STRINGSTRING
ITGB3 ITGB3 LAMB3 LAMB3 E1C7K2_CHICK E1C7K2_CHICK COMP COMP FN1 FN1 MMP2 MMP2 VTN VTN SPARC SPARC ASPN ASPN FBN1 FBN1 VCL VCL FBLN2 FBLN2 VCAM1 VCAM1 PTH2R PTH2R MMP11 MMP11 ACAN ACAN TNMD TNMD ITGB2 ITGB2 LAMB1 LAMB1 ITGA11 ITGA11 THBS1 THBS1 COL1A2 COL1A2 FBLN5 FBLN5 SPP1 SPP1 ITGB6 ITGB6 LUM LUM MGP MGP FBLN1 FBLN1 THBS4 THBS4 PELO PELO ITGA2 ITGA2 COL10A1 COL10A1 LAMA4 LAMA4 VCAN VCAN ADAMTS5 ADAMTS5 SDC1 SDC1 MMP13 MMP13 MMP10 MMP10 MMP1 MMP1 MMP7 MMP7 CD47 CD47 CHAD CHAD ADAM17 ADAM17 SV2C SV2C LAMA1 LAMA1 IBSP IBSP SOX9 SOX9 LAMC1 LAMC1 OMD OMD TNFSF11 TNFSF11 TIMP3 TIMP3 MMP3 MMP3 TIMP2 TIMP2 OGN OGN COL6A2 COL6A2 LAMA3 LAMA3 FMOD FMOD PTH PTH LOC428277 LOC428277 FLNB FLNB CTSK CTSK ITGAV ITGAV LAMB2 LAMB2 ITGB5 ITGB5 MMP16 MMP16 MMP24 MMP24 COL4A1 COL4A1 RUNX2 RUNX2 ITGA3 ITGA3 COL3A1 COL3A1 HSPG2 HSPG2 SCX SCX DAG1 DAG1 ITGA7 ITGA7 SOST SOST DMP1 DMP1 NID1 NID1 COL2A1 COL2A1 ITGA4 ITGA4 ITGB1 ITGB1 TNFRSF11B TNFRSF11B ITGA9 ITGA9 MMP15 MMP15 BGLAP BGLAP ITGA6 ITGA6 TLN1 TLN1 OPTC OPTC CD44 CD44 SV2B SV2B COL6A1 COL6A1 COL1A1 COL1A1 BCAN BCAN DCN DCN MKX MKX TNR TNR TNFRSF11A TNFRSF11A TLN2 TLN2 ENSGALP00000064934 ENSGALP00000064934 SP7 SP7 DEPDC1 DEPDC1 NID2 NID2 COL4A2 COL4A2 MADCAM1 MADCAM1 ITGA8 ITGA8 LAMA2 LAMA2 POSTN POSTN ENSGALP00000066134 ENSGALP00000066134 ITGA2B ITGA2B LOXL1 LOXL1 LAMB4 LAMB4 FLNA FLNA ENSGALP00000067567 ENSGALP00000067567 SH3BP2 SH3BP2 DCSTAMP DCSTAMP ENSGALP00000068604 ENSGALP00000068604 MMP9 MMP9 LTBP2 LTBP2 CD36 CD36 PTHLH PTHLH ENSGALP00000069232 ENSGALP00000069232 ELN ELN LTBP1 LTBP1 ITGAD ITGAD ENSGALP00000069758 ENSGALP00000069758 CTHRC1 CTHRC1 TNN TNN SDC4 SDC4 PTK2 PTK2 COL6A3 COL6A3 LAMC3 LAMC3 PHEX PHEX MFAP5 MFAP5 SORBS1 SORBS1 TIMP4 TIMP4 HAPLN1 HAPLN1 THBS2 THBS2 ENSGALP00000073351 ENSGALP00000073351 SV2A SV2A LAMA5 LAMA5 ITGB7 ITGB7 ENSGALP00000074243 ENSGALP00000074243
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
LAMB3Laminin subunit beta 3. (1168 aa)
E1C7K2_CHICKUncharacterized protein. (134 aa)
COMPUncharacterized protein. (777 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
MMP272 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa)
VTNSMB domain-containing protein. (453 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
ASPNAsporin. (371 aa)
FBN1Fibrillin 1. (2861 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
FBLN2Fibulin 2. (1196 aa)
VCAM1Uncharacterized protein. (541 aa)
PTH2RParathyroid hormone-related protein type-1 receptor; Belongs to the G-protein coupled receptor 2 family. (538 aa)
MMP11Matrix metallopeptidase 11. (456 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa)
TNMDBRICHOS domain-containing protein. (319 aa)
ITGB2Integrin beta. (773 aa)
LAMB1Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1785 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa)
THBS1Uncharacterized protein. (1175 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
FBLN5Uncharacterized protein. (444 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
LUMLumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation; Belongs to the osteocalcin/matrix Gla protein family. (103 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes; Belongs to the fibulin family. (704 aa)
THBS4Uncharacterized protein. (953 aa)
PELOIntegrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). (1175 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa)
COL10A1Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. (674 aa)
LAMA4Laminin subunit alpha 4. (1827 aa)
VCANVersican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (877 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (308 aa)
MMP13ZnMc domain-containing protein. (530 aa)
MMP10ZnMc domain-containing protein. (496 aa)
MMP1Matrix metallopeptidase 1. (466 aa)
MMP7ZnMc domain-containing protein. (267 aa)
CD47CD47 glycoprotein isoform A. (317 aa)
CHADUncharacterized protein. (361 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
SV2CSynaptic vesicle glycoprotein 2C. (727 aa)
LAMA1Uncharacterized protein. (3091 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). (200 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
LAMC1Laminin subunit gamma 1. (1603 aa)
OMDOsteomodulin. (413 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. (212 aa)
MMP3ZnMc domain-containing protein. (477 aa)
TIMP2Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. (220 aa)
OGNMimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (294 aa)
COL6A2Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. (1022 aa)
LAMA3Laminin subunit alpha 3. (3448 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (380 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
LOC428277Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (547 aa)
FLNBUncharacterized protein. (2652 aa)
CTSKCathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). (334 aa)
ITGAVIntegrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa)
LAMB2Uncharacterized protein. (1802 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
MMP16ZnMc domain-containing protein. (609 aa)
MMP24Matrix metallopeptidase 24. (596 aa)
COL4A1Collagen IV NC1 domain-containing protein. (1669 aa)
RUNX2Runt-related transcription factor. (472 aa)
ITGA3Uncharacterized protein; Belongs to the integrin alpha chain family. (1108 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
HSPG2Heparan sulfate proteoglycan 2. (3948 aa)
SCXBasic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. (187 aa)
DAG1Peptidase S72 domain-containing protein. (896 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1180 aa)
SOSTSclerostin. (213 aa)
DMP1Uncharacterized protein. (429 aa)
NID1Nidogen 1. (1153 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
ITGA9Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa)
MMP15Matrix metallopeptidase 15. (647 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
ITGA6Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. (1072 aa)
TLN1Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. (2558 aa)
OPTCLRRNT domain-containing protein. (338 aa)
CD44Link domain-containing protein. (696 aa)
SV2BSynaptic vesicle glycoprotein 2B. (705 aa)
COL6A1Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. (1019 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
BCANBrevican. (968 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
MKXMohawk homeobox. (350 aa)
TNRTenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth. (1353 aa)
TNFRSF11ATNF receptor superfamily member 11a. (656 aa)
TLN2Talin 2. (2523 aa)
ENSGALP00000064934Uncharacterized protein. (2030 aa)
SP7Sp7 transcription factor. (381 aa)
DEPDC1DEP domain-containing protein. (812 aa)
NID2Uncharacterized protein. (1170 aa)
COL4A2Collagen IV NC1 domain-containing protein. (1847 aa)
MADCAM1Uncharacterized protein. (456 aa)
ITGA8Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa)
LAMA2Uncharacterized protein. (598 aa)
POSTNUncharacterized protein. (857 aa)
ENSGALP00000066134Laminin N-terminal domain-containing protein. (533 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (866 aa)
LOXL1Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin; Belongs to the lysyl oxidase family. (511 aa)
LAMB4Uncharacterized protein. (1831 aa)
FLNAUncharacterized protein. (492 aa)
ENSGALP00000067567Laminin IV type B domain-containing protein. (312 aa)
SH3BP2Uncharacterized protein. (577 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (472 aa)
ENSGALP00000068604Uncharacterized protein. (186 aa)
MMP9Uncharacterized protein. (713 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1851 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
PTHLHParathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
ENSGALP00000069232Uncharacterized protein. (626 aa)
ELNElastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. (811 aa)
LTBP1Uncharacterized protein. (1656 aa)
ITGADVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1068 aa)
ENSGALP00000069758Uncharacterized protein. (176 aa)
CTHRC1Collagen triple helix repeat containing 1. (314 aa)
TNNTenascin N. (1125 aa)
SDC4Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. (197 aa)
PTK2Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] (1102 aa)
COL6A3Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. (3215 aa)
LAMC3Uncharacterized protein. (332 aa)
PHEXUncharacterized protein. (747 aa)
MFAP5Microfibril associated protein 5. (154 aa)
SORBS1Sorbin and SH3 domain containing 1. (950 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (254 aa)
HAPLN1Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (355 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
ENSGALP00000073351Integrin_alpha2 domain-containing protein. (465 aa)
SV2ASynaptic vesicle glycoprotein 2A. (751 aa)
LAMA5Laminin subunit alpha 5. (3725 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (538 aa)
ENSGALP00000074243Uncharacterized protein. (1200 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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