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| | HBEGF | Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa) |
| | FGFR3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (806 aa) |
| | CD34 | CD34 molecule. (385 aa) |
| | NRG4 | EGF-like domain-containing protein. (113 aa) |
| | PTRF | Leucine zipper protein. (361 aa) |
| | SRC | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. (593 aa) |
| | IRS1 | Insulin receptor substrate 1. (1178 aa) |
| | FLT4 | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1378 aa) |
| | SH3GL3 | Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Implicated in endocytosis of yolk proteins during oogenesis. (353 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa) |
| | CBL | Uncharacterized protein. (903 aa) |
| | SYP | MARVEL domain-containing protein. (338 aa) |
| | FGF4 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa) |
| | VEGFRKDRL | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1316 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa) |
| | GRB2 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa) |
| | IRS4 | Insulin receptor substrate 4. (1164 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa) |
| | PDGFC | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity). (345 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1140 aa) |
| | FRS2 | IRS-type PTB domain-containing protein. (508 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (586 aa) |
| | EPGN | Epigen; Promotes the growth of epithelial cells. (151 aa) |
| | EREG | EGF-like domain-containing protein. (153 aa) |
| | AREG | Amphiregulin. (210 aa) |
| | KITLG | Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa) |
| | IGFBP2 | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (311 aa) |
| | PDGFB | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1330 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa) |
| | NTRK1 | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1333 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1348 aa) |
| | CBLB | Cbl proto-oncogene B. (1025 aa) |
| | NRG1 | Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity). (685 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (803 aa) |
| | PXDN | Peroxidasin. (1611 aa) |
| | SH3KBP1 | Uncharacterized protein. (739 aa) |
| | FGF14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa) |
| | SPRY2 | Protein sprouty homolog 2; May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 through participation in a regulatory negative feedback loop. (313 aa) |
| | KL | Klotho. (999 aa) |
| | FLT1 | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] (1327 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. (506 aa) |
| | GRAPL | Uncharacterized protein. (217 aa) |
| | IGFBP5 | Insulin like growth factor binding protein 5. (269 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1276 aa) |
| | TGFA | EGF-like domain-containing protein. (156 aa) |
| | THY1 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa) |
| | BTC | Betacellulin. (171 aa) |
| | THPO | Thrombopoietin. (177 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | FGF23 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa) |
| | FGF3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | CAV1 | Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa) |
| | PDGFRB | Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1073 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. (773 aa) |
| | ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1200 aa) |
| | EGF | Uncharacterized protein. (1283 aa) |
| | PAPPA2 | Pappalysin 2. (1623 aa) |
| | FGFR2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (824 aa) |
| | SHC1 | Uncharacterized protein. (626 aa) |
| | CTGFL | Uncharacterized protein. (380 aa) |
| | NGFR | Tumor necrosis factor receptor superfamily member 16; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillatio [...] (416 aa) |
| | FGFR1 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] (819 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa) |
| | GRB10 | Uncharacterized protein. (596 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1324 aa) |
| | IGF2 | Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa) |
| | IGF2R | Fibronectin type-II domain-containing protein. (2561 aa) |
| | GAB1 | GRB2 associated binding protein 1. (748 aa) |
| | NTRK3 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells. Belongs to the [...] (852 aa) |
| | PXDNL | Uncharacterized protein. (1406 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa) |
| | ANGPT1 | Fibrinogen C-terminal domain-containing protein. (498 aa) |
| | FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | ERBB3 | Protein kinase domain-containing protein. (1319 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa) |
| | SPRY1 | Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family. (321 aa) |
| | EEA1 | Early endosome antigen 1. (1450 aa) |
| | LAMP1 | Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa) |
| | EGFR | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa) |
| | MCAM | Uncharacterized protein. (626 aa) |
| | SYN3 | Synapsin III. (582 aa) |
| | FLT3 | Fms related tyrosine kinase 3. (877 aa) |
| | MET | Uncharacterized protein. (1382 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | ANXA5 | Annexin A5; Collagen-binding protein. (321 aa) |
| | SPRY4 | Sprouty RTK signaling antagonist 4. (430 aa) |
| | IGFBP3 | Uncharacterized protein. (337 aa) |
| | IGFBP1 | Uncharacterized protein. (269 aa) |
| | KLB | Klotho beta. (992 aa) |
| | VEGFD | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (378 aa) |
| | PAG1 | Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (403 aa) |
| | ETV4 | ETS variant 4. (530 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1363 aa) |
| | NRG2 | Neuregulin 2. (720 aa) |
| | FGFRL1 | Fibroblast growth factor receptor-like 1; Has a negative effect on cell proliferation. (487 aa) |
| | CSK | Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs). Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma mem [...] (450 aa) |
| | ANGPT4 | Angiopoietin 4. (493 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | PDGFA | Platelet-derived growth factor A chain long form; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | LOC419429 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) |
| | CAV2 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (161 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] (1106 aa) |
| | ANGPT2 | Angiopoietin-2A. (493 aa) |
| | FGF10 | Uncharacterized protein. (261 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (247 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). (674 aa) |
| | SORT1 | Sortilin. (954 aa) |
| | PDGFD | Uncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (389 aa) |
| | MATK | Tyrosine-protein kinase. (479 aa) |
| | HYAL3 | Hyaluronidase. (584 aa) |
| | LAMP2 | Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (By similarity). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express [...] (444 aa) |
| | NTRK2 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa) |
| | SHC2 | Uncharacterized protein. (619 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa) |
| | ENSGALP00000070006 | Synaptophysin. (351 aa) |
| | PECAM1 | Platelet and endothelial cell adhesion molecule 1. (712 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons. (270 aa) |
| | FGF1 | Endothelial cell growth factor alpha; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with [...] (155 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa) |
| | TEK | TEK receptor tyrosine kinase. (1128 aa) |
| | MAP2 | Microtubule-associated protein. (1955 aa) |
| | GAB2 | GRB2 associated binding protein 2. (681 aa) |
| | FLOT1 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (876 aa) |
| | FGF11 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. (284 aa) |
| | CD63 | Tetraspanin. (227 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1405 aa) |
