111 items (Columba livia) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	A306_00015228	Class II histocompatibility antigen, B-L beta chain. (228 aa)
	A306_00015346	Class I histocompatibility antigen, F10 alpha chain; Belongs to the MHC class I family. (177 aa)
	A306_00015350	HLA class II histocompatibility antigen, DM beta chain-like. (106 aa)
	A306_00015196	HLA class II histocompatibility antigen, DR alpha chain. (151 aa)
	A306_00014920	Zinc finger protein 585A. (900 aa)
	A306_00014919	Gastrula zinc finger protein XlCGF26.1-like, transcript variant X1. (748 aa)
	A306_00014722	Zinc finger protein 777-like. (653 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (128 aa)
	IKBKB	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (743 aa)
	A306_00014486	Gastrula zinc finger protein XlCGF57.1-like, transcript variant X2. (583 aa)
	A306_00014135	Gastrula zinc finger protein XlCGF57.1-like, transcript variant X1. (564 aa)
	A306_00014143	Gastrula zinc finger protein XlCGF7.1. (324 aa)
	SRPK1	SRSF protein kinase 1; Belongs to the protein kinase superfamily. (374 aa)
	A306_00014439	Zinc finger protein OZF-like. (456 aa)
	EIF2B4	Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (230 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	BCL2L1	BCL2-like 1. (230 aa)
	BAK1	BCL2-antagonist/killer 1. (217 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa. (653 aa)
	PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (727 aa)
	A306_00011847	Caspase-8, transcript variant X2; Belongs to the peptidase C14A family. (464 aa)
	A306_00011848	Caspase-8, transcript variant X1; Belongs to the peptidase C14A family. (455 aa)
	TICAM1	Toll-like receptor adaptor molecule 1. (610 aa)
	TMEM173	Transmembrane protein 173. (384 aa)
	PVRL1	Poliovirus receptor-related 1 (Herpesvirus entry mediator C), transcript variant X1. (503 aa)
	A306_00013079	Interferon alpha-2. (197 aa)
	SRSF4	Serine/arginine-rich splicing factor 4. (477 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (781 aa)
	SRSF7	Serine/arginine-rich splicing factor 7. (299 aa)
	A306_00011566	Serine/arginine-rich splicing factor 7-like. (303 aa)
	TSC2	Tuberous sclerosis 2. (1142 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	CHUK	Conserved helix-loop-helix ubiquitous kinase. (681 aa)
	TLR2	Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family. (517 aa)
	A306_00011065	Toll-like receptor 2 type-1, transcript variant X1; Belongs to the Toll-like receptor family. (793 aa)
	FAS	Fas cell surface death receptor. (399 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2-alpha kinase 2. (609 aa)
	EIF2B3	Eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa, transcript variant X1. (452 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma), transcript variant X1. (731 aa)
	SRSF3	Serine/arginine-rich splicing factor 3, transcript variant X1. (164 aa)
	IKBKE	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (722 aa)
	TRADD	TNFRSF1A-associated via death domain. (306 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2-alpha kinase 1. (613 aa)
	PIK3R1	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha), transcript variant X1. (724 aa)
	SRC	SRC proto-oncogene, non-receptor tyrosine kinase. (320 aa)
	TNFRSF14	Tumor necrosis factor receptor superfamily, member 14. (256 aa)
	MTOR	Serine/threonine-protein kinase TOR. (1875 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	CASP9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (409 aa)
	A306_00006107	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	C5	Complement component 5. (1677 aa)
	TSC1	Tuberous sclerosis 1, transcript variant X1. (1157 aa)
	CARD9	Caspase recruitment domain family, member 9. (541 aa)
	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (730 aa)
	A306_00006775	Protein PML. (586 aa)
	A306_00006777	Protein PML. (739 aa)
	PDIA3	Protein disulfide-isomerase. (463 aa)
	SRSF2	Serine/arginine-rich splicing factor 2. (205 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (339 aa)
	PTPN11	Protein tyrosine phosphatase, non-receptor type 11. (587 aa)
	EIF2B1	Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (325 aa)
	NFKB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (959 aa)
	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain, transcript variant X1. (278 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	TRAF5	TNF receptor-associated factor. (469 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	RNASEL	Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). (701 aa)
	JAK1	Tyrosine-protein kinase. (699 aa)
	FASLG	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (295 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (611 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	FADD	Fas (TNFRSF6)-associated via death domain. (195 aa)
	IRF7	Interferon regulatory factor 7. (530 aa)
	IFIH1	Interferon induced with helicase C domain 1. (981 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	TBK1	TANK-binding kinase 1. (729 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (498 aa)
	HCFC2	Host cell factor C2. (748 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (191 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (394 aa)
	POU2F1	POU domain protein. (738 aa)
	MAVS	Mitochondrial antiviral signaling protein. (632 aa)
	CASP3	Caspase 3, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (282 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (895 aa)
	EIF2S1	Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa. (315 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. (333 aa)
	A306_00002026	Serine/arginine-rich splicing factor 5. (276 aa)
	SRSF5	Serine/arginine-rich splicing factor 5, transcript variant X2. (265 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1683 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	EIF2B2	Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa; Belongs to the eIF-2B alpha/beta/delta subunits family. (294 aa)
	A306_00002661	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	IL6	Interleukin 6. (150 aa)
	MYD88	Myeloid differentiation primary response 88. (152 aa)
	IFNGR2	Interferon gamma receptor 2 (Interferon gamma transducer 1). (319 aa)
	IFNAR2	Interferon (Alpha, beta and omega) receptor 2, transcript variant X2. (502 aa)
	IFNAR1	Interferon (Alpha, beta and omega) receptor 1. (631 aa)
	IFNGR1	Interferon gamma receptor 1. (410 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	A306_00001131	Zinc finger protein 184. (1088 aa)
	TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2. (688 aa)
	MB21D1	Mab-21 domain containing 1. (313 aa)
	BCL2	B-cell CLL/lymphoma 2. (138 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (269 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00002026	A306_00011566	A0A2I0MNT5	A0A2I0LT57	Serine/arginine-rich splicing factor 5.	Serine/arginine-rich splicing factor 7-like.	0.624
A306_00002026	SRPK1	A0A2I0MNT5	A0A2I0LKP6	Serine/arginine-rich splicing factor 5.	SRSF protein kinase 1; Belongs to the protein kinase superfamily.	0.955
A306_00002026	SRSF2	A0A2I0MNT5	A0A2I0M769	Serine/arginine-rich splicing factor 5.	Serine/arginine-rich splicing factor 2.	0.785
A306_00002026	SRSF3	A0A2I0MNT5	A0A2I0M027	Serine/arginine-rich splicing factor 5.	Serine/arginine-rich splicing factor 3, transcript variant X1.	0.779
A306_00002026	SRSF7	A0A2I0MNT5	A0A2I0LT39	Serine/arginine-rich splicing factor 5.	Serine/arginine-rich splicing factor 7.	0.624
A306_00002661	A306_00011847	A0A2I0MQ77	A0A2I0LQ88	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase-8, transcript variant X2; Belongs to the peptidase C14A family.	0.700
A306_00002661	A306_00011848	A0A2I0MQ77	A0A2I0LQ91	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase-8, transcript variant X1; Belongs to the peptidase C14A family.	0.764
A306_00002661	AKT3	A0A2I0MQ77	A0A2I0MTK2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.476
A306_00002661	APAF1	A0A2I0MQ77	A0A2I0LUL5	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.999
A306_00002661	BAK1	A0A2I0MQ77	A0A2I0LNN2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	BCL2-antagonist/killer 1.	0.976
A306_00002661	BCL2	A0A2I0MQ77	A0A2I0MW17	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	B-cell CLL/lymphoma 2.	0.879
A306_00002661	BCL2L1	A0A2I0MQ77	A0A2I0LMZ0	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	BCL2-like 1.	0.825
A306_00002661	BIRC2	A0A2I0MQ77	A0A2I0MCS5	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Baculoviral IAP repeat containing 2.	0.459
A306_00002661	CASP3	A0A2I0MQ77	A0A2I0MMP4	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase 3, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.889
A306_00002661	CASP9	A0A2I0MQ77	A0A2I0M343	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.998
A306_00002661	FADD	A0A2I0MQ77	A0A2I0MI45	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Fas (TNFRSF6)-associated via death domain.	0.482
A306_00002661	FASLG	A0A2I0MQ77	A0A2I0MCI4	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.	0.491
A306_00002661	IFNGR2	A0A2I0MQ77	A0A2I0MSG2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Interferon gamma receptor 2 (Interferon gamma transducer 1).	0.488
A306_00002661	IL6	A0A2I0MQ77	A0A2I0MQA2	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Interleukin 6.	0.458
A306_00006107	IFNAR2	A0A2I0M3D4	A0A2I0MSG9	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Interferon (Alpha, beta and omega) receptor 2, transcript variant X2.	0.405