(17 nodes) Megakaryocyte differentiation network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_002083	Uncharacterized protein. (481 aa)
	ASZ78_008962	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1660 aa)
	ASZ78_008028	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (613 aa)
	ASZ78_014018	ANK_REP_REGION domain-containing protein. (139 aa)
	ASZ78_000763	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (605 aa)
	ASZ78_011076	WH2 domain-containing protein. (366 aa)
	ASZ78_013803	Ig-like domain-containing protein. (575 aa)
	ASZ78_008123	LRRCT domain-containing protein. (715 aa)
	ASZ78_013235	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (670 aa)
	ASZ78_009853	Uncharacterized protein. (433 aa)
	ASZ78_000072	SH3 domain-containing protein. (292 aa)
	ASZ78_016322	MADS-box domain-containing protein. (437 aa)
	ASZ78_004357	Uncharacterized protein. (2454 aa)
	ASZ78_006159	GATA-type domain-containing protein. (165 aa)
	ASZ78_002684	ThiF domain-containing protein. (361 aa)
	ASZ78_002754	C2H2-type domain-containing protein. (700 aa)
	ASZ78_008328	Uncharacterized protein. (1098 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000072	ASZ78_011076	A0A226MNY1	A0A226MY37	SH3 domain-containing protein.	WH2 domain-containing protein.	0.965
ASZ78_000763	ASZ78_013803	A0A226MYZ6	A0A226MXN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Ig-like domain-containing protein.	0.794
ASZ78_002083	ASZ78_013803	A0A226N973	A0A226MXN6	Uncharacterized protein.	Ig-like domain-containing protein.	0.714
ASZ78_002754	ASZ78_004357	A0A226NE61	A0A226MGM4	C2H2-type domain-containing protein.	Uncharacterized protein.	0.436
ASZ78_002754	ASZ78_006159	A0A226NE61	A0A226MCN2	C2H2-type domain-containing protein.	GATA-type domain-containing protein.	0.431
ASZ78_004357	ASZ78_002754	A0A226MGM4	A0A226NE61	Uncharacterized protein.	C2H2-type domain-containing protein.	0.436
ASZ78_004357	ASZ78_006159	A0A226MGM4	A0A226MCN2	Uncharacterized protein.	GATA-type domain-containing protein.	0.835
ASZ78_004357	ASZ78_008328	A0A226MGM4	A0A226NBQ2	Uncharacterized protein.	Uncharacterized protein.	0.632
ASZ78_004357	ASZ78_008962	A0A226MGM4	A0A226N7Z3	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.660
ASZ78_004357	ASZ78_013235	A0A226MGM4	A0A226MX92	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.660
ASZ78_004357	ASZ78_014018	A0A226MGM4	A0A226N4G6	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.410
ASZ78_006159	ASZ78_002754	A0A226MCN2	A0A226NE61	GATA-type domain-containing protein.	C2H2-type domain-containing protein.	0.431
ASZ78_006159	ASZ78_004357	A0A226MCN2	A0A226MGM4	GATA-type domain-containing protein.	Uncharacterized protein.	0.835
ASZ78_006159	ASZ78_008328	A0A226MCN2	A0A226NBQ2	GATA-type domain-containing protein.	Uncharacterized protein.	0.941
ASZ78_006159	ASZ78_009853	A0A226MCN2	A0A226MSG9	GATA-type domain-containing protein.	Uncharacterized protein.	0.575
ASZ78_006159	ASZ78_016322	A0A226MCN2	A0A226MIP5	GATA-type domain-containing protein.	MADS-box domain-containing protein.	0.765
ASZ78_008328	ASZ78_004357	A0A226NBQ2	A0A226MGM4	Uncharacterized protein.	Uncharacterized protein.	0.632
ASZ78_008328	ASZ78_006159	A0A226NBQ2	A0A226MCN2	Uncharacterized protein.	GATA-type domain-containing protein.	0.941
ASZ78_008962	ASZ78_004357	A0A226N7Z3	A0A226MGM4	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.660
ASZ78_009853	ASZ78_006159	A0A226MSG9	A0A226MCN2	Uncharacterized protein.	GATA-type domain-containing protein.	0.575