(7 nodes) EGFR interacts with phospholipase C-gamma network (Gallus gallus)

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Your Input:
	HBEGF	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)
	EPGN	Epigen; Promotes the growth of epithelial cells. (151 aa)
	EREG	EGF-like domain-containing protein. (153 aa)
	AREG	Amphiregulin. (210 aa)
	BTC	Betacellulin. (171 aa)
	EGF	Uncharacterized protein. (1283 aa)
	EGFR	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREG	BTC	ENSGALP00000017644	ENSGALP00000041051	Amphiregulin.	Betacellulin.	0.956
AREG	EGF	ENSGALP00000017644	ENSGALP00000044972	Amphiregulin.	Uncharacterized protein.	0.929
AREG	EGFR	ENSGALP00000017644	ENSGALP00000053328	Amphiregulin.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.987
AREG	EPGN	ENSGALP00000017644	ENSGALP00000017636	Amphiregulin.	Epigen; Promotes the growth of epithelial cells.	0.935
AREG	EREG	ENSGALP00000017644	ENSGALP00000017642	Amphiregulin.	EGF-like domain-containing protein.	0.989
AREG	HBEGF	ENSGALP00000017644	ENSGALP00000001399	Amphiregulin.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.615
BTC	AREG	ENSGALP00000041051	ENSGALP00000017644	Betacellulin.	Amphiregulin.	0.956
BTC	EGF	ENSGALP00000041051	ENSGALP00000044972	Betacellulin.	Uncharacterized protein.	0.856
BTC	EGFR	ENSGALP00000041051	ENSGALP00000053328	Betacellulin.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.962
BTC	EPGN	ENSGALP00000041051	ENSGALP00000017636	Betacellulin.	Epigen; Promotes the growth of epithelial cells.	0.933
BTC	EREG	ENSGALP00000041051	ENSGALP00000017642	Betacellulin.	EGF-like domain-containing protein.	0.975
BTC	HBEGF	ENSGALP00000041051	ENSGALP00000001399	Betacellulin.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.922
EGF	AREG	ENSGALP00000044972	ENSGALP00000017644	Uncharacterized protein.	Amphiregulin.	0.929
EGF	BTC	ENSGALP00000044972	ENSGALP00000041051	Uncharacterized protein.	Betacellulin.	0.856
EGF	EGFR	ENSGALP00000044972	ENSGALP00000053328	Uncharacterized protein.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.999
EGF	EPGN	ENSGALP00000044972	ENSGALP00000017636	Uncharacterized protein.	Epigen; Promotes the growth of epithelial cells.	0.727
EGF	EREG	ENSGALP00000044972	ENSGALP00000017642	Uncharacterized protein.	EGF-like domain-containing protein.	0.881
EGF	HBEGF	ENSGALP00000044972	ENSGALP00000001399	Uncharacterized protein.	Proheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...]	0.936
EGFR	AREG	ENSGALP00000053328	ENSGALP00000017644	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	Amphiregulin.	0.987
EGFR	BTC	ENSGALP00000053328	ENSGALP00000041051	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	Betacellulin.	0.962