(35 nodes) Terpenoid backbone biosynthesis network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_013469	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (793 aa)
	ASZ78_009924	RUN domain-containing protein. (1153 aa)
	ASZ78_016011	Peptidase_M48 domain-containing protein. (310 aa)
	ASZ78_008347	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (362 aa)
	ASZ78_004240	3-hydroxy-3-methylglutaryl coenzyme A reductase. (892 aa)
	ASZ78_017050	Nudix hydrolase domain-containing protein. (177 aa)
	ASZ78_010718	Uncharacterized protein. (761 aa)
	ASZ78_011434	Uncharacterized protein. (112 aa)
	ASZ78_008242	Uncharacterized protein. (358 aa)
	ASZ78_014927	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (351 aa)
	ASZ78_014932	RUN domain-containing protein. (561 aa)
	ASZ78_014930	Uncharacterized protein. (111 aa)
	ASZ78_014929	SH3 domain-containing protein. (128 aa)
	ASZ78_015383	Uncharacterized protein. (193 aa)
	ASZ78_013198	Prenylcys_lyase domain-containing protein. (493 aa)
	ASZ78_002656	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (281 aa)
	ASZ78_015630	Alkyl transferase; Belongs to the UPP synthase family. (261 aa)
	ASZ78_011148	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (539 aa)
	ASZ78_013153	Uncharacterized protein. (383 aa)
	ASZ78_004928	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (531 aa)
	ASZ78_000074	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (426 aa)
	ASZ78_007535	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	ASZ78_010178	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (412 aa)
	ASZ78_011827	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (888 aa)
	ASZ78_000156	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (368 aa)
	ASZ78_005008	Protein-S-isoprenylcysteine O-methyltransferase. (298 aa)
	ASZ78_011063	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (465 aa)
	ASZ78_000792	Uncharacterized protein. (1558 aa)
	ASZ78_010421	TPR_REGION domain-containing protein. (583 aa)
	ASZ78_013999	Uncharacterized protein. (291 aa)
	ASZ78_013996	Uncharacterized protein. (177 aa)
	ASZ78_006182	Prenylcys_lyase domain-containing protein. (500 aa)
	ASZ78_015349	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (409 aa)
	ASZ78_015406	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	ASZ78_015404	Uncharacterized protein. (178 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000074	ASZ78_000156	A0A226MNV5	A0A226MRB1	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.498
ASZ78_000074	ASZ78_000792	A0A226MNV5	A0A226MZ11	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.740
ASZ78_000074	ASZ78_002656	A0A226MNV5	A0A226MJT0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.954
ASZ78_000074	ASZ78_004240	A0A226MNV5	A0A226NFG1	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.641
ASZ78_000074	ASZ78_008242	A0A226MNV5	A0A226MDP4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.938
ASZ78_000074	ASZ78_008347	A0A226MNV5	A0A226NBT0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.931
ASZ78_000074	ASZ78_009924	A0A226MNV5	A0A226N9I6	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	RUN domain-containing protein.	0.730
ASZ78_000074	ASZ78_010178	A0A226MNV5	A0A226MQ78	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.956
ASZ78_000074	ASZ78_010718	A0A226MNV5	A0A226NIC2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.740
ASZ78_000074	ASZ78_011063	A0A226MNV5	A0A226MY22	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.461
ASZ78_000074	ASZ78_011148	A0A226MNV5	A0A226MKB4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.496
ASZ78_000074	ASZ78_013153	A0A226MNV5	A0A226MLD4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.485
ASZ78_000074	ASZ78_013996	A0A226MNV5	A0A226N334	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.933
ASZ78_000074	ASZ78_013999	A0A226MNV5	A0A226N309	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.706
ASZ78_000074	ASZ78_014927	A0A226MNV5	A0A226MEF6	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.942
ASZ78_000074	ASZ78_014929	A0A226MNV5	A0A226MF99	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	SH3 domain-containing protein.	0.730
ASZ78_000074	ASZ78_014930	A0A226MNV5	A0A226MEM4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.936
ASZ78_000074	ASZ78_014932	A0A226MNV5	A0A226MEH8	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	RUN domain-containing protein.	0.730
ASZ78_000074	ASZ78_015349	A0A226MNV5	A0A226N3R9	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.425
ASZ78_000074	ASZ78_015404	A0A226MNV5	A0A226N6B4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.706