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| ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (781 aa) | ||||
| LAMB3 | Laminin subunit beta 3. (1168 aa) | ||||
| E1C7K2_CHICK | Uncharacterized protein. (134 aa) | ||||
| COMP | Uncharacterized protein. (777 aa) | ||||
| FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa) | ||||
| MMP2 | 72 kDa type IV collagenase; Belongs to the peptidase M10A family. (663 aa) | ||||
| VTN | SMB domain-containing protein. (453 aa) | ||||
| SPARC | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa) | ||||
| ASPN | Asporin. (371 aa) | ||||
| FBN1 | Fibrillin 1. (2861 aa) | ||||
| VCL | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa) | ||||
| FBLN2 | Fibulin 2. (1196 aa) | ||||
| VCAM1 | Uncharacterized protein. (541 aa) | ||||
| PTH2R | Parathyroid hormone-related protein type-1 receptor; Belongs to the G-protein coupled receptor 2 family. (538 aa) | ||||
| MMP11 | Matrix metallopeptidase 11. (456 aa) | ||||
| ACAN | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa) | ||||
| TNMD | BRICHOS domain-containing protein. (319 aa) | ||||
| ITGB2 | Integrin beta. (773 aa) | ||||
| LAMB1 | Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1785 aa) | ||||
| ITGA11 | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1240 aa) | ||||
| THBS1 | Uncharacterized protein. (1175 aa) | ||||
| COL1A2 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa) | ||||
| FBLN5 | Uncharacterized protein. (444 aa) | ||||
| SPP1 | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa) | ||||
| ITGB6 | Integrin beta; Belongs to the integrin beta chain family. (789 aa) | ||||
| LUM | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa) | ||||
| MGP | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation; Belongs to the osteocalcin/matrix Gla protein family. (103 aa) | ||||
| FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes; Belongs to the fibulin family. (704 aa) | ||||
| THBS4 | Uncharacterized protein. (953 aa) | ||||
| PELO | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). (1175 aa) | ||||
| ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa) | ||||
| COL10A1 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. (674 aa) | ||||
| LAMA4 | Laminin subunit alpha 4. (1827 aa) | ||||
| VCAN | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa) | ||||
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif 5. (877 aa) | ||||
| SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (308 aa) | ||||
| MMP13 | ZnMc domain-containing protein. (530 aa) | ||||
| MMP10 | ZnMc domain-containing protein. (496 aa) | ||||
| MMP1 | Matrix metallopeptidase 1. (466 aa) | ||||
| MMP7 | ZnMc domain-containing protein. (267 aa) | ||||
| CD47 | CD47 glycoprotein isoform A. (317 aa) | ||||
| CHAD | Uncharacterized protein. (361 aa) | ||||
| ADAM17 | Tumor necrosis factor alpha converting enzyme. (829 aa) | ||||
| SV2C | Synaptic vesicle glycoprotein 2C. (727 aa) | ||||
| LAMA1 | Uncharacterized protein. (3091 aa) | ||||
| IBSP | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). (200 aa) | ||||
| SOX9 | Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa) | ||||
| LAMC1 | Laminin subunit gamma 1. (1603 aa) | ||||
| OMD | Osteomodulin. (413 aa) | ||||
| TNFSF11 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa) | ||||
| TIMP3 | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. (212 aa) | ||||
| MMP3 | ZnMc domain-containing protein. (477 aa) | ||||
| TIMP2 | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. (220 aa) | ||||
| OGN | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (294 aa) | ||||
| COL6A2 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. (1022 aa) | ||||
| LAMA3 | Laminin subunit alpha 3. (3448 aa) | ||||
| FMOD | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (380 aa) | ||||
| PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa) | ||||
| LOC428277 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (547 aa) | ||||
| FLNB | Uncharacterized protein. (2652 aa) | ||||
| CTSK | Cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). (334 aa) | ||||
| ITGAV | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa) | ||||
| LAMB2 | Uncharacterized protein. (1802 aa) | ||||
| ITGB5 | Integrin beta; Belongs to the integrin beta chain family. (811 aa) | ||||
| MMP16 | ZnMc domain-containing protein. (609 aa) | ||||
| MMP24 | Matrix metallopeptidase 24. (596 aa) | ||||
| COL4A1 | Collagen IV NC1 domain-containing protein. (1669 aa) | ||||
| RUNX2 | Runt-related transcription factor. (472 aa) | ||||
| ITGA3 | Uncharacterized protein; Belongs to the integrin alpha chain family. (1108 aa) | ||||
| COL3A1 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa) | ||||
| HSPG2 | Heparan sulfate proteoglycan 2. (3948 aa) | ||||
| SCX | Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. (187 aa) | ||||
| DAG1 | Peptidase S72 domain-containing protein. (896 aa) | ||||
| ITGA7 | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1180 aa) | ||||
| SOST | Sclerostin. (213 aa) | ||||
| DMP1 | Uncharacterized protein. (429 aa) | ||||
| NID1 | Nidogen 1. (1153 aa) | ||||
| COL2A1 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa) | ||||
| ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa) | ||||
| ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa) | ||||
| TNFRSF11B | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa) | ||||
| ITGA9 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1031 aa) | ||||
| MMP15 | Matrix metallopeptidase 15. (647 aa) | ||||
| BGLAP | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa) | ||||
| ITGA6 | Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. (1072 aa) | ||||
| TLN1 | Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. (2558 aa) | ||||
| OPTC | LRRNT domain-containing protein. (338 aa) | ||||
| CD44 | Link domain-containing protein. (696 aa) | ||||
| SV2B | Synaptic vesicle glycoprotein 2B. (705 aa) | ||||
| COL6A1 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family. (1019 aa) | ||||
| COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa) | ||||
| BCAN | Brevican. (968 aa) | ||||
| DCN | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa) | ||||
| MKX | Mohawk homeobox. (350 aa) | ||||
| TNR | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth. (1353 aa) | ||||
| TNFRSF11A | TNF receptor superfamily member 11a. (656 aa) | ||||
| TLN2 | Talin 2. (2523 aa) | ||||
| ENSGALP00000064934 | Uncharacterized protein. (2030 aa) | ||||
| SP7 | Sp7 transcription factor. (381 aa) | ||||
| DEPDC1 | DEP domain-containing protein. (812 aa) | ||||
| NID2 | Uncharacterized protein. (1170 aa) | ||||
| COL4A2 | Collagen IV NC1 domain-containing protein. (1847 aa) | ||||
| MADCAM1 | Uncharacterized protein. (456 aa) | ||||
| ITGA8 | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa) | ||||
| LAMA2 | Uncharacterized protein. (598 aa) | ||||
| POSTN | Uncharacterized protein. (857 aa) | ||||
| ENSGALP00000066134 | Laminin N-terminal domain-containing protein. (533 aa) | ||||
| ITGA2B | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (866 aa) | ||||
| LOXL1 | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin; Belongs to the lysyl oxidase family. (511 aa) | ||||
| LAMB4 | Uncharacterized protein. (1831 aa) | ||||
| FLNA | Uncharacterized protein. (492 aa) | ||||
| ENSGALP00000067567 | Laminin IV type B domain-containing protein. (312 aa) | ||||
| SH3BP2 | Uncharacterized protein. (577 aa) | ||||
| DCSTAMP | Dendrocyte expressed seven transmembrane protein. (472 aa) | ||||
| ENSGALP00000068604 | Uncharacterized protein. (186 aa) | ||||
| MMP9 | Uncharacterized protein. (713 aa) | ||||
| LTBP2 | Latent transforming growth factor beta binding protein 2. (1851 aa) | ||||
| CD36 | Uncharacterized protein; Belongs to the CD36 family. (471 aa) | ||||
| PTHLH | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa) | ||||
| ENSGALP00000069232 | Uncharacterized protein. (626 aa) | ||||
| ELN | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. (811 aa) | ||||
| LTBP1 | Uncharacterized protein. (1656 aa) | ||||
| ITGAD | VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1068 aa) | ||||
| ENSGALP00000069758 | Uncharacterized protein. (176 aa) | ||||
| CTHRC1 | Collagen triple helix repeat containing 1. (314 aa) | ||||
| TNN | Tenascin N. (1125 aa) | ||||
| SDC4 | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. (197 aa) | ||||
| PTK2 | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous s [...] (1102 aa) | ||||
| COL6A3 | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein. (3215 aa) | ||||
| LAMC3 | Uncharacterized protein. (332 aa) | ||||
| PHEX | Uncharacterized protein. (747 aa) | ||||
| MFAP5 | Microfibril associated protein 5. (154 aa) | ||||
| SORBS1 | Sorbin and SH3 domain containing 1. (950 aa) | ||||
| TIMP4 | TIMP metallopeptidase inhibitor 4. (254 aa) | ||||
| HAPLN1 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (355 aa) | ||||
| THBS2 | Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa) | ||||
| ENSGALP00000073351 | Integrin_alpha2 domain-containing protein. (465 aa) | ||||
| SV2A | Synaptic vesicle glycoprotein 2A. (751 aa) | ||||
| LAMA5 | Laminin subunit alpha 5. (3725 aa) | ||||
| ITGB7 | Integrin beta; Belongs to the integrin beta chain family. (538 aa) | ||||
| ENSGALP00000074243 | Uncharacterized protein. (1200 aa) | ||||