(60 nodes) Tryptophan metabolism network (Callipepla squamata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ASZ78_014191	MIT domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
	ASZ78_016456	Uncharacterized protein; Belongs to the cytochrome P450 family. (565 aa)
	ASZ78_007190	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (514 aa)
	AFMID	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (234 aa)
	ASZ78_014400	Tr-type G domain-containing protein. (668 aa)
	ASZ78_002087	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (519 aa)
	ASZ78_003685	Amine oxidase. (746 aa)
	ASZ78_001599	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (738 aa)
	ASZ78_016461	Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
	ASZ78_011722	Uncharacterized protein; Belongs to the cytochrome P450 family. (517 aa)
	ASZ78_001895	BH4_AAA_HYDROXYL_2 domain-containing protein. (337 aa)
	ASZ78_008806	AAA domain-containing protein. (708 aa)
	ASZ78_000563	Amidase domain-containing protein. (481 aa)
	ASZ78_007535	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	ASZ78_008271	N-acetyltransferase domain-containing protein. (205 aa)
	ASZ78_006244	Transket_pyr domain-containing protein. (835 aa)
	ASZ78_002088	APH domain-containing protein. (421 aa)
	ASZ78_013728	Aminotran_1_2 domain-containing protein. (477 aa)
	ASZ78_011379	AAA domain-containing protein; Belongs to the AAA ATPase family. (747 aa)
	ASZ78_005336	Uncharacterized protein. (506 aa)
	ASZ78_005878	PH domain-containing protein. (574 aa)
	ASZ78_006515	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (482 aa)
	ASZ78_010797	Uncharacterized protein. (400 aa)
	ASZ78_015406	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	ASZ78_010215	Uncharacterized protein. (127 aa)
	ASZ78_002319	Uncharacterized protein. (679 aa)
	ASZ78_005072	Uncharacterized protein; Belongs to the cytochrome P450 family. (542 aa)
	ASZ78_014838	Uncharacterized protein. (289 aa)
	ASZ78_003212	Uncharacterized protein. (416 aa)
	ASZ78_012447	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (518 aa)
	ASZ78_014010	Uncharacterized protein. (605 aa)
	ASZ78_014007	Methyltransf_2 domain-containing protein. (271 aa)
	ASZ78_003539	Lipoyl-binding domain-containing protein. (461 aa)
	ASZ78_002797	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (379 aa)
	ASZ78_000483	Uncharacterized protein. (500 aa)
	ASZ78_000482	Uncharacterized protein. (983 aa)
	ASZ78_010042	Aldedh domain-containing protein. (103 aa)
	ASZ78_014364	Uncharacterized protein. (318 aa)
	ASZ78_001135	FAD-binding PCMH-type domain-containing protein. (1644 aa)
	ASZ78_010041	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (289 aa)
	ASZ78_009602	Aminotran_1_2 domain-containing protein. (453 aa)
	ASZ78_007436	Dihydrolipoyl dehydrogenase. (508 aa)
	ASZ78_011074	Uncharacterized protein. (691 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (426 aa)
	ASZ78_002451	Uncharacterized protein. (474 aa)
	ASZ78_009417	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (278 aa)
	ASZ78_017010	Uncharacterized protein. (507 aa)
	ASZ78_017009	AAA domain-containing protein; Belongs to the AAA ATPase family. (697 aa)
	ASZ78_006250	Aminotran_1_2 domain-containing protein. (153 aa)
	ASZ78_001365	Amine oxidase. (496 aa)
	ASZ78_001364	Amine oxidase. (551 aa)
	ASZ78_015771	Uncharacterized protein. (216 aa)
	ASZ78_007538	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	ASZ78_010214	Uncharacterized protein. (142 aa)
	ASZ78_003154	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (320 aa)
	ASZ78_014517	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (380 aa)
	ASZ78_010310	FAD-binding PCMH-type domain-containing protein. (180 aa)
	ASZ78_003402	Amine oxidase. (527 aa)
	ASZ78_008490	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (872 aa)
	ASZ78_002872	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFMID	ASZ78_002797	A0A226N0I3	A0A226NJ35	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.475
AFMID	ASZ78_003212	A0A226N0I3	A0A226NEN2	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.960
AFMID	ASZ78_005878	A0A226N0I3	A0A226NMY0	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	PH domain-containing protein.	0.961
AFMID	ASZ78_006250	A0A226N0I3	A0A226MJM8	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Aminotran_1_2 domain-containing protein.	0.937
AFMID	ASZ78_008806	A0A226N0I3	A0A226MMN9	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	AAA domain-containing protein.	0.533
AFMID	ASZ78_009602	A0A226N0I3	A0A226NMT4	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Aminotran_1_2 domain-containing protein.	0.935
AFMID	ASZ78_010214	A0A226N0I3	A0A226N1W0	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.943
AFMID	ASZ78_010215	A0A226N0I3	A0A226N2J5	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.943
AFMID	ASZ78_010797	A0A226N0I3	A0A226N5Z1	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.941
AFMID	ASZ78_011379	A0A226N0I3	A0A226NQ40	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.533
AFMID	ASZ78_013728	A0A226N0I3	A0A226N700	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Aminotran_1_2 domain-containing protein.	0.937
AFMID	ASZ78_014007	A0A226N0I3	A0A226NFL8	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Methyltransf_2 domain-containing protein.	0.442
AFMID	ASZ78_014010	A0A226N0I3	A0A226NFB3	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.456
AFMID	ASZ78_014191	A0A226N0I3	A0A226MI09	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	MIT domain-containing protein; Belongs to the AAA ATPase family.	0.533
AFMID	ASZ78_014838	A0A226N0I3	A0A226NDB5	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.500
AFMID	ASZ78_017009	A0A226N0I3	A0A226MZ12	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.533
AFMID	ASZ78_017010	A0A226N0I3	A0A226MZ41	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Uncharacterized protein.	0.918
AFMID	KATNAL2	A0A226N0I3	A0A226MV23	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.560
ASZ78_000482	ASZ78_001135	A0A226NLJ6	A0A226MZC7	Uncharacterized protein.	FAD-binding PCMH-type domain-containing protein.	0.475
ASZ78_000482	ASZ78_001364	A0A226NLJ6	A0A226MJR6	Uncharacterized protein.	Amine oxidase.	0.616