(42 nodes) Folate biosynthesis network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_004216	Uncharacterized protein. (262 aa)
	ASZ78_009621	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (557 aa)
	ASZ78_012840	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (218 aa)
	ASZ78_015722	Uncharacterized protein. (859 aa)
	ASZ78_014272	Uncharacterized protein. (238 aa)
	ASZ78_003007	PRELI/MSF1 domain-containing protein. (192 aa)
	ASZ78_008208	Uncharacterized protein. (414 aa)
	ASZ78_003721	MOSC domain-containing protein. (511 aa)
	ASZ78_008854	Elp3 domain-containing protein. (649 aa)
	ASZ78_004153	Uncharacterized protein. (104 aa)
	ASZ78_008824	BH4_AAA_HYDROXYL_2 domain-containing protein. (491 aa)
	ASZ78_014208	Uncharacterized protein. (608 aa)
	ASZ78_007597	Folate gamma-glutamyl hydrolase. (309 aa)
	GFM1	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] (719 aa)
	ASZ78_003112	Uncharacterized protein. (268 aa)
	ASZ78_014181	Uncharacterized protein. (380 aa)
	ASZ78_012686	Uncharacterized protein. (252 aa)
	ASZ78_010499	Alkaline phosphatase. (520 aa)
	ASZ78_003752	FAM193_C domain-containing protein. (893 aa)
	ASZ78_003753	Uncharacterized protein. (617 aa)
	ASZ78_003748	PRELI/MSF1 domain-containing protein. (261 aa)
	ASZ78_012690	Aldo_ket_red domain-containing protein. (314 aa)
	ASZ78_006074	Alkaline phosphatase. (525 aa)
	ASZ78_001138	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. (373 aa)
	ASZ78_001998	Uncharacterized protein. (58 aa)
	ASZ78_014459	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (201 aa)
	ASZ78_012688	Aldo_ket_red domain-containing protein. (303 aa)
	ASZ78_012689	Uncharacterized protein. (353 aa)
	ASZ78_012290	Uncharacterized protein. (325 aa)
	ASZ78_000062	tRNA (guanine(26)-N(2))-dimethyltransferase. (636 aa)
	ASZ78_007627	Aldo_ket_red domain-containing protein. (144 aa)
	ASZ78_001493	Aldo_ket_red domain-containing protein. (157 aa)
	ASZ78_012691	Aldo_ket_red domain-containing protein. (254 aa)
	ASZ78_012692	Aldo_ket_red domain-containing protein. (92 aa)
	ASZ78_001895	BH4_AAA_HYDROXYL_2 domain-containing protein. (337 aa)
	ASZ78_011825	PDZ domain-containing protein. (189 aa)
	ASZ78_010578	PRELI/MSF1 domain-containing protein. (194 aa)
	ASZ78_012517	FSH1 domain-containing protein. (226 aa)
	ASZ78_002451	Uncharacterized protein. (474 aa)
	ASZ78_007663	Uncharacterized protein. (148 aa)
	MOCS2	Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. (155 aa)
	ASZ78_010502	Alkaline phosphatase. (501 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_001138	ASZ78_007663	A0A226MZ38	A0A226MUP4	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.	Uncharacterized protein.	0.852
ASZ78_001138	ASZ78_008854	A0A226MZ38	A0A226NE56	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.	Elp3 domain-containing protein.	0.811
ASZ78_001138	ASZ78_012290	A0A226MZ38	A0A226MER3	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.	Uncharacterized protein.	0.888
ASZ78_001493	ASZ78_001895	A0A226M8L1	A0A226MM97	Aldo_ket_red domain-containing protein.	BH4_AAA_HYDROXYL_2 domain-containing protein.	0.866
ASZ78_001493	ASZ78_002451	A0A226M8L1	A0A226MTC5	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.866
ASZ78_001493	ASZ78_003112	A0A226M8L1	A0A226N655	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.876
ASZ78_001493	ASZ78_004216	A0A226M8L1	A0A226MVL9	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.889
ASZ78_001493	ASZ78_007663	A0A226M8L1	A0A226MUP4	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.786
ASZ78_001493	ASZ78_012686	A0A226M8L1	A0A226MJY9	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.557
ASZ78_001493	ASZ78_012692	A0A226M8L1	A0A226MKN5	Aldo_ket_red domain-containing protein.	Aldo_ket_red domain-containing protein.	0.556
ASZ78_001493	ASZ78_014272	A0A226M8L1	A0A226NLR2	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.593
ASZ78_001493	ASZ78_014459	A0A226M8L1	A0A226N4E1	Aldo_ket_red domain-containing protein.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.588
ASZ78_001493	ASZ78_015722	A0A226M8L1	A0A226NPL3	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.868
ASZ78_001895	ASZ78_001493	A0A226MM97	A0A226M8L1	BH4_AAA_HYDROXYL_2 domain-containing protein.	Aldo_ket_red domain-containing protein.	0.866
ASZ78_001895	ASZ78_001998	A0A226MM97	A0A226MXQ6	BH4_AAA_HYDROXYL_2 domain-containing protein.	Uncharacterized protein.	0.973
ASZ78_001895	ASZ78_002451	A0A226MM97	A0A226MTC5	BH4_AAA_HYDROXYL_2 domain-containing protein.	Uncharacterized protein.	0.951
ASZ78_001895	ASZ78_003112	A0A226MM97	A0A226N655	BH4_AAA_HYDROXYL_2 domain-containing protein.	Uncharacterized protein.	0.939
ASZ78_001895	ASZ78_004153	A0A226MM97	A0A226N8L7	BH4_AAA_HYDROXYL_2 domain-containing protein.	Uncharacterized protein.	0.973
ASZ78_001895	ASZ78_004216	A0A226MM97	A0A226MVL9	BH4_AAA_HYDROXYL_2 domain-containing protein.	Uncharacterized protein.	0.948
ASZ78_001895	ASZ78_007627	A0A226MM97	A0A226M9U1	BH4_AAA_HYDROXYL_2 domain-containing protein.	Aldo_ket_red domain-containing protein.	0.866