106 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A306_00015345	Trypsin. (177 aa)
	A306_00015228	Class II histocompatibility antigen, B-L beta chain. (228 aa)
	DNAJB1	DnaJ homolog subfamily B member 1. (237 aa)
	A306_00015350	HLA class II histocompatibility antigen, DM beta chain-like. (106 aa)
	A306_00015196	HLA class II histocompatibility antigen, DR alpha chain. (151 aa)
	TMPRSS4	Transmembrane protease, serine 4; Belongs to the peptidase S1 family. (499 aa)
	ADAR	Adenosine deaminase, RNA-specific. (650 aa)
	PABPN1L	Poly(A) binding protein, nuclear 1-like (Cytoplasmic). (243 aa)
	IKBKB	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
	A306_00014228	Ras-related protein Rab-11A-like. (235 aa)
	RAB11B	RAB11B, member RAS oncogene family. (158 aa)
	FDPS	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (304 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (280 aa)
	KPNA6	Importin subunit alpha; Belongs to the importin alpha family. (553 aa)
	A306_00013357	Caspase-1; Belongs to the peptidase C14A family. (394 aa)
	BAK1	BCL2-antagonist/killer 1. (217 aa)
	NUP98	Nucleoporin 98kDa. (1990 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (403 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	A306_00011847	Caspase-8, transcript variant X2; Belongs to the peptidase C14A family. (464 aa)
	A306_00011848	Caspase-8, transcript variant X1; Belongs to the peptidase C14A family. (455 aa)
	TICAM1	Toll-like receptor adaptor molecule 1. (610 aa)
	IL18	Interleukin-18. (196 aa)
	A306_00013079	Interferon alpha-2. (197 aa)
	NXT2	Nuclear transport factor 2-like export factor 2. (113 aa)
	CALCOCO2	Calcium binding and coiled-coil domain 2. (414 aa)
	A306_00010988	E3 ubiquitin/ISG15 ligase TRIM25, transcript variant X1. (410 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	NLRX1	NLR family member X1. (602 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	TLR4	Toll-like receptor 4. (779 aa)
	PRKCB	Protein kinase C, beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (634 aa)
	CHUK	Conserved helix-loop-helix ubiquitous kinase. (681 aa)
	FAS	Fas cell surface death receptor. (399 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2-alpha kinase 2. (609 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
	IKBKE	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (722 aa)
	TRADD	TNFRSF1A-associated via death domain. (306 aa)
	ACTB	Actin, beta. (375 aa)
	KPNA7	Importin subunit alpha; Belongs to the importin alpha family. (516 aa)
	CPSF4	Cleavage and polyadenylation specific factor 4, 30kDa. (190 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	CASP9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (409 aa)
	CIITA	Class II, major histocompatibility complex, transactivator. (533 aa)
	CREBBP	CREB binding protein. (2195 aa)
	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (730 aa)
	RAE1	Ribonucleic acid export 1, transcript variant X1. (413 aa)
	A306_00006775	Protein PML. (586 aa)
	A306_00006777	Protein PML. (739 aa)
	KPNA2	Karyopherin alpha 2 (RAG cohort 1, importin alpha 1). (440 aa)
	PRKCA	Protein kinase C, alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (615 aa)
	TRIM25	E3 ubiquitin/ISG15 ligase TRIM25. (550 aa)
	MAPK1	Mitogen-activated protein kinase 1, transcript variant X2. (263 aa)
	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (959 aa)
	XPO1	Exportin 1. (1059 aa)
	VDAC1	Voltage-dependent anion channel 1. (283 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	SLC25A5	Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (271 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	RNASEL	Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). (701 aa)
	JAK1	Tyrosine-protein kinase. (699 aa)
	FASLG	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (295 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	RAB11A	RAB11A, member RAS oncogene family. (206 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	IL-8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	CXCL8-3	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (156 aa)
	A306_00004635	Putative LOC102095613. (416 aa)
	FADD	Fas (TNFRSF6)-associated via death domain. (195 aa)
	IRF7	Interferon regulatory factor 7. (530 aa)
	IFIH1	Interferon induced with helicase C domain 1. (981 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	EP300	E1A binding protein p300. (2044 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (191 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (394 aa)
	KPNA1	Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1047 aa)
	SLC25A6	Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (281 aa)
	SLC25A4	Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (278 aa)
	MAVS	Mitochondrial antiviral signaling protein. (632 aa)
	CASP3	Caspase 3, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (282 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (895 aa)
	EIF2S1	Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa. (315 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (333 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	A306_00002661	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	IL6	Interleukin 6. (150 aa)
	MYD88	Myeloid differentiation primary response 88. (152 aa)
	CDK6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3. (462 aa)
	IFNGR2	Interferon gamma receptor 2 (Interferon gamma transducer 1). (319 aa)
	IFNAR2	Interferon (Alpha, beta and omega) receptor 2, transcript variant X2. (502 aa)
	IFNAR1	Interferon (Alpha, beta and omega) receptor 1. (631 aa)
	A306_00002783	Interferon-induced GTP-binding protein Mx-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (648 aa)
	TMPRSS2	Transmembrane protease, serine 2; Belongs to the peptidase S1 family. (484 aa)
	IFNGR1	Interferon gamma receptor 1. (410 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	A306_00000619	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (802 aa)
	A306_00000618	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (817 aa)
	KPNA5	Importin subunit alpha; Belongs to the importin alpha family. (536 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (269 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00000618	A306_00000619	A0A2I0MV53	A0A2I0MV52	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.901
A306_00000619	A306_00000618	A0A2I0MV52	A0A2I0MV53	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.901
A306_00002661	A306_00011847	A0A2I0MQ77	A0A2I0LQ88	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase-8, transcript variant X2; Belongs to the peptidase C14A family.	0.700
A306_00002661	A306_00011848	A0A2I0MQ77	A0A2I0LQ91	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase-8, transcript variant X1; Belongs to the peptidase C14A family.	0.764
A306_00002661	A306_00013357	A0A2I0MQ77	A0A2I0LNL9	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase-1; Belongs to the peptidase C14A family.	0.439
A306_00002661	AKT3	A0A2I0MQ77	A0A2I0MTK2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.476
A306_00002661	APAF1	A0A2I0MQ77	A0A2I0LUL5	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.999
A306_00002661	BAK1	A0A2I0MQ77	A0A2I0LNN2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	BCL2-antagonist/killer 1.	0.976
A306_00002661	CASP3	A0A2I0MQ77	A0A2I0MMP4	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase 3, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.889
A306_00002661	CASP9	A0A2I0MQ77	A0A2I0M343	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.998
A306_00002661	FADD	A0A2I0MQ77	A0A2I0MI45	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Fas (TNFRSF6)-associated via death domain.	0.482
A306_00002661	FASLG	A0A2I0MQ77	A0A2I0MCI4	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	0.491
A306_00002661	IFNGR2	A0A2I0MQ77	A0A2I0MSG2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Interferon gamma receptor 2 (Interferon gamma transducer 1).	0.488
A306_00002661	IL6	A0A2I0MQ77	A0A2I0MQA2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Interleukin 6.	0.458
A306_00002661	MAPK1	A0A2I0MQ77	A0A2I0M868	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Mitogen-activated protein kinase 1, transcript variant X2.	0.465
A306_00002661	SLC25A4	A0A2I0MQ77	A0A2I0MM38	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.508
A306_00002661	SLC25A5	A0A2I0MQ77	A0A2I0MAU8	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.508
A306_00002661	SLC25A6	A0A2I0MQ77	A0A2I0MLL6	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.508
A306_00002661	VDAC1	A0A2I0MQ77	A0A2I0MA37	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Voltage-dependent anion channel 1.	0.611
A306_00002783	A306_00013357	A0A2I0MSP6	A0A2I0LNL9	Interferon-induced GTP-binding protein Mx-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caspase-1; Belongs to the peptidase C14A family.	0.454