(42 nodes) Fatty acid elongation network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_014364	Uncharacterized protein. (318 aa)
	ASZ78_012268	Elongation of very long chain fatty acids protein. (215 aa)
	ASZ78_000402	Uncharacterized protein. (103 aa)
	ASZ78_015221	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (132 aa)
	ASZ78_012451	Uncharacterized protein. (373 aa)
	ELOVL4	Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (313 aa)
	ASZ78_010440	Elongation of very long chain fatty acids protein. (128 aa)
	ASZ78_015036	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (209 aa)
	ASZ78_001926	Uncharacterized protein. (213 aa)
	ASZ78_001928	Uncharacterized protein. (461 aa)
	ELOVL2	Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (297 aa)
	ASZ78_001927	Uncharacterized protein. (466 aa)
	ASZ78_001929	Uncharacterized protein. (437 aa)
	ASZ78_016245	Elongation of very long chain fatty acids protein. (297 aa)
	ASZ78_009337	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (186 aa)
	ASZ78_014865	C2H2-type domain-containing protein. (332 aa)
	ASZ78_001354	DEP domain-containing protein. (520 aa)
	ASZ78_001353	Uncharacterized protein. (514 aa)
	ASZ78_008478	Uncharacterized protein. (189 aa)
	ASZ78_016825	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	ASZ78_008424	Elongation of very long chain fatty acids protein. (252 aa)
	ASZ78_005007	Uncharacterized protein. (352 aa)
	ASZ78_001875	Elongation of very long chain fatty acids protein. (252 aa)
	ASZ78_002469	Uncharacterized protein. (146 aa)
	ASZ78_002470	S5A_REDUCTASE domain-containing protein. (136 aa)
	ASZ78_003920	S5A_REDUCTASE domain-containing protein. (312 aa)
	ASZ78_007259	Uncharacterized protein. (419 aa)
	ASZ78_010670	Uncharacterized protein. (256 aa)
	ASZ78_016951	Uncharacterized protein. (3082 aa)
	ASZ78_010315	PKS_ER domain-containing protein. (281 aa)
	ASZ78_008490	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (872 aa)
	ASZ78_000024	4HBT domain-containing protein. (210 aa)
	ASZ78_008492	Thiolase_N domain-containing protein. (324 aa)
	ASZ78_003448	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (325 aa)
	ASZ78_015701	Uncharacterized protein. (505 aa)
	ASZ78_008670	Uncharacterized protein. (122 aa)
	ASZ78_014517	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (380 aa)
	ASZ78_003154	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (320 aa)
	ASZ78_007538	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	ASZ78_009417	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (278 aa)
	ASZ78_009163	Elongation of very long chain fatty acids protein. (128 aa)
	ELOVL1	Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (290 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000024	ASZ78_001927	A0A226MF16	A0A226N728	4HBT domain-containing protein.	Uncharacterized protein.	0.947
ASZ78_000024	ASZ78_001928	A0A226MF16	A0A226N792	4HBT domain-containing protein.	Uncharacterized protein.	0.947
ASZ78_000024	ASZ78_001929	A0A226MF16	A0A226N6Y1	4HBT domain-containing protein.	Uncharacterized protein.	0.907
ASZ78_000024	ASZ78_005007	A0A226MF16	A0A226MXF1	4HBT domain-containing protein.	Uncharacterized protein.	0.913
ASZ78_000024	ASZ78_007259	A0A226MF16	A0A226MNE6	4HBT domain-containing protein.	Uncharacterized protein.	0.918
ASZ78_000402	ASZ78_002469	A0A226NL84	A0A226MUJ3	Uncharacterized protein.	Uncharacterized protein.	0.531
ASZ78_000402	ASZ78_002470	A0A226NL84	A0A226MUI2	Uncharacterized protein.	S5A_REDUCTASE domain-containing protein.	0.531
ASZ78_000402	ASZ78_003920	A0A226NL84	A0A226MRQ5	Uncharacterized protein.	S5A_REDUCTASE domain-containing protein.	0.531
ASZ78_001353	ASZ78_002469	A0A226N227	A0A226MUJ3	Uncharacterized protein.	Uncharacterized protein.	0.531
ASZ78_001353	ASZ78_002470	A0A226N227	A0A226MUI2	Uncharacterized protein.	S5A_REDUCTASE domain-containing protein.	0.531
ASZ78_001353	ASZ78_003920	A0A226N227	A0A226MRQ5	Uncharacterized protein.	S5A_REDUCTASE domain-containing protein.	0.531
ASZ78_001354	ASZ78_002469	A0A226N252	A0A226MUJ3	DEP domain-containing protein.	Uncharacterized protein.	0.531
ASZ78_001354	ASZ78_002470	A0A226N252	A0A226MUI2	DEP domain-containing protein.	S5A_REDUCTASE domain-containing protein.	0.531
ASZ78_001354	ASZ78_003920	A0A226N252	A0A226MRQ5	DEP domain-containing protein.	S5A_REDUCTASE domain-containing protein.	0.531
ASZ78_001875	ASZ78_002469	A0A226MWP0	A0A226MUJ3	Elongation of very long chain fatty acids protein.	Uncharacterized protein.	0.719
ASZ78_001875	ASZ78_002470	A0A226MWP0	A0A226MUI2	Elongation of very long chain fatty acids protein.	S5A_REDUCTASE domain-containing protein.	0.719
ASZ78_001875	ASZ78_003448	A0A226MWP0	A0A226NPC6	Elongation of very long chain fatty acids protein.	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	0.924
ASZ78_001875	ASZ78_003920	A0A226MWP0	A0A226MRQ5	Elongation of very long chain fatty acids protein.	S5A_REDUCTASE domain-containing protein.	0.950
ASZ78_001875	ASZ78_008424	A0A226MWP0	A0A226MY34	Elongation of very long chain fatty acids protein.	Elongation of very long chain fatty acids protein.	0.519
ASZ78_001875	ASZ78_008478	A0A226MWP0	A0A226N1Y4	Elongation of very long chain fatty acids protein.	Uncharacterized protein.	0.920