1, regulatory subunit 3D. (307 aa)
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha, transcript variant X1. (382 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (701 aa)
GRB2Growth factor receptor-bound protein 2. (250 aa)
MAPK1Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
ACACBAcetyl-CoA carboxylase beta. (1345 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
PRKAR2AProtein kinase, cAMP-dependent, regulatory, type II, alpha. (378 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
A306_00008766Calmodulin; Belongs to the calmodulin family. (149 aa)
RHOQRas homolog family member Q. (126 aa)
A306_00007560Insulin receptor substrate 2-B-like. (1035 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (540 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
IRS1Insulin receptor substrate 1. (557 aa)
PRKAB2AMPK1_CBM domain-containing protein. (180 aa)
PTPRFProtein tyrosine phosphatase, receptor type, F. (1901 aa)
PRKAA2Non-specific serine/threonine protein kinase. (480 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
CALML4Calmodulin-like 4. (153 aa)
SHC4SHC (Src homology 2 domain containing) family, member 4. (621 aa)
PRKACBProtein kinase, cAMP-dependent, catalytic, beta, transcript variant X1; Belongs to the protein kinase superfamily. (398 aa)
INPP5AInositol polyphosphate-5-phosphatase, 40kDa. (364 aa)
A306_00005227Putative hexokinase HKDC1, transcript variant X1. (952 aa)
A306_00005228Hexokinase-1. (917 aa)
SHC3SHC (Src homology 2 domain containing) transforming protein 3. (632 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (403 aa)
A306_00007979Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (340 aa)
MAPK10Mitogen-activated protein kinase. (484 aa)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, beta. (324 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
HRASUncharacterized protein. (189 aa)
PDE3BPhosphodiesterase. (762 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PPP1R3AProtein phosphatase 1, regulatory subunit 3A. (1160 aa)
KRASUncharacterized protein. (197 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1163 aa)
GSK3BGlycogen synthase kinase 3 beta, transcript variant X1; Belongs to the protein kinase superfamily. (433 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (831 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (305 aa)
A306_00003000E3 ubiquitin-protein ligase CBL-B. (733 aa)
FOXO1Forkhead box O1. (420 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SOCS4Suppressor of cytokine signaling 4. (436 aa)
SOCS3Suppressor of cytokine signaling 3. (209 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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