(7 nodes) ERBB2 Regulates Cell Motility, and Neuregulin network (Gallus gallus)

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Your Input:
	NRG4	EGF-like domain-containing protein. (113 aa)
	NRG1	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity). (685 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1276 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1200 aa)
	SHC1	Uncharacterized protein. (626 aa)
	ERBB3	Protein kinase domain-containing protein. (1319 aa)
	NRG2	Neuregulin 2. (720 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERBB2	ERBB3	ENSGALP00000044764	ENSGALP00000051173	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.987
ERBB2	ERBB4	ENSGALP00000044764	ENSGALP00000039169	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.962
ERBB2	NRG1	ENSGALP00000044764	ENSGALP00000024830	Receptor protein-tyrosine kinase.	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).	0.970
ERBB2	NRG2	ENSGALP00000044764	ENSGALP00000057015	Receptor protein-tyrosine kinase.	Neuregulin 2.	0.804
ERBB2	NRG4	ENSGALP00000044764	ENSGALP00000004655	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.663
ERBB2	SHC1	ENSGALP00000044764	ENSGALP00000045508	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.983
ERBB3	ERBB2	ENSGALP00000051173	ENSGALP00000044764	Protein kinase domain-containing protein.	Receptor protein-tyrosine kinase.	0.987
ERBB3	ERBB4	ENSGALP00000051173	ENSGALP00000039169	Protein kinase domain-containing protein.	Receptor protein-tyrosine kinase.	0.739
ERBB3	NRG1	ENSGALP00000051173	ENSGALP00000024830	Protein kinase domain-containing protein.	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).	0.998
ERBB3	NRG2	ENSGALP00000051173	ENSGALP00000057015	Protein kinase domain-containing protein.	Neuregulin 2.	0.983
ERBB3	NRG4	ENSGALP00000051173	ENSGALP00000004655	Protein kinase domain-containing protein.	EGF-like domain-containing protein.	0.649
ERBB3	SHC1	ENSGALP00000051173	ENSGALP00000045508	Protein kinase domain-containing protein.	Uncharacterized protein.	0.981
ERBB4	ERBB2	ENSGALP00000039169	ENSGALP00000044764	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.962
ERBB4	ERBB3	ENSGALP00000039169	ENSGALP00000051173	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.739
ERBB4	NRG1	ENSGALP00000039169	ENSGALP00000024830	Receptor protein-tyrosine kinase.	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).	0.997
ERBB4	NRG2	ENSGALP00000039169	ENSGALP00000057015	Receptor protein-tyrosine kinase.	Neuregulin 2.	0.986
ERBB4	NRG4	ENSGALP00000039169	ENSGALP00000004655	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.983
ERBB4	SHC1	ENSGALP00000039169	ENSGALP00000045508	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.978
NRG1	ERBB2	ENSGALP00000024830	ENSGALP00000044764	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).	Receptor protein-tyrosine kinase.	0.970
NRG1	ERBB3	ENSGALP00000024830	ENSGALP00000051173	Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).	Protein kinase domain-containing protein.	0.998