STRINGSTRING
TRAF6 TRAF6 ARPC2 ARPC2 A306_00015090 A306_00015090 A306_00014690 A306_00014690 CYTH1 CYTH1 IKBKB IKBKB TCF7L1 TCF7L1 VPS11 VPS11 RAB5B RAB5B A306_00014013 A306_00014013 RAB5C RAB5C DYNLRB1 DYNLRB1 FHOD1 FHOD1 A306_00013357 A306_00013357 BAK1 BAK1 MYL9 MYL9 MAP2K4 MAP2K4 RHOG RHOG MAP2K2 MAP2K2 A306_00011847 A306_00011847 A306_00011848 A306_00011848 CD14 CD14 CDC42 CDC42 IL18 IL18 CTNNB1 CTNNB1 PAK3 PAK3 ARF6 ARF6 VPS41 VPS41 RALA RALA FLNB FLNB EXOC5 EXOC5 KLC4 KLC4 TIRAP TIRAP RAB7A RAB7A PIK3CB PIK3CB RHOA RHOA TLR4 TLR4 CYFIP2 CYFIP2 CHUK CHUK PODXL PODXL EXOC4 EXOC4 TLR2 TLR2 A306_00011065 A306_00011065 M6PR M6PR MAPK8 MAPK8 NLRC4 NLRC4 DYNLL2 DYNLL2 DYNLL1 DYNLL1 ELMO1 ELMO1 PIK3C2B PIK3C2B RAB7B RAB7B TRADD TRADD DYNLRB2 DYNLRB2 A306_00009652 A306_00009652 MLKL MLKL PIK3C3 PIK3C3 ACTB ACTB ARPC1A ARPC1A RAC1 RAC1 CYTH3 CYTH3 ARPC1B ARPC1B MAP2K3 MAP2K3 KPNA4 KPNA4 PFN2 PFN2 ARHGEF26 ARHGEF26 RILP RILP MYL10 MYL10 CSE1L CSE1L ELMO2 ELMO2 PAK1 PAK1 RPS3 RPS3 PIK3CD PIK3CD PLEKHM2 PLEKHM2 RAB9B RAB9B PFN3 PFN3 TLR5 TLR5 ACBD3 ACBD3 SNX18 SNX18 NAIP NAIP A306_00009924 A306_00009924 DYNLT3 DYNLT3 TAB3 TAB3 FBXO22 FBXO22 ANXA2 ANXA2 SNX33 SNX33 MAP2K6 MAP2K6 EXOC7 EXOC7 DYNC1LI2 DYNC1LI2 MAPK1 MAPK1 A306_00005367 A306_00005367 A306_00005366 A306_00005366 ARPC3 ARPC3 NFKB1 NFKB1 LEF1 LEF1 MAPK9 MAPK9 SKP1 SKP1 TCF7 TCF7 DYNC2LI1 DYNC2LI1 A306_00007517 A306_00007517 A306_00007518 A306_00007518 A306_00007489 A306_00007489 A306_00007595 A306_00007595 PIK3CA PIK3CA JUN JUN WASF3 WASF3 DYNC2H1 DYNC2H1 BIRC2 BIRC2 MAP2K1 MAP2K1 PTPRC PTPRC TCF7L2 TCF7L2 CASP7 CASP7 IL-8 IL-8 MAPK10 MAPK10 CXCL8-3 CXCL8-3 MAPK12 MAPK12 PIK3CG PIK3CG A306_00007180 A306_00007180 PIK3C2A PIK3C2A A306_00004635 A306_00004635 HRAS HRAS FADD FADD NCKAP1 NCKAP1 DYNC1I2 DYNC1I2 WASL WASL TXN2 TXN2 IRAK4 IRAK4 TAB1 TAB1 CYTH4 CYTH4 HSP90B1 HSP90B1 TNFRSF1A TNFRSF1A KPNA1 KPNA1 CYFIP1 CYFIP1 GAPDH GAPDH RHOH RHOH CASP3 CASP3 KLC1 KLC1 NFKBIA NFKBIA VPS39 VPS39 FOS FOS DYNC1H1 DYNC1H1 HSP90AA1 HSP90AA1 RHOJ RHOJ VPS18 VPS18 A306_00002661 A306_00002661 IL6 IL6 A306_00002381 A306_00002381 DYNC1LI1 DYNC1LI1 MYD88 MYD88 FYCO1 FYCO1 DYNC1I1 DYNC1I1 RAB5A RAB5A GCC2 GCC2 KPNA3 KPNA3 A306_00003167 A306_00003167 AKT3 AKT3 SNX9 SNX9 MYO6 MYO6 PFN4 PFN4 TAB2 TAB2 RHOB RHOB ROCK2 ROCK2 BCL2 BCL2 LY96 LY96 A306_00001583 A306_00001583 MYL12B MYL12B EXOC2 EXOC2 RIPK1 RIPK1 RIPK2 RIPK2 RAB9A RAB9A NOD1 NOD1 S100A10 S100A10 IL1B IL1B A306_00014012 A306_00014012
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (277 aa)
A306_00015090Neuroblast differentiation-associated protein AHNAK-like. (4222 aa)
A306_00014690Nck-associated protein 1-like. (983 aa)
CYTH1Uncharacterized protein. (359 aa)
IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
TCF7L1Transcription factor 7-like 1 (T-cell specific, HMG-box). (364 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
RAB5BRAB5B, member RAS oncogene family. (250 aa)
A306_00014013Mitogen-activated protein kinase. (182 aa)
RAB5CRAB5C, member RAS oncogene family. (216 aa)
DYNLRB1Dynein light chain roadblock. (96 aa)
FHOD1Uncharacterized protein. (916 aa)
A306_00013357Caspase-1; Belongs to the peptidase C14A family. (394 aa)
BAK1BCL2-antagonist/killer 1. (217 aa)
MYL9Uncharacterized protein. (141 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (725 aa)
RHOGRas homolog family member G. (236 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
A306_00011847Caspase-8, transcript variant X2; Belongs to the peptidase C14A family. (464 aa)
A306_00011848Caspase-8, transcript variant X1; Belongs to the peptidase C14A family. (455 aa)
CD14CD14 molecule. (416 aa)
CDC42Cell division cycle 42, transcript variant X2. (191 aa)
IL18Interleukin-18. (196 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (814 aa)
PAK3Non-specific serine/threonine protein kinase. (543 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (216 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
RALAV-ral simian leukemia viral oncogene homolog A (Ras related), transcript variant X1. (206 aa)
FLNBFilamin B, beta. (2642 aa)
EXOC5Exocyst complex component 5, transcript variant X1. (719 aa)
KLC4Kinesin light chain 4. (633 aa)
TIRAPToll-interleukin 1 receptor (TIR) domain containing adaptor protein, transcript variant X1. (207 aa)
RAB7ARAB7A, member RAS oncogene family, transcript variant X1. (207 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
RHOARas homolog family member A. (193 aa)
TLR4Toll-like receptor 4. (779 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
CHUKConserved helix-loop-helix ubiquitous kinase. (681 aa)
PODXLPodocalyxin-like. (568 aa)
EXOC4Exocyst complex component 4. (976 aa)
TLR2Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family. (517 aa)
A306_00011065Toll-like receptor 2 type-1, transcript variant X1; Belongs to the Toll-like receptor family. (793 aa)
M6PRMannose-6-phosphate receptor (Cation dependent). (278 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NLRC4NLR family, CARD domain containing 4. (1031 aa)
DYNLL2Dynein light chain. (96 aa)
DYNLL1Dynein light chain. (89 aa)
ELMO1Engulfment and cell motility 1, transcript variant X1. (727 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (806 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
TRADDTNFRSF1A-associated via death domain. (306 aa)
DYNLRB2Dynein, light chain, roadblock-type 2. (76 aa)
A306_00009652Receptor-interacting serine/threonine-protein kinase 2. (541 aa)
MLKLMixed lineage kinase domain-like. (485 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (844 aa)
ACTBActin, beta. (375 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (179 aa)
CYTH3Cytohesin 3. (399 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (348 aa)
KPNA4Importin subunit alpha; Belongs to the importin alpha family. (497 aa)
PFN2Profilin; Belongs to the profilin family. (245 aa)
ARHGEF26Rho guanine nucleotide exchange factor (GEF) 26. (797 aa)
RILPRab interacting lysosomal protein. (353 aa)
MYL10Myosin, light chain 10, regulatory. (165 aa)
CSE1LImportin N-terminal domain-containing protein. (971 aa)
ELMO2Engulfment and cell motility 2. (733 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
PLEKHM2Pleckstrin homology domain containing, family M (With RUN domain) member 2. (777 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
PFN3Profilin; Belongs to the profilin family. (134 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (860 aa)
ACBD3Acyl-CoA binding domain containing 3. (434 aa)
SNX18Sorting nexin 18. (397 aa)
NAIPNLR family, apoptosis inhibitory protein. (1432 aa)
A306_00009924Thioredoxin. (159 aa)
DYNLT3Dynein, light chain, Tctex-type 3. (116 aa)
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 3, transcript variant X1. (680 aa)
FBXO22F-box protein 22. (314 aa)
ANXA2Annexin. (326 aa)
SNX33Sorting nexin. (563 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (316 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (701 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (535 aa)
MAPK1Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
A306_00005367Myosin regulatory light chain 2A, cardiac muscle isoform. (146 aa)
A306_00005366Myosin regulatory light chain 2A, cardiac muscle isoform. (193 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (959 aa)
LEF1Lymphoid enhancer-binding factor 1. (360 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SKP1S-phase kinase-associated protein 1, transcript variant X1; Belongs to the SKP1 family. (163 aa)
TCF7Transcription factor 7 (T-cell specific, HMG-box), transcript variant X1. (340 aa)
DYNC2LI1Dynein, cytoplasmic 2, light intermediate chain 1. (252 aa)
A306_00007517Dynein light chain. (89 aa)
A306_00007518Dynein light chain. (77 aa)
A306_00007489Rho-related GTP-binding protein RhoG, transcript variant X1. (191 aa)
A306_00007595Wiskott-Aldrich syndrome protein family member 3-like. (414 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
JUNJun proto-oncogene; Belongs to the bZIP family. (338 aa)
WASF3WAS protein family, member 3. (410 aa)
DYNC2H1Dynein, cytoplasmic 2, heavy chain 1. (3352 aa)
BIRC2Baculoviral IAP repeat containing 2. (611 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
PTPRCProtein tyrosine phosphatase, receptor type, C, transcript variant X1. (1247 aa)
TCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box). (224 aa)
CASP7Caspase 7, apoptosis-related cysteine peptidase, transcript variant X1; Belongs to the peptidase C14A family. (309 aa)
IL-8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
MAPK10Mitogen-activated protein kinase. (484 aa)
CXCL8-3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (156 aa)
MAPK12Mitogen-activated protein kinase. (352 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
A306_00007180Mitogen-activated protein kinase. (221 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1699 aa)
A306_00004635Putative LOC102095613. (416 aa)
HRASUncharacterized protein. (189 aa)
FADDFas (TNFRSF6)-associated via death domain. (195 aa)
NCKAP1NCK-associated protein 1. (1028 aa)
DYNC1I2Dynein, cytoplasmic 1, intermediate chain 2, transcript variant X3. (629 aa)
WASLWiskott-Aldrich syndrome-like, transcript variant X1. (456 aa)
TXN2Thioredoxin 2, transcript variant X1. (203 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 1. (498 aa)
CYTH4Cytohesin 4. (406 aa)
HSP90B1Heat shock protein 90kDa beta (Grp94), member 1. (876 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (394 aa)
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (327 aa)
RHOHRas homolog family member H. (191 aa)
CASP3Caspase 3, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (282 aa)
KLC1Kinesin light chain 1, transcript variant X1. (637 aa)
NFKBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (333 aa)
VPS39CNH domain-containing protein. (861 aa)
FOSFBJ murine osteosarcoma viral oncogene homolog. (158 aa)
DYNC1H1Dynein, cytoplasmic 1, heavy chain 1. (1927 aa)
HSP90AA1Heat shock protein 90kDa alpha (Cytosolic), class A member 1. (728 aa)
RHOJRas homolog family member J. (214 aa)
VPS18Pep3_Vps18 domain-containing protein. (974 aa)
A306_00002661Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IL6Interleukin 6. (150 aa)
A306_00002381ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (171 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (496 aa)
MYD88Myeloid differentiation primary response 88. (152 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1382 aa)
DYNC1I1Dynein, cytoplasmic 1, intermediate chain 1. (611 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
GCC2GRIP and coiled-coil domain containing 2, transcript variant X1. (1690 aa)
KPNA3Importin subunit alpha; Belongs to the importin alpha family. (497 aa)
A306_00003167Cytohesin-2-like. (64 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SNX9Sorting nexin. (599 aa)
MYO6Myosin VI, transcript variant X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
PFN4Uncharacterized protein; Belongs to the profilin family. (108 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (688 aa)
RHOBRas homolog family member B. (197 aa)
ROCK2Rho-associated, coiled-coil containing protein kinase 2, transcript variant X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1356 aa)
BCL2B-cell CLL/lymphoma 2. (138 aa)
LY96Lymphocyte antigen 96. (122 aa)
A306_00001583Myosin regulatory light chain 2, smooth muscle minor isoform. (225 aa)
MYL12BMyosin regulatory light chain 2, smooth muscle minor isoform. (172 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (685 aa)
RIPK2Receptor-interacting serine-threonine kinase 2. (547 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (951 aa)
S100A10S100 calcium binding protein A10. (58 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (269 aa)
A306_00014012Mitogen-activated protein kinase. (365 aa)
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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