(78 nodes) PPAR signaling pathway network (Callipepla squamata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASZ78_009455	Uncharacterized protein. (264 aa)
	ASZ78_009456	Uncharacterized protein. (375 aa)
	ASZ78_009452	Uncharacterized protein. (1252 aa)
	ASZ78_015670	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (685 aa)
	ASZ78_006704	AMP-binding domain-containing protein. (652 aa)
	ASZ78_004584	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	ASZ78_004583	Uncharacterized protein. (75 aa)
	ASZ78_006312	ANK_REP_REGION domain-containing protein. (1025 aa)
	ASZ78_006314	Perilipin; Belongs to the perilipin family. (434 aa)
	ASZ78_006313	Perilipin; Belongs to the perilipin family. (429 aa)
	ASZ78_004638	Uncharacterized protein. (1908 aa)
	ASZ78_007206	Uncharacterized protein. (523 aa)
	ASZ78_011973	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (376 aa)
	ASZ78_008118	Fibrinogen C-terminal domain-containing protein. (482 aa)
	ASZ78_012621	Uncharacterized protein. (859 aa)
	ASZ78_012624	Cytochrome b5 heme-binding domain-containing protein. (444 aa)
	ASZ78_011854	Uncharacterized protein. (622 aa)
	ASZ78_016888	FABP domain-containing protein. (148 aa)
	ASZ78_012192	Perilipin; Belongs to the perilipin family. (431 aa)
	ASZ78_003627	C1q domain-containing protein. (270 aa)
	ASZ78_010604	Uncharacterized protein. (703 aa)
	ASZ78_013439	Uncharacterized protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (266 aa)
	ASZ78_012428	ACB domain-containing protein. (91 aa)
	ASZ78_000855	FABP domain-containing protein. (134 aa)
	ASZ78_000156	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (368 aa)
	ASZ78_009124	Uncharacterized protein. (510 aa)
	ASZ78_010560	Uncharacterized protein. (542 aa)
	ASZ78_000516	AMP-binding domain-containing protein. (723 aa)
	ASZ78_008886	AMP-binding domain-containing protein. (725 aa)
	ASZ78_011765	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (283 aa)
	ASZ78_005788	Uncharacterized protein. (468 aa)
	ASZ78_013122	Uncharacterized protein. (552 aa)
	ASZ78_003843	AMP-binding domain-containing protein. (557 aa)
	ASZ78_003208	Uncharacterized protein. (77 aa)
	ASZ78_003206	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (103 aa)
	ASZ78_007140	Uncharacterized protein. (100 aa)
	ASZ78_007135	NR LBD domain-containing protein. (175 aa)
	ASZ78_007131	Uncharacterized protein. (226 aa)
	ASZ78_011148	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (539 aa)
	ASZ78_001063	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (294 aa)
	ASZ78_002383	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (340 aa)
	ASZ78_002468	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (477 aa)
	ASZ78_013843	Uncharacterized protein. (452 aa)
	ASZ78_002735	Malic domain-containing protein. (109 aa)
	ASZ78_012207	Uncharacterized protein. (409 aa)
	ASZ78_011324	Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
	ASZ78_009523	Uncharacterized protein. (474 aa)
	ASZ78_002269	Protein kinase domain-containing protein. (467 aa)
	ASZ78_009622	AMP-binding domain-containing protein. (666 aa)
	ASZ78_000398	Uncharacterized protein. (443 aa)
	ASZ78_006615	Uncharacterized protein. (504 aa)
	ASZ78_015208	ACB domain-containing protein. (67 aa)
	ASZ78_016739	AMP-binding domain-containing protein. (688 aa)
	ASZ78_005704	Uncharacterized protein; Belongs to the cytochrome P450 family. (603 aa)
	ASZ78_012387	Uncharacterized protein. (508 aa)
	ASZ78_000339	AMP-binding domain-containing protein. (199 aa)
	ASZ78_002931	Uncharacterized protein. (456 aa)
	ASZ78_002933	Acyl-CoA_dh_1 domain-containing protein. (113 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (183 aa)
	ASZ78_011032	Nuclear receptor domain-containing protein. (59 aa)
	ASZ78_003992	Uncharacterized protein. (98 aa)
	ASZ78_011831	Nuclear receptor domain-containing protein. (68 aa)
	ASZ78_009833	Uncharacterized protein. (373 aa)
	ASZ78_000645	Uncharacterized protein. (521 aa)
	ASZ78_010988	AMP-binding domain-containing protein. (675 aa)
	ASZ78_016073	Malic_M domain-containing protein. (143 aa)
	ASZ78_014651	Uncharacterized protein. (601 aa)
	ASZ78_001835	Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
	PPARG-2	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (414 aa)
	ASZ78_001599	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (738 aa)
	ASZ78_014990	Uncharacterized protein. (406 aa)
	ASZ78_016046	Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (587 aa)
	ASZ78_016047	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (490 aa)
	ASZ78_001054	Uncharacterized protein; Belongs to the FGGY kinase family. (539 aa)
	ASZ78_016217	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
	ASZ78_013275	Perilipin; Belongs to the perilipin family. (446 aa)
	ASZ78_002577	Uncharacterized protein; Belongs to the CD36 family. (326 aa)
	ASZ78_001321	AMP-binding domain-containing protein. (551 aa)

Your Current Organism:

Callipepla squamata

NCBI taxonomy Id: 9009
Other names: C. squamata, scaled quail

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASZ78_000156	ASZ78_001599	A0A226MRB1	A0A226NCP2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.939
ASZ78_000156	ASZ78_001835	A0A226MRB1	A0A226NDC8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.570
ASZ78_000156	ASZ78_005704	A0A226MRB1	A0A226NHP0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.617
ASZ78_000156	ASZ78_005788	A0A226MRB1	A0A226MNU8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.568
ASZ78_000156	ASZ78_010560	A0A226MRB1	A0A226MQS4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.422
ASZ78_000156	ASZ78_010988	A0A226MRB1	A0A226NET7	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	AMP-binding domain-containing protein.	0.411
ASZ78_000156	ASZ78_011148	A0A226MRB1	A0A226MKB4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.916
ASZ78_000156	ASZ78_011973	A0A226MRB1	A0A226N1E4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family.	0.412
ASZ78_000156	ASZ78_012621	A0A226MRB1	A0A226MX63	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein.	0.551
ASZ78_000156	ASZ78_016047	A0A226MRB1	A0A226NAH0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.930
ASZ78_000156	ASZ78_016217	A0A226MRB1	A0A226N8H1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.989
ASZ78_000156	ASZ78_016739	A0A226MRB1	A0A226NIZ6	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	AMP-binding domain-containing protein.	0.431
ASZ78_000339	ASZ78_000645	A0A226MCJ2	A0A226NFP9	AMP-binding domain-containing protein.	Uncharacterized protein.	0.550
ASZ78_000339	ASZ78_001321	A0A226MCJ2	A0A226N5N5	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.896
ASZ78_000339	ASZ78_002931	A0A226MCJ2	A0A226MBZ7	AMP-binding domain-containing protein.	Uncharacterized protein.	0.556
ASZ78_000339	ASZ78_003992	A0A226MCJ2	A0A226M8J1	AMP-binding domain-containing protein.	Uncharacterized protein.	0.721
ASZ78_000339	ASZ78_009622	A0A226MCJ2	A0A226NMV2	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.897
ASZ78_000339	ASZ78_009833	A0A226MCJ2	A0A226M728	AMP-binding domain-containing protein.	Uncharacterized protein.	0.417
ASZ78_000339	ASZ78_011324	A0A226MCJ2	A0A226NP36	AMP-binding domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.665
ASZ78_000339	ASZ78_012387	A0A226MCJ2	A0A226MDI6	AMP-binding domain-containing protein.	Uncharacterized protein.	0.713