(23 nodes) Platelet-derived growth factor receptor signaling pathway network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_010786	Uncharacterized protein; Belongs to the peptidase S1 family. (300 aa)
	ASZ78_014029	Uncharacterized protein. (185 aa)
	ASZ78_006338	Uncharacterized protein. (220 aa)
	ASZ78_014396	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (203 aa)
	ASZ78_005245	Integrin beta; Belongs to the integrin beta chain family. (795 aa)
	ASZ78_013804	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1050 aa)
	ASZ78_014476	Uncharacterized protein; Belongs to the Stoned B family. (732 aa)
	ASZ78_004797	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1085 aa)
	ASZ78_012339	Uncharacterized protein. (2392 aa)
	ASZ78_013968	SH3 domain-containing protein. (914 aa)
	ASZ78_001409	Uncharacterized protein. (363 aa)
	ASZ78_013340	Uncharacterized protein. (452 aa)
	ASZ78_007242	Uncharacterized protein. (216 aa)
	ASZ78_016050	Arrestin_C domain-containing protein. (396 aa)
	ASZ78_000122	Uncharacterized protein. (362 aa)
	ASZ78_005154	Uncharacterized protein. (374 aa)
	ASZ78_016225	CSRNP_N domain-containing protein. (584 aa)
	ASZ78_009580	Uncharacterized protein. (217 aa)
	ASZ78_003215	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (305 aa)
	ASZ78_014626	LAM_G_DOMAIN domain-containing protein. (2177 aa)
	ASZ78_010379	A20-type domain-containing protein. (135 aa)
	ASZ78_004152	Uncharacterized protein. (567 aa)
	ASZ78_008842	Uncharacterized protein. (1361 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_001409	ASZ78_009580	A0A226ME79	A0A226NNS6	Uncharacterized protein.	Uncharacterized protein.	0.976
ASZ78_001409	ASZ78_013804	A0A226ME79	A0A226MXD1	Uncharacterized protein.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.500
ASZ78_001409	ASZ78_013968	A0A226ME79	A0A226MFZ4	Uncharacterized protein.	SH3 domain-containing protein.	0.402
ASZ78_001409	ASZ78_014396	A0A226ME79	A0A226MZW3	Uncharacterized protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.437
ASZ78_003215	ASZ78_004797	A0A226NEU9	A0A226MW37	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.970
ASZ78_003215	ASZ78_005154	A0A226NEU9	A0A226NAI3	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein.	0.730
ASZ78_003215	ASZ78_010786	A0A226NEU9	A0A226N646	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.700
ASZ78_003215	ASZ78_013804	A0A226NEU9	A0A226MXD1	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.983
ASZ78_003215	ASZ78_014396	A0A226NEU9	A0A226MZW3	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.962
ASZ78_004797	ASZ78_003215	A0A226MW37	A0A226NEU9	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	0.970
ASZ78_004797	ASZ78_005154	A0A226MW37	A0A226NAI3	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.705
ASZ78_004797	ASZ78_005245	A0A226MW37	A0A226MZQ1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Integrin beta; Belongs to the integrin beta chain family.	0.462
ASZ78_004797	ASZ78_008842	A0A226MW37	A0A226N7I5	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.486
ASZ78_004797	ASZ78_012339	A0A226MW37	A0A226MGL2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.435
ASZ78_004797	ASZ78_013804	A0A226MW37	A0A226MXD1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.999
ASZ78_004797	ASZ78_013968	A0A226MW37	A0A226MFZ4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	SH3 domain-containing protein.	0.655
ASZ78_004797	ASZ78_014396	A0A226MW37	A0A226MZW3	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.999
ASZ78_004797	ASZ78_014626	A0A226MW37	A0A226NDR7	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	LAM_G_DOMAIN domain-containing protein.	0.435
ASZ78_005154	ASZ78_003215	A0A226NAI3	A0A226NEU9	Uncharacterized protein.	Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family.	0.730
ASZ78_005154	ASZ78_004797	A0A226NAI3	A0A226MW37	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.705