(10 nodes) Mixed, incl. Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan, and Sulfation network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FN1	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). (2526 aa)
	SPARC	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
	ASPN	Asporin. (371 aa)
	FBN1	Fibrillin 1. (2861 aa)
	LUM	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa)
	VCAN	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa)
	COL3A1	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
	DCN	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (357 aa)
	POSTN	Uncharacterized protein. (857 aa)
	ELN	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. (811 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPN	COL3A1	ENSGALP00000007507	ENSGALP00000051057	Asporin.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.942
ASPN	DCN	ENSGALP00000007507	ENSGALP00000062069	Asporin.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.607
ASPN	ELN	ENSGALP00000007507	ENSGALP00000069288	Asporin.	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	0.642
ASPN	FBN1	ENSGALP00000007507	ENSGALP00000007941	Asporin.	Fibrillin 1.	0.608
ASPN	FN1	ENSGALP00000007507	ENSGALP00000005653	Asporin.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	0.718
ASPN	LUM	ENSGALP00000007507	ENSGALP00000018370	Asporin.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.621
ASPN	POSTN	ENSGALP00000007507	ENSGALP00000066072	Asporin.	Uncharacterized protein.	0.775
ASPN	SPARC	ENSGALP00000007507	ENSGALP00000006639	Asporin.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).	0.650
ASPN	VCAN	ENSGALP00000007507	ENSGALP00000025144	Asporin.	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.746
COL3A1	ASPN	ENSGALP00000051057	ENSGALP00000007507	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Asporin.	0.942
COL3A1	DCN	ENSGALP00000051057	ENSGALP00000062069	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.985
COL3A1	ELN	ENSGALP00000051057	ENSGALP00000069288	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.	0.999
COL3A1	FBN1	ENSGALP00000051057	ENSGALP00000007941	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Fibrillin 1.	0.872
COL3A1	FN1	ENSGALP00000051057	ENSGALP00000005653	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).	0.999
COL3A1	LUM	ENSGALP00000051057	ENSGALP00000018370	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.827
COL3A1	POSTN	ENSGALP00000051057	ENSGALP00000066072	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Uncharacterized protein.	0.915
COL3A1	SPARC	ENSGALP00000051057	ENSGALP00000006639	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).	0.973
COL3A1	VCAN	ENSGALP00000051057	ENSGALP00000025144	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.	0.852
DCN	ASPN	ENSGALP00000062069	ENSGALP00000007507	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Asporin.	0.607
DCN	COL3A1	ENSGALP00000062069	ENSGALP00000051057	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.985