(49 nodes) Regulation of TP53 Activity through Phosphorylation network (Callipepla squamata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	ASZ78_004874	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (698 aa)
	ASZ78_015014	Protein kinase domain-containing protein. (245 aa)
	ASZ78_013949	Uncharacterized protein. (228 aa)
	ASZ78_015704	Protein kinase domain-containing protein. (644 aa)
	ASZ78_002211	Uncharacterized protein. (520 aa)
	ASZ78_010035	Uncharacterized protein. (143 aa)
	ASZ78_013754	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (310 aa)
	ASZ78_004553	Protein kinase domain-containing protein. (1216 aa)
	ASZ78_004931	Uncharacterized protein. (864 aa)
	ASZ78_001770	KxDL domain-containing protein. (176 aa)
	ASZ78_015478	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
	ASZ78_009871	Uncharacterized protein. (568 aa)
	ASZ78_012300	UBA domain-containing protein. (446 aa)
	ASZ78_003595	Uncharacterized protein. (381 aa)
	ASZ78_011234	Helicase C-terminal domain-containing protein. (159 aa)
	ASZ78_011233	Helicase ATP-binding domain-containing protein. (370 aa)
	ASZ78_017017	Helicase C-terminal domain-containing protein. (213 aa)
	ASZ78_013225	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (169 aa)
	ASZ78_012868	Dna2 domain-containing protein. (117 aa)
	ASZ78_017109	Uncharacterized protein. (293 aa)
	ASZ78_005495	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (358 aa)
	ASZ78_015818	Protein kinase domain-containing protein. (620 aa)
	ASZ78_015798	Protein kinase domain-containing protein. (575 aa)
	ASZ78_015831	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (467 aa)
	ASZ78_010260	3'-5' exonuclease domain-containing protein. (620 aa)
	ASZ78_004241	ANK_REP_REGION domain-containing protein. (583 aa)
	ASZ78_002752	zf-4CXXC_R1 domain-containing protein. (420 aa)
	ASZ78_001268	Uncharacterized protein. (442 aa)
	ASZ78_006278	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (382 aa)
	ASZ78_011092	TFIID_20kDa domain-containing protein. (198 aa)
	ASZ78_003587	ANK_REP_REGION domain-containing protein. (807 aa)
	ASZ78_012635	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (706 aa)
	ASZ78_004370	Mre11_DNA_bind domain-containing protein. (594 aa)
	ASZ78_009095	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (350 aa)
	ASZ78_000858	PWWP domain-containing protein. (786 aa)
	ASZ78_009360	Uncharacterized protein. (142 aa)
	ASZ78_011757	Uncharacterized protein. (168 aa)
	ASZ78_002938	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
	ASZ78_002947	Protein kinase domain-containing protein. (545 aa)
	ASZ78_005799	Mitogen-activated protein kinase. (351 aa)
	ASZ78_001351	Uncharacterized protein. (691 aa)
	ASZ78_008140	DUF1767 domain-containing protein. (623 aa)
	ASZ78_006492	Uncharacterized protein. (255 aa)
	ASZ78_008042	Uncharacterized protein. (1066 aa)
	ASZ78_015403	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2168 aa)
	ASZ78_008234	Uncharacterized protein. (306 aa)
	ASZ78_004974	Uncharacterized protein. (637 aa)
	ASZ78_017094	Uncharacterized protein. (619 aa)
	ASZ78_004898	Uncharacterized protein. (237 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000858	ASZ78_001351	A0A226MRS0	A0A226N2X1	PWWP domain-containing protein.	Uncharacterized protein.	0.515
ASZ78_000858	ASZ78_002211	A0A226MRS0	A0A226NM04	PWWP domain-containing protein.	Uncharacterized protein.	0.795
ASZ78_000858	ASZ78_002752	A0A226MRS0	A0A226NE63	PWWP domain-containing protein.	zf-4CXXC_R1 domain-containing protein.	0.821
ASZ78_000858	ASZ78_002938	A0A226MRS0	A0A226MP57	PWWP domain-containing protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.611
ASZ78_000858	ASZ78_002947	A0A226MRS0	A0A226MP23	PWWP domain-containing protein.	Protein kinase domain-containing protein.	0.515
ASZ78_000858	ASZ78_003587	A0A226MRS0	A0A226MY28	PWWP domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.877
ASZ78_000858	ASZ78_004370	A0A226MRS0	A0A226MUG2	PWWP domain-containing protein.	Mre11_DNA_bind domain-containing protein.	0.971
ASZ78_000858	ASZ78_004553	A0A226MRS0	A0A226MMD4	PWWP domain-containing protein.	Protein kinase domain-containing protein.	0.515
ASZ78_000858	ASZ78_004874	A0A226MRS0	A0A226NPL8	PWWP domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.983
ASZ78_000858	ASZ78_004931	A0A226MRS0	A0A226MMD0	PWWP domain-containing protein.	Uncharacterized protein.	0.400
ASZ78_000858	ASZ78_008042	A0A226MRS0	A0A226N5G2	PWWP domain-containing protein.	Uncharacterized protein.	0.796
ASZ78_000858	ASZ78_008140	A0A226MRS0	A0A226N4V1	PWWP domain-containing protein.	DUF1767 domain-containing protein.	0.528
ASZ78_000858	ASZ78_009871	A0A226MRS0	A0A226MHU5	PWWP domain-containing protein.	Uncharacterized protein.	0.528
ASZ78_000858	ASZ78_010260	A0A226MRS0	A0A226NHV5	PWWP domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.620
ASZ78_000858	ASZ78_011233	A0A226MRS0	A0A226MC35	PWWP domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.796
ASZ78_000858	ASZ78_011234	A0A226MRS0	A0A226MC46	PWWP domain-containing protein.	Helicase C-terminal domain-containing protein.	0.796
ASZ78_000858	ASZ78_012300	A0A226MRS0	A0A226MHA0	PWWP domain-containing protein.	UBA domain-containing protein.	0.528
ASZ78_000858	ASZ78_012868	A0A226MRS0	A0A226M7P9	PWWP domain-containing protein.	Dna2 domain-containing protein.	0.815
ASZ78_000858	ASZ78_013225	A0A226MRS0	A0A226M7V5	PWWP domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.485
ASZ78_000858	ASZ78_013754	A0A226MRS0	A0A226MN68	PWWP domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.485