STRINGSTRING
HBEGF HBEGF NRG4 NRG4 EPGN EPGN EREG EREG AREG AREG NRG1 NRG1 ERBB4 ERBB4 TGFA TGFA BTC BTC ERBB2 ERBB2 EGF EGF SHC1 SHC1 ERBB3 ERBB3 EGFR EGFR NRG2 NRG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBEGFProheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)
NRG4EGF-like domain-containing protein. (113 aa)
EPGNEpigen; Promotes the growth of epithelial cells. (151 aa)
EREGEGF-like domain-containing protein. (153 aa)
AREGAmphiregulin. (210 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity). (685 aa)
ERBB4Receptor protein-tyrosine kinase. (1276 aa)
TGFAEGF-like domain-containing protein. (156 aa)
BTCBetacellulin. (171 aa)
ERBB2Receptor protein-tyrosine kinase. (1200 aa)
EGFUncharacterized protein. (1283 aa)
SHC1Uncharacterized protein. (626 aa)
ERBB3Protein kinase domain-containing protein. (1319 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
NRG2Neuregulin 2. (720 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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