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| | LHX2 | LIM homeodomain. (400 aa) |
| | LHX3 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa) |
| | CUX1 | CASP_C domain-containing protein. (678 aa) |
| | SDF4 | 45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family. (356 aa) |
| | FOXI1 | Forkhead box I1. (375 aa) |
| | TLX3 | T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa) |
| | LMX1A | Uncharacterized protein. (380 aa) |
| | LEUTX | Homeobox domain-containing protein. (403 aa) |
| | DLX1 | Homeodomain transcription factor DLX1. (255 aa) |
| | CUX2 | Homeobox protein cut-like. (1386 aa) |
| | FOXN4 | Forkhead box N4. (513 aa) |
| | LHX1 | LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa) |
| | BHLHE23 | BHLH transcription factor neuroAB. (220 aa) |
| | FEZF2 | FEZ family zinc finger 2. (441 aa) |
| | HMX3 | Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (308 aa) |
| | TLX1 | T-cell leukemia homeobox protein 1; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (297 aa) |
| | LHX5 | LIM homeobox protein 5. (402 aa) |
| | NEUROD1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa) |
| | DLX5 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa) |
| | VAX1 | Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa) |
| | DMRT3 | Doublesex and mab-3 related transcription factor 3. (466 aa) |
| | SIM1 | SIM bHLH transcription factor 1. (766 aa) |
| | MYT1L | Myelin transcription factor 1 like. (1190 aa) |
| | SIX4 | SIX homeobox 4. (776 aa) |
| | EBF1 | IPT/TIG domain-containing protein. (604 aa) |
| | SIX6 | Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa) |
| | PTF1A | Pancreas associated transcription factor 1a. (275 aa) |
| | OTP | Orthopedia homeobox. (325 aa) |
| | CALB2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa) |
| | SATB2 | DNA-binding protein SATB. (731 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa) |
| | DMRT2 | Doublesex and mab-3 related transcription factor 2. (597 aa) |
| | SIX2 | Sine oculis-related homeobox 2 homolog. (287 aa) |
| | SALL1 | Uncharacterized protein. (1308 aa) |
| | FOXI3 | Fork-head domain-containing protein. (395 aa) |
| | HINFP | Histone H4 transcription factor. (546 aa) |
| | LHX6 | LIM homeobox 6. (380 aa) |
| | PAX2 | Paired-box containing protein Pax-2. (394 aa) |
| | OTX2 | Homeodomain transcription factor. (289 aa) |
| | ONECUT1 | One cut domain family member. (450 aa) |
| | HOXD11 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (280 aa) |
| | SIX1 | Sine oculis-related homeobox 1 homolog. (282 aa) |
| | POU4F1 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa) |
| | OLIG2 | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa) |
| | ASCL1 | BHLH domain-containing protein. (219 aa) |
| | PVALB | Parvalbumin, muscle; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity); Belongs to the parvalbumin family. (134 aa) |
| | VSX2 | Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa) |
| | TBR1 | T-box brain transcription factor 1. (677 aa) |
| | SOX14 | Transcription factor SOX-14; Acts as a negative regulator of transcription. (240 aa) |
| | NEUROD2 | Neurogenic differentiation factor. (356 aa) |
| | SOX1 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa) |
| | ENSGALP00000050538 | Uncharacterized protein. (107 aa) |
| | PRDM8 | PR/SET domain 8. (336 aa) |
| | POU6F2 | Uncharacterized protein. (166 aa) |
| | EYA1 | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa) |
| | GBX2 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa) |
| | DLX2 | Distal-less homeobox 2. (253 aa) |
| | EMX1 | Empty spiracles homeobox 1. (235 aa) |
| | BHLHE22 | Class E basic helix-loop-helix protein 22; May act as a transcriptional repressor. (309 aa) |
| | GAD1 | Glutamate decarboxylase 67. (590 aa) |
| | BCL11A | Uncharacterized protein. (796 aa) |
| | LMX1B | LIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa) |
| | FGF13 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) |
| | SLC32A1 | Solute carrier family 32 member 1. (521 aa) |
| | FOXG1 | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa) |
| | NKX2-2 | Homeobox domain-containing protein. (272 aa) |
| | NKX2-1 | Homeobox domain-containing protein. (345 aa) |
| | ISL2 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, LIM-3 and ISL-1. (356 aa) |
| | SLC17A6 | MFS domain-containing protein. (585 aa) |
| | VSX1 | Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Belongs to the paired homeobox family. (349 aa) |
| | SLC6A5 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (794 aa) |
| | CALB1 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa) |
| | MNX1 | Homeobox domain-containing protein. (348 aa) |
| | BARHL2 | BarH like homeobox 2. (369 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (884 aa) |
| | NEUROG1 | Neurogenin 1. (179 aa) |
| | SIX3 | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa) |
| | POU4F2 | POU domain protein. (418 aa) |
| | LHX4 | LIM homeobox 4. (533 aa) |
| | DACH1 | Ski_Sno domain-containing protein. (712 aa) |
| | ATOH7 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3. (151 aa) |
| | TAL2 | TAL bHLH transcription factor 2. (117 aa) |
| | EMX2 | Empty spiracles homeobox 2. (336 aa) |
| | NEUROD6 | Neurogenic differentiation factor. (337 aa) |
| | HELT | Helt bHLH transcription factor. (240 aa) |
| | DLX6 | Homeobox domain-containing protein. (283 aa) |
| | PAX6 | Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa) |
| | ZFHX4 | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family. (3595 aa) |
| | LHX9 | LIM/homeobox protein Lhx9; May be involved in gonadal development. (455 aa) |
| | OSR1 | Uncharacterized protein. (260 aa) |
| | ZNF423 | Zinc finger protein 423. (1322 aa) |
