(111 nodes) Organic hydroxy compound biosynthetic process network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_007594	Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
	ASZ78_008941	Uncharacterized protein. (229 aa)
	ASZ78_008824	BH4_AAA_HYDROXYL_2 domain-containing protein. (491 aa)
	ASZ78_013277	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	ASZ78_004126	Kinase; Belongs to the inositol phosphokinase (IPK) family. (346 aa)
	ASZ78_004153	Uncharacterized protein. (104 aa)
	ASZ78_002897	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (249 aa)
	ASZ78_004975	Uncharacterized protein. (546 aa)
	ASZ78_005149	Uncharacterized protein. (325 aa)
	ASZ78_016017	Non-specific serine/threonine protein kinase. (475 aa)
	ASZ78_016022	FAD-binding PCMH-type domain-containing protein. (516 aa)
	ASZ78_008347	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (362 aa)
	ASZ78_000220	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (746 aa)
	ASZ78_004431	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (288 aa)
	ASZ78_012995	Uncharacterized protein. (645 aa)
	ASZ78_004240	3-hydroxy-3-methylglutaryl coenzyme A reductase. (892 aa)
	ASZ78_011916	G_PROTEIN_RECEP_F1_2 domain-containing protein. (368 aa)
	ASZ78_013108	Uncharacterized protein. (394 aa)
	ASZ78_003012	Inositol-1-monophosphatase. (292 aa)
	ASZ78_017050	Nudix hydrolase domain-containing protein. (177 aa)
	ASZ78_003550	Uncharacterized protein. (140 aa)
	ASZ78_005704	Uncharacterized protein; Belongs to the cytochrome P450 family. (603 aa)
	ASZ78_010926	Aspartate aminotransferase. (412 aa)
	ASZ78_002811	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (234 aa)
	ASZ78_010026	DOMON domain-containing protein. (506 aa)
	ASZ78_000420	Kinase; Belongs to the inositol phosphokinase (IPK) family. (400 aa)
	ASZ78_015267	Tudor domain-containing protein. (608 aa)
	ASZ78_002197	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1526 aa)
	ASZ78_002237	Uncharacterized protein. (382 aa)
	ASZ78_009530	DOMON domain-containing protein. (672 aa)
	ASZ78_011324	Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
	ASZ78_009031	Uncharacterized protein. (62 aa)
	ASZ78_004110	Glucosylceramidase. (188 aa)
	ASZ78_016165	Glucosylceramidase. (279 aa)
	ASZ78_004919	Neutral ceramidase. (357 aa)
	ASZ78_010238	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
	ASZ78_002559	Ceramidse_alk_C domain-containing protein. (72 aa)
	ASZ78_002557	Neutral ceramidase. (625 aa)
	ASZ78_007683	Kinase; Belongs to the inositol phosphokinase (IPK) family. (417 aa)
	ASZ78_014927	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (351 aa)
	ASZ78_014932	RUN domain-containing protein. (561 aa)
	ASZ78_014930	Uncharacterized protein. (111 aa)
	ASZ78_012290	Uncharacterized protein. (325 aa)
	ASZ78_001388	Uncharacterized protein; Belongs to the cytochrome P450 family. (394 aa)
	ASZ78_009033	Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
	ASZ78_015103	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (274 aa)
	ASZ78_015383	Uncharacterized protein. (193 aa)
	ASZ78_016584	Uncharacterized protein. (445 aa)
	ASZ78_002298	TGF_BETA_2 domain-containing protein. (199 aa)
	ASZ78_014062	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	ASZ78_013008	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (304 aa)
	ASZ78_015630	Alkyl transferase; Belongs to the UPP synthase family. (261 aa)
	ASZ78_011148	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (539 aa)
	ASZ78_009107	AdenylateSensor domain-containing protein. (301 aa)
	ASZ78_016959	Kinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
	ASZ78_004315	CitMHS domain-containing protein. (710 aa)
	ASZ78_001895	BH4_AAA_HYDROXYL_2 domain-containing protein. (337 aa)
	ASZ78_015434	Kinase; Belongs to the inositol phosphokinase (IPK) family. (512 aa)
	ASZ78_008296	C3H1-type domain-containing protein. (229 aa)
	ASZ78_003850	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (276 aa)
	ASZ78_008520	PKS_ER domain-containing protein. (319 aa)
	ASZ78_017026	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1368 aa)
	ASZ78_005752	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1031 aa)
	ASZ78_010171	Uncharacterized protein. (219 aa)
	ASZ78_010560	Uncharacterized protein. (542 aa)
	ASZ78_000169	Uncharacterized protein. (332 aa)
	ASZ78_000156	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (368 aa)
	ASZ78_008267	DAGKc domain-containing protein. (368 aa)
	ASZ78_006939	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (342 aa)
	ASZ78_006416	Uncharacterized protein. (153 aa)
	ASZ78_008462	Uncharacterized protein. (552 aa)
	ASZ78_002451	Uncharacterized protein. (474 aa)
	ASZ78_013441	Inositol-1-monophosphatase. (199 aa)
	ASZ78_013442	Uncharacterized protein. (75 aa)
	ASZ78_003855	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (296 aa)
	ASZ78_016858	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (346 aa)
	ASZ78_007663	Uncharacterized protein. (148 aa)
	ASZ78_012552	Uncharacterized protein. (491 aa)
	ASZ78_011854	Uncharacterized protein. (622 aa)
	ASZ78_004216	Uncharacterized protein. (262 aa)
	ASZ78_004467	Uncharacterized protein. (322 aa)
	ASZ78_010094	Uncharacterized protein. (474 aa)
	ASZ78_004987	DJ-1_PfpI domain-containing protein. (189 aa)
	ASZ78_001998	Uncharacterized protein. (58 aa)
	ASZ78_002364	Phos_pyr_kin domain-containing protein. (300 aa)
	ASZ78_017010	Uncharacterized protein. (507 aa)
	ASZ78_014435	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily. (286 aa)
	ASZ78_008434	Kinase; Belongs to the inositol phosphokinase (IPK) family. (465 aa)
	ASZ78_015541	Uncharacterized protein. (452 aa)
	ASZ78_010220	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (680 aa)
	ASZ78_006291	R3H domain-containing protein. (260 aa)
	ASZ78_002311	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
	ASZ78_004564	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	ASZ78_013996	Uncharacterized protein. (177 aa)
	ASZ78_001715	Uncharacterized protein. (418 aa)
	ASZ78_015337	DAO domain-containing protein. (306 aa)
	ASZ78_015349	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (409 aa)
	ASZ78_013256	SE domain-containing protein. (602 aa)
	ASZ78_014459	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (201 aa)
	ASZ78_013785	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (236 aa)
	ASZ78_009456	Uncharacterized protein. (375 aa)
	ASZ78_009348	Uncharacterized protein. (575 aa)
	ASZ78_009455	Uncharacterized protein. (264 aa)
	ASZ78_008013	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1454 aa)
	ASZ78_003112	Uncharacterized protein. (268 aa)
	ASZ78_011194	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (423 aa)
	ASZ78_011213	Uncharacterized protein. (564 aa)
	ASZ78_001929	Uncharacterized protein. (437 aa)
	ASZ78_001927	Uncharacterized protein. (466 aa)
	ASZ78_000308	Uncharacterized protein. (440 aa)
	ASZ78_001928	Uncharacterized protein. (461 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000156	ASZ78_000169	A0A226MRB1	A0A226MRA3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.611
ASZ78_000156	ASZ78_001388	A0A226MRB1	A0A226MF39	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.570
ASZ78_000156	ASZ78_001715	A0A226MRB1	A0A226N336	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.872
ASZ78_000156	ASZ78_002897	A0A226MRB1	A0A226N8S6	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.482
ASZ78_000156	ASZ78_003112	A0A226MRB1	A0A226N655	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.444
ASZ78_000156	ASZ78_003855	A0A226MRB1	A0A226MTI3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.690
ASZ78_000156	ASZ78_004216	A0A226MRB1	A0A226MVL9	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.444
ASZ78_000156	ASZ78_004240	A0A226MRB1	A0A226NFG1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.995
ASZ78_000156	ASZ78_004431	A0A226MRB1	A0A226NDY4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.731
ASZ78_000156	ASZ78_005704	A0A226MRB1	A0A226NHP0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.617
ASZ78_000156	ASZ78_006291	A0A226MRB1	A0A226N1X6	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	R3H domain-containing protein.	0.496
ASZ78_000156	ASZ78_007594	A0A226MRB1	A0A226N7F6	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.570
ASZ78_000156	ASZ78_008347	A0A226MRB1	A0A226NBT0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.834
ASZ78_000156	ASZ78_009031	A0A226MRB1	A0A226M6V9	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.576
ASZ78_000156	ASZ78_009033	A0A226MRB1	A0A226MFE3	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.892
ASZ78_000156	ASZ78_010094	A0A226MRB1	A0A226MWV1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.592
ASZ78_000156	ASZ78_010220	A0A226MRB1	A0A226N1L1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.748
ASZ78_000156	ASZ78_010238	A0A226MRB1	A0A226MBQ5	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.576
ASZ78_000156	ASZ78_010560	A0A226MRB1	A0A226MQS4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.422
ASZ78_000156	ASZ78_011148	A0A226MRB1	A0A226MKB4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.916