(83 nodes) Negative regulation of canonical Wnt signaling pathway network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_006754	Uncharacterized protein. (2543 aa)
	ASZ78_011041	ANK_REP_REGION domain-containing protein. (814 aa)
	ASZ78_007894	EF-hand domain-containing protein. (399 aa)
	ASZ78_003352	Uncharacterized protein. (482 aa)
	ASZ78_006544	Uncharacterized protein. (410 aa)
	ASZ78_006727	DIX domain-containing protein. (573 aa)
	ASZ78_006726	RGS domain-containing protein. (342 aa)
	ASZ78_006109	WD_REPEATS_REGION domain-containing protein. (455 aa)
	ASZ78_013318	Uncharacterized protein. (1297 aa)
	ASZ78_013345	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (510 aa)
	ASZ78_012443	Uncharacterized protein. (876 aa)
	ASZ78_007268	Uncharacterized protein. (103 aa)
	ASZ78_011790	Dickkopf_N domain-containing protein. (247 aa)
	ASZ78_003866	Uncharacterized protein. (276 aa)
	ASZ78_002498	LRRCT domain-containing protein. (367 aa)
	ASZ78_008080	Uncharacterized protein. (593 aa)
	ASZ78_008086	Uncharacterized protein. (686 aa)
	ASZ78_012309	Uncharacterized protein. (132 aa)
	ASZ78_000812	Dickkopf_N domain-containing protein. (311 aa)
	ASZ78_009731	PID domain-containing protein. (690 aa)
	ASZ78_014407	Uncharacterized protein. (102 aa)
	ASZ78_001249	Uncharacterized protein. (179 aa)
	ASZ78_001516	Uncharacterized protein; Belongs to the peptidase C19 family. (732 aa)
	ASZ78_013676	Uncharacterized protein. (154 aa)
	ASZ78_013667	Uncharacterized protein. (323 aa)
	ASZ78_006278	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (382 aa)
	ASZ78_005795	FZ domain-containing protein. (248 aa)
	ASZ78_013792	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (214 aa)
	ASZ78_004912	zf-RING_14 domain-containing protein. (198 aa)
	ASZ78_010791	Uncharacterized protein. (307 aa)
	ASZ78_008052	Uncharacterized protein. (765 aa)
	ASZ78_008040	BHLH domain-containing protein. (78 aa)
	ASZ78_014207	Uncharacterized protein. (245 aa)
	ASZ78_009928	Uncharacterized protein. (285 aa)
	ASZ78_008782	RING-type domain-containing protein. (802 aa)
	ASZ78_008771	Uncharacterized protein. (369 aa)
	ASZ78_014985	Uncharacterized protein. (404 aa)
	ASZ78_006561	Uncharacterized protein. (804 aa)
	ASZ78_008349	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (666 aa)
	ASZ78_005292	Protein kinase domain-containing protein. (896 aa)
	ASZ78_006233	Cadherin_C domain-containing protein; Cadherins are calcium-dependent cell adhesion proteins. (123 aa)
	ASZ78_006232	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (701 aa)
	ASZ78_015457	CTCK domain-containing protein. (188 aa)
	ASZ78_016067	Uncharacterized protein. (301 aa)
	ASZ78_002689	TPR_REGION domain-containing protein. (1253 aa)
	ASZ78_002714	Uncharacterized protein. (655 aa)
	ASZ78_000653	Uncharacterized protein. (258 aa)
	ASZ78_011895	Hist_deacetyl domain-containing protein. (426 aa)
	ASZ78_015837	HMG box domain-containing protein. (608 aa)
	ASZ78_010874	Uncharacterized protein. (643 aa)
	ASZ78_010734	Uncharacterized protein. (1137 aa)
	ASZ78_010915	Uncharacterized protein. (312 aa)
	ASZ78_016773	Uncharacterized protein. (1141 aa)
	ASZ78_014147	Uncharacterized protein. (316 aa)
	ASZ78_014360	Dickkopf_N domain-containing protein. (184 aa)
	ASZ78_005348	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	ASZ78_004876	Uncharacterized protein. (363 aa)
	ASZ78_003461	Mothers against decapentaplegic homolog. (408 aa)
	ASZ78_008081	TLE_N domain-containing protein. (247 aa)
	ASZ78_005005	Uncharacterized protein. (1399 aa)
	ASZ78_006773	Uncharacterized protein. (1125 aa)
	ASZ78_012732	Uncharacterized protein. (842 aa)
	ASZ78_000323	Uncharacterized protein. (596 aa)
	ASZ78_005984	Noggin; Belongs to the noggin family. (223 aa)
	ASZ78_001885	CTCK domain-containing protein. (206 aa)
	ASZ78_013296	Homeobox domain-containing protein. (292 aa)
	ASZ78_011737	Uncharacterized protein. (232 aa)
	ASZ78_008243	HMG box domain-containing protein. (496 aa)
	ASZ78_008290	Uncharacterized protein. (1064 aa)
	ASZ78_011027	Non-specific serine/threonine protein kinase. (1092 aa)
	SDHAF2	Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (157 aa)
	ASZ78_002414	Uncharacterized protein. (768 aa)
	ASZ78_017030	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (229 aa)
	ASZ78_014674	ICAT domain-containing protein. (83 aa)
	ASZ78_003240	FZ domain-containing protein. (270 aa)
	ASZ78_011417	CTCK domain-containing protein. (213 aa)
	ASZ78_002861	Uncharacterized protein. (86 aa)
	ASZ78_016313	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (525 aa)
	ASZ78_002863	Uncharacterized protein. (105 aa)
	ASZ78_015532	MCC-bdg_PDZ domain-containing protein. (718 aa)
	ASZ78_015528	Uncharacterized protein. (2735 aa)
	ASZ78_013194	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (355 aa)
	ASZ78_013367	SAM domain-containing protein. (813 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000653	ASZ78_002714	A0A226NFM3	A0A226NEJ1	Uncharacterized protein.	Uncharacterized protein.	0.443
ASZ78_000653	ASZ78_003240	A0A226NFM3	A0A226MLQ3	Uncharacterized protein.	FZ domain-containing protein.	0.603
ASZ78_000653	ASZ78_005348	A0A226NFM3	A0A226NN24	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.518
ASZ78_000653	ASZ78_008782	A0A226NFM3	A0A226NAQ3	Uncharacterized protein.	RING-type domain-containing protein.	0.520
ASZ78_000653	ASZ78_013194	A0A226NFM3	A0A226MI83	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.475
ASZ78_000653	ASZ78_013792	A0A226NFM3	A0A226N4M2	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.816
ASZ78_000653	ASZ78_014985	A0A226NFM3	A0A226NAV0	Uncharacterized protein.	Uncharacterized protein.	0.603
ASZ78_000653	ASZ78_016313	A0A226NFM3	A0A226MKE2	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.670
ASZ78_000812	ASZ78_003240	A0A226MYI6	A0A226MLQ3	Dickkopf_N domain-containing protein.	FZ domain-containing protein.	0.541
ASZ78_000812	ASZ78_006561	A0A226MYI6	A0A226NB34	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.511
ASZ78_000812	ASZ78_007894	A0A226MYI6	A0A226MH45	Dickkopf_N domain-containing protein.	EF-hand domain-containing protein.	0.408
ASZ78_000812	ASZ78_008771	A0A226MYI6	A0A226NAR0	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.620
ASZ78_000812	ASZ78_009731	A0A226MYI6	A0A226MYV9	Dickkopf_N domain-containing protein.	PID domain-containing protein.	0.777
ASZ78_000812	ASZ78_010791	A0A226MYI6	A0A226N575	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.568
ASZ78_000812	ASZ78_011790	A0A226MYI6	A0A226ME61	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.561
ASZ78_000812	ASZ78_013792	A0A226MYI6	A0A226N4M2	Dickkopf_N domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.400
ASZ78_000812	ASZ78_014360	A0A226MYI6	A0A226NM41	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.519
ASZ78_000812	ASZ78_014985	A0A226MYI6	A0A226NAV0	Dickkopf_N domain-containing protein.	Uncharacterized protein.	0.545
ASZ78_001516	ASZ78_011041	A0A226N0F9	A0A226MH54	Uncharacterized protein; Belongs to the peptidase C19 family.	ANK_REP_REGION domain-containing protein.	0.632
ASZ78_001516	ASZ78_012443	A0A226N0F9	A0A226MEI6	Uncharacterized protein; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.919